First published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.
Table of Contents
Principles of Positron Emission Tomography. Neurotransmitters and Receptors in the Basal Ganglia. Tracer Studies of Neuro-Receptor Kinetics In Vivo. Dopamine Receptor Studies with Positron Emission Tomography. (Commentary-Different Methods of Measuring Binding to the Effector Ligand Binding Sites of Neurotransmitter Receptors: A Note of Caution.) Parkinson's Disease and Aging: Presynaptic Nigrostriatal Function. Cerebral Energy Metabolism and Blood Flow in Parkinson's Disease. MPTP-Induced Parkinsonism. Positron Emission Tomograph in Progressive Supranuclear Palsy. Olivopontocerebellar Atrophy. Positron Emission Tomography and Huntington's Disease. Clinical Management of Huntington's Disease: The Role of PET and DNA Linkage Studies. Dystonia. Dementia in Movement Disorders. Future Directions for PET in Neurology.
W. R. Wayne Martin