1st Edition

Fundamentals of Asymmetric Synthesis

By G. L. David Krupadanam Copyright 2014
    468 Pages
    by CRC Press

    Asymmetric synthesis is an integral part of synthetic organic chemistry. Some of the reactions in this book were known prior to 1980, while several new ones, particularly catalytic asymmetric reactions, have been discovered in the recent years. The impact of this new class of reactions has been impressively extensive—both on organic and medicinal chemistry. These reactions have been accepted whole-heartedly by synthetic organic chemists in developing shorter routes for complex natural targets as well as in the manufacture of a wide range of drug intermediates.

    Terms, Definitions and Concepts in Asymmetric Synthesis
    Achiral and Chiral Molecules and Their Properties
    Enantioselective and Diastereoselective Synthesis
    Methods for Monitoring Enantioselective and Diastereoselective Synthesis
    Methods for Inducing Asymmetry
    Chiral Substrate Controlled Asymmetric Reactions: Diastereoselection in acyclic systems
    Chiral auxiliary controlled asymmetric reactions—Asymmetric α-alkylations
    Chiral Stoichiometric Reagent Controlled Asymmetric Synthesis: Chiral Boron Reagents
    Chiral Catalyst Mediated Asymmetric Reactions: Enzymes
    Chiral Organometallic Catalysed Asymmetric Reactions: Sharpless Asymmetric Epoxidations, Dihydroxylations and Aminohydroxylations
    Chiral Organometallic Catalysed Asymmetric Reactions
    Organocatalysts in Asymmetric Synthesis—Chiral Additive Mediated Reactions
    Asymmetric Aldol Reaction
    Asymmetric Diels–Alder reactions
    Stereoselective Synthesis and Stereospecific Synthesis


    G. L. David Krupadanam