Fungal Pathogenesis: Principles and Clinical Applications, 1st Edition (Hardback) book cover

Fungal Pathogenesis

Principles and Clinical Applications, 1st Edition

By Richard Calderone

CRC Press

776 pages

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Hardback: 9780824705688
pub: 2001-10-12
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Stresses molecular and biochemical studies of opportunistic and frank fungal pathogens!

This book gives a comprehensive overview of human pathogenic fungi that offers a current and concise survey of virulence factors, host responses and recognition, treatment and diagnosis of infections, invasive enzymes, intracellular survival, morphogenesis, adaptation, and properties of major fungal pathogens that contribute to disease.

Focuses on human fungal infections, including candidiasis, pneumocystosis, aspergillosis, and cryptococcosis.

With over 3700 references to accommodate continuing study, Fungal Pathogenesis

  • covers natural and acquired immunity, vaccine development, and immune reconstitution

  • outlines rapid identification of major mycoses utilizing antigen capture and molecular assays

  • details signaling and phenotypic switching

  • discusses the value of genomics in validation

  • highlights state-of-the-art molecular methodologies to study disease-causing organisms

  • describes available and potential antifungal drug targets and drug development

  • considers predicting the consequences of drug resistance on patient management

  • presents topical observations on strain typing and variation

  • and more!

    Containing research into the virulence, immunity, diagnosis, and therapy of most common fungal infections, Fungal Pathogenesis is an unparalleled reference for microbiologists, virologists, pathologists and phytopathologists, infectious disease specialists, molecular and cell biologists, biochemists, immunologists, medical mycologists, biotechnologists, and geneticists, and an exceptional text for upper-level undergraduate, graduate, and medical school students in these disciplines.

  • Table of Contents

    W. LaJean Chaffin

    Genetic Basis of Pathogenicity in Cryptococcus neoformans

    Brian L. Wickes and K. J. Kwon-Chung

    Secretory Proteins in Fungal Virulence

    Pranab K. Mukherjee and Mahmoud A. Ghannoum

    Histoplasma capsulatum: Diary of an Intracellular Survivor

    Simon L. Newman

    Dimorphism in Human Pathogens

    Jon P. Woods

    Signaling and the Biology of Human Fungal Pathogens

    Jose Antonio Calera and Richard A. Calderone

    Adaptation of Fungi to Alterations in Ambient pH

    Oliver Kurzai, Abdelmalic El Barkani, and Fritz A. Mühlschlegel

    Molecular Biology of Switching in Candida

    David R. Soll

    Pathogenic Properties of Blastomyces dermatitidis

    Bruce S. Klein and Wun-Ling Chang

    Paracoccidioides brasiliensis: Virulence and Host Response

    Gioconda San-Blas and Gustavo Niño-Vega

    Pneumocystis carinii

    Henry Koziel

    Genomics in Fungal Pathogenesis

    Janna L. Beckerman and P. T. Magee


    Cell-Mediated Immunity and Endemic Mycoses

    D. Mitchell Magee and Rebecca A. Cox

    Humoral Immunity and Cryptococcus neoformans

    Arturo Casadevall

    Vaccines, Antibodies, and Passive Immunity in Candidiasis

    Jim E. Cutler, Bruce L. Granger, and Yongmoon Han

    Vaccines for Histoplasmosis

    George S. Deepe, Jr.

    Coccidioidomycosis: Pathogenesis, Immune Response, and Vaccine Development

    Theo N. Kirkland and Garry T. Cole

    Innate Immunity Against Fungal Pathogens

    Luigina Romani

    Immune Reconstitution Against Human Mycoses

    Emmanuel Roilides, Evangelia Farmaki, and Caron A. Lyman

    Mucosal Infection and Immunity in Candidiasis

    Flavia De Bernardis and Maria Boccanera

    Systemic Immunity in Candidiasis

    Luigina Romani and Francesco Bistoni

    Cell Wall of Aspergillus fumigatus: Structure, Biosynthesis, and Role in Host-Fungus Interactions

    Isabelle Mouyna and Jean-Paul Latgé

    Cryptococcus neoformans and Macrophages

    Thomas S. Harrison and Stuart M. Levitz


    Antifungals Currently Used in the Treatment of Invasive Fungal Diseases

    Xiao-jiong Zhao and Richard A. Calderone

    Antifungal Drug Targets: Discovery and Selection

    Ronald L. Cihlar, Sheldon Broedel, Jr., and Christina Kellogg

    Drug Resistance Mechanisms of Human Pathogenic Fungi

    Rajendra Prasad, Sneh Lata Panwar, and Shankarling Krishnamurthy

    Antifungal Susceptibility Testing: Clinical Interpretations and Utility

    Sofia Perea and Thomas F. Patterson


    Molecular Diagnosis of Fungal Infections

    Roy L. Hopfer and Darius Amjadi

    Serological Approaches to the Diagnosis of Invasive Fungal Infections

    Christine J. Morrison and Mark D. Lindsley

    Molecular Typing and Epidemiology of Candida spp. and Other Important Human Fungal Pathogens

    Derek J. Sullivan and David C. Coleman

    Strain Variation and Clonality in Candida spp. and Cryptococcus neoformans

    Jianping Xu and Thomas G. Mitchell

    New and Emerging Pathogens: What's a Lab to Do? Chester R. Cooper, Jr.


    About the Author

    Calderone\, Richard

    About the Series


    Learn more…

    Subject Categories

    BISAC Subject Codes/Headings:
    SCIENCE / Life Sciences / Botany
    SCIENCE / Life Sciences / Biology / Microbiology
    SCIENCE / Life Sciences / General