G Protein-Coupled Receptors: 1st Edition (Hardback) book cover

G Protein-Coupled Receptors

1st Edition

Edited by Gabriel Berstein

CRC Press

424 pages

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Hardback: 9780849333842
pub: 1999-09-24
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Description

Covering recently developed methods in membrane-bound receptors, this book emphasizes receptor structure and function, knowledge of which is essential to the study of signal transduction.

G Protein-Coupled Receptors has culled contributors from domestic and international sources, providing a broad base of knowledge. Some topics covered are the regulation of receptors; phosphorylation of G-protein-coupled receptors and ion channel receptors; desensitization studies using electrophysiological or confocal microscopic methods and the search for endogenous ligands for orphan receptors.

This volume is useful at both the university and industrial levels, and is of particular interest to those who are developing therapeutic approaches to diseases using drugs that influence receptor activation.

Table of Contents

NOVEL LIGANDS: LIGAND SCREENING SYSTEMS AND ORPHAN RECEPTORS

Measurement of Competitive and Allosteric Interactions in Radioligand Binding Studies-S. Lazareno and N.Birdsall

Ligand Screening of G Protein-Coupled Receptors in Yeast-J. Hadcock and M. Pausch

Ligand Screening Using Melanophore Cells: Frog Skin to Combinatorial Chemistry-J. Quillan and M. Hadley

Screening Orphan Receptors for Native Ligands-S. Wilson, et al.

FUNCTION AND REGULATION: RECEPTOR-G PROTEIN COUPLING AND DESENSITIZATION

Reconstitution of Receptor-Promoted Signal Transduction Using Purified Receptor, G Protein, and Effector-G. Berstein and G. Biddlecome

Mutagenesis Approaches for Studying Receptor-G Protein Interactions and Receptor Assembly-F. Zeng, et al.

G Protein-Coupled Receptor Kinases and Desensitization of Receptors-H. Kurose

Internalization and Down regulation of G Protein-Coupled Receptors-J. Lameh

Use of Electrophysiology to Monitor and Study Receptor Desensitization-M. Boyett, Z. Shui, and I. Khan

3D STRUCTURE: LARGE-SCALE EXPRESSION AND ELECTRON AND X-RAY CRYSTALLOGRAPHY

Expression in Escherichia coli and Large-Scale Purification of a Rat Neurotensin Receptor-R. Grisshammer and J. Tucker

Large-Scale Expression of Receptors in Yeasts-H. Reilander, C. Reinhart, and A. Szmolenszky

Electron Crystallography of Membrane Proteins-Y. Fujiyoshi

X-Ray Crystallography of Membrane Proteins from Detergent Solution: The Structures of a Ligand-Gated Bacterial Membrane Receptor in Two Conformations: a Gallery at Atomic Resolution-K. Locher, B. Rees, D. Moras, and J. Rosenbusch

X-Ray Crystallography of Membrane Proteins: Concepts and Applications of Lipidic Mesophases to Three-Dimensional Membrane Protein Crystallization-M. Loewen. M. Chiu, C. Widmer, E. Landau, J. Rosenbusch, and P. Nollert

About the Authors/Editor

Berstein\, Gabriel

About the Series

Methods in Signal Transduction Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
MED071000
MEDICAL / Pharmacology
SCI086000
SCIENCE / Life Sciences / General
SCI089000
SCIENCE / Life Sciences / Neuroscience