Gene Delivery : Nanotechnology and Therapeutic Applications book cover
1st Edition

Gene Delivery
Nanotechnology and Therapeutic Applications

Edited By

Yashwant Pathak




ISBN 9781032025544
Published June 29, 2022 by CRC Press
246 Pages 18 Color & 4 B/W Illustrations

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Book Description

Gene delivery is a transport of genes of therapeutic values into the chromosomes of the cells or tissues which can be targeted to replace the faulty genes. In last two decades lot of research efforts are dedicated to gene delivery for therapeutic applications. Today gene therapy is promising approach in treatment of genetic diseases including mitochondrial related diseases like blindness, muscular dystrophy, cystic fibrosis, and some cancers.

Gene Delivery Systems: Nano Delivery Technologies observes the exploration of nanotechnology for gene therapy and gene delivery. Written by prominent authors in the field, this book covers various aspects of gene delivery including challenges in delivering gene therapy, advances in genome editing, RNA-based gene therapy, Green nanoparticles for oligonucleotide delivery.

Additional features include"

  • Provides the most up to date information on the development of gene therapy, from the technology involved to gene correction and genome editing.
  • Includes knowledge of the current application of CRISPR/Cas9 gene-editing technique; an approach that has recently been given the Noble Prize.
  • Examines the development of mRNA vaccines for Covid -19 in challenging pandemic scenario
  • Discusses siRNA, mRNA, and DNA plasmids.

 

Table of Contents

Contents

Preface ............................................................................................................................................. ix
Editor ................................................................................................................................................ xi
List of Contributors ...................................................................................................................... xiii

Chapter 1 Challenges in Delivering Gene Therapy.......................................................................1

Divya Sheth and Yashwant V. Pathak

Chapter 2 Advances in Genome Editing: The Technology of Choice for Precise and

Efficient Disease Treatment, with Special Focus on Nano Delivery Systems............15

Komal Parmar and Jayvadan Patel

Chapter 3 Extracellular Vesicles for Nucleic Acid Delivery: Progress and Prospects

for Safe RNA-Based Gene Therapy............................................................................31

Md Meraj Anjum, Dulla Naveen Kumar, Aiswarya Chaudhuri, Sanjay Singh,

and Ashish Kumar Agrawal

Chapter 4 Green Synthesis of Nanoparticles in Oligonucleotide Drug Delivery System............51

Manish P. Patel, Praful D. Bharadia, Kunjan B. Bodiwala,

Mustakim M. Mansuri, and Jayvadan K. Patel

Chapter 5 Development of m-RNA Vaccines in Covid-19 Pandemic Scenario...........................65

Disha Jain and Yashwant Pathak

Chapter 6 Gene Therapy for Cardiovascular Diseases: Clinical Evidence..................................71

Dhwani Thakkar, Vandit Shah, and Jigna Shah

Chapter 7 Current Application of CRISPR/Cas9 Gene-Editing Technique to Eradication of

HIV/AIDS...................................................................................................................85

Prachi Pandey, Jayvadan Patel, and Samarth Kumar

Chapter 8 siRNA Delivery for Therapeutic Applications Using Nanoparticles........................103

Sonia Barua and Yashwant Pathak

Chapter 9 Clinical Perspectives on Gene Therapy for Retinal and Eye Diseases......................115

Devika S. Joshi, Gaurav M. Karve, and Shrikant D. Joshi

Chapter 10 Herpesvirus microRNAs for Use in Gene Therapy Immune-Evasion Strategies......129

Vineet Mahajan, Shruti Saptarshi, and Yashwant Pathak

Chapter 11 Gene Therapy and Small Molecules Used in the Treatment of Cystic Fibrosis........139

Manish P. Patel, Uma G. Daryai, Mansi N. Athalye, Praful D. Bharadia,

and Jayvadan K. Patel

Chapter 12 Non-Viral Delivery of Genome-Editing Nucleases for Gene Therapy.....................163

Sonia Barua and Yashwant Pathak

Chapter 13 CRISPER Gene Therapy Recent Trends and Clinical Applications.........................179

Prachi Pandey, Jayvadan Patel, and Samarth Kumar

Chapter 14 Clinical Applications of Gene Therapy for Immuno-Deficiencies............................195

Khushboo Faldu, Sakshi Gurbani, and Jigna Shah

Chapter 15 Regulatory Challenges for Gene Delivery................................................................207

Vineet Mahajan, Shruti Saptarshi, and Yashwant Pathak

Index ................................................................................................................................................... 221

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Editor(s)

Biography

Dr. Yashwant Pathak completed his Ph.D. in Pharmaceutical Technology from Nagpur University,

India and his EMBA MS in Conflict Management from Sullivan University. He is Professor and

Associate Dean for Faculty Affairs at the College of Pharmacy, University of South Florida. Tampa,

Florida. With extensive experience in academia as well as industry, he has more than 100 publications,

two patents and two patent applications, twenty edited books published, including seven books

in Nanotechnology and six in Nutraceuticals and drug delivery systems. He has several books in cultural

studies and conflict management. He has received several National and International awards.

His recent assignment was Fulbright Senior Fellow in Indonesia for six months, where he traveled

in seven countries and lectured in more than twenty universities. He was a key note speaker at the

World Hindu Wisdom meeting in Bali, Indonesia, in June 2017 and co-chaired with the Governor

of Bali. Dr Yashwant Pathak is also a Professor of Global Health with the College of Public Health

at USF. Recently, his student completed a PhD in Global Health on homeopathy medicine and its

efficacy, a survey of 1274 patients in Pune in India. Dr Pathak is also an adjunct faculty member at

AirLangga University College of Public Health at Surabaya Indonesia.