1st Edition

Gene Regulation and Therapeutics for Cancer

ISBN 9781138712423
Published March 22, 2021 by CRC Press
328 Pages 7 Color & 13 B/W Illustrations

USD $200.00

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Book Description

Differential gene regulation and targeted therapy are the critical aspects of several cancers. This book covers specific gene regulation and targeted therapies in different malignancies. It offers a comprehensive assessment of the transcriptional dysregulation in cancer, and considers some examples of transcriptional regulators as definitive oncogenic drivers in solid tumors, followed by a brief discussion of transcriptional effectors of the programs they drive, and discusses its specific targets. Most targeted therapeutics developed to date have been directed against a limited set of oncogenic drivers, exemplified by those encoding cell surface or cytoplasmic kinases that function in intracellular signaling cascades.

Table of Contents

Programmed Death 1 Receptor (PD-1)-mediated Immunomodulatory Effects in Pancreatic Cancer

Ashu Shah, Catherine Orzechowski and Maneesh Jain

Nuclear Factor Kappa-B: Bridging Inflammation and Cancer

Mohammad Aslam Khan, Girijesh Kumar Patel, Haseeb Zubair, Nikhil Tyagi, Shafquat Azim, Seema Singh, Aamir Ahmad and Ajay Pratap Singh

The S100A7/8/9 Proteins: Novel Biomarker and Therapeutic Targets for Solid Tumor Stroma

Sanjay Mishra, Dinesh Ahirwar, Mohd W. Nasser and Ramesh K. Ganju

Nuclear Receptor Coactivators: Mechanism and Therapeutic Targeting In Cancer

Andrew Cannon, Christopher Thomson, Rakesh Bhatia and Sushil Kumar

Liquid Biopsies for Pancreatic Cancer: A Step Towards Early Detection

Joseph Carmicheal, Rahat Jahan, Koelina Ganguly, Ashu Shah and Sukhwinder Kaur

Targeting Subgroup-specific Cancer Epitopes for Effective Treatment of Pediatric Medulloblastoma

Sidharth Mahapatra and Naveen Kumar Perumal

Aberrant Methylation of UC Promoters in Human Pancreatic Ductal Carcinomas

Michiyo Higashi and Seiya Yokoyama

Receptor Tyrosine Kinase Signaling Pathways as a Goldmine for Targeted Therapy in Head and Neck Cancers

Muzafar A. Macha, Satyanarayana Rachagani, Sanjib Chaudhary, Zafar Sayed, Dwight T. Jones and Surinder K. Batra

Molecular Drivers in Lung Adenocarcinoma: Therapeutic Implications

Imayavaramban Lakshmanan and Apar Kishor Ganti

Molecular Mediator of Prostate Cancer Progression and Its Implication in Therapy

Samikshan Dutta, Navatha Shree Sharma, Ridwan Islam and Kaustubh Datta

Therapeutic Options for Prostate Cancer: A Contemporary Update

Sakthivel Muniyan, Jawed A. Siddiqui and Surinder K. Batra

Regulation and Targeting of MUCINS in Pancreatic Cancer

Shailendra K. Gautam, Grish C. Varshney and Parthasarathy Seshacharyulu

Targeted Therapy for Cancer Stem Cells

Rama Krishna Nimmakayala, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Srikanth Barkeer and Moorthy P. Ponnusamy

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Surinder K. Batra is a Professor and Chairman of the Department of Biochemistry and Molecular Biology at the University of Nebraska Medical Center. Dr. Batra studies the functions of mucins in the progression of different malignancies. His recent studies demonstrated the molecular mechanism for the progression and metastasis of multiple cancers. His investigations led to developing several targeted therapies for different tumors. Based on his mechanistic and translational studies, different targets entered into Phase I/II trials for various cancers.

Moorthy P. Ponnusamy is an Associate Professor of Biochemistry and Molecular Biology at the University of Nebraska Medical Centre. Dr. Ponnusamy’s research background reflects a keen interest in understanding the molecular mechanisms of cancer stem cell-mediated progression and metastatis of pancreatic cancer. His recent studies discovered the specific mechanism for pancreatic cancer stem cell maintenance and its impact on metastatis. He is developing small molecules to target cancer stem cell populations.