This book examines the revolutionary new technology of gene targeting, from its history to its potential application for the genetic treatment of human diseases. It begins with an introduction to the field and a description of the whole gene targeting spectrum. It continues with discussions in the following areas:
Table of Contents
Gene Targeting, W.M. Bertling.
Molecular Mechanisms of Homologous Recombination, A.S. Waldman.
Gene Targeting in Tripanosomatides, A.K. Cruz.
Gene Targeting in Plants, R. Offringa and P. Hooykaas.
Gene Targeting in Mammalian Development and Physiology, T. Lufkin.
Animal Models of Human Genetic Disease, J.-L. Guenet.
Homologous Recombination Proteins and Their Potential Applications in Gene Targeting Technology, S.C. Kowalczykowski and D.A. Zarling.
Gene Targeting in Human Gene Therapy, M.A. Vega.