This multi-authored book provides a unique accounting of the cancer problem from the standpoint of those primary genetic factors which may be interacting with myriad environmental exposures in cancer etiology. It provides a comprehensive coverage of cancer of all anatomical sites in conjunction with a genetic/environmental thrust. It includes a survey chapter dealing with the role of primary genetic factors in cancer of differing anatomic sites and a similar comprehensive survey chapter tracing the history of epidemiology, with focus upon multiple anatomic sites, including classical epidemiologic cancer models such as cigarette smoking, asbestos, vinyl chloride, and uranium exposure. Chapters are devoted to tumor biomarkers and their applicability to cancer of multiple anatomic sites. Clinical correlation will involve surveillance/management programsand focus on high-risk groups-such as those involving primary genetic or environmental factors and/or their interaction. The development of registries involving families with differing hereditary cancer syndromes are considered. Also, many chapters are devoted to environmental protective measures, as well as the need for more responsibility for coverage of patients at inordinately high risk for cancer by third party carriers. Other chapters address segregation and linkage analysis, oncogenes, cytogenetics, and other biomarkers.
This book will be of interest to general clinicians, oncologists, surgeons, geneticists, and carcinogenesis investigators.
Introduction. Biostatistical Methods for the Familial Study of Cancer. Host Variations in Carcinogen Metabolism and DNA Repair. Teratogenesis and Oncogenesis: A Developmental Spectrum. Genetic Epidemiology of Cancer. Cancer Occurrence in Persons with Inborn Errors of Metabolism. Family History and Childhood Malignancies with Special Reference to Genetic Environmental Interaction. Genetic Epidemiology of Retinoblastoma. Xeroderma Pigmentosum: Genetic Epidemiology of a Cancer-Prone Disease. Ataxia Telangiectasia and Other a-Fetoprotein Associated Disorders. The Environment and Cancer-Associated Genodermatoses. Genetic Factors in the Etiology of Esophageal Cancer and the Strategy for Its Prevention in High Incidence Areas of North China. Genetics of Colon Cancer at the Infrahuman Level. Epidemiology of Familial Predisposition to Large Bowel Cancer. Pathology, Genetics, and Management of Hereditary Gastrointestinal Polyposes. Genetic Epidemiology of Colon Cancer. Genetic Epidemiology of Lung Cancer. Genetic Epidemiology of Breast Cancer. Familial Mesothelioma. Biomolecular Genetics of Cancer. Index.