Genetic Toxicology and Cancer Risk Assessment  book cover
1st Edition

Genetic Toxicology and Cancer Risk Assessment

ISBN 9780429207631
Published August 31, 2001 by CRC Press
406 Pages

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Book Description

Presents state-of-the-art regulatory cancer risk assessment models including a biologically based model for two-hit carcinogenesis and cell proliferation!

This book comprehensively reviews the various roles of genetic toxicology in human cancer risk assessment conducted by United States and worldwide regulatory agencies-discussing hazard identification, dose-response relationships, exposure assessment, and current practices of risk characterization.

Examines predictive values of mutagenicity tests, mechanisms of carcinogenesis, and conventional genotoxicity tests required by the International Conference on Harmonization and the Organization for Economic Cooperation and Development/Environmental Protection Agency guidelines!

Comprised of contributions from prominent experts and risk assessors and including nearly 1200 references to facilitate further study, Genetic Toxicology and Cancer Risk Assessment

  • reviews contemporary human cancer genetics as related to the mutagenic nature of carcinogenesis
  • calculates acceptable exposure levels based on a carcinogenic threshold dose for nongenotoxic carcinogens
  • reveals the rationale and methodology of quantitative estimation of human cancer risks using mathematical models
  • discusses the threshold concept of carcinogenesis
  • demonstrates how bacterial mutagenicity assays are the most reliable for predicting rodent carcinogens
  • considers structural activity relationship (SAR) analysis of chemical carcinogenicity
  • describes the emergence of the mouse lymphoma microwell and in vitro micronucleus assays
  • illustrates the use of genetic biomarkers for dosimetry analysis
  • and more!
    Linking human cancer genetics, mutagenicity assays, mechanisms of carcinogenesis, carcinogenic thresholds, molecular epidemiology, mathematical modeling, and quantitative cancer risk analysis, Genetic Toxicology and Cancer Risk Assessment is a must-have reference for toxicologists; oncologists; geneticists; biostatisticians; reproductive, developmental, cell, and molecular biologists; endocrinologists; biochemists; and upper-level undergraduate, graduate, and medical school students in these disciplines.
  • Table of Contents

    Human Cancer Genetics
    Jason W. Barlow and David Malkin
    Genetic Toxicity Tests for Predicting Carcinogenicity
    Errol Zeiger
    Genotoxic and Nongenotoxic Mechanisms of Carcinogenesis
    Wai Nang Choy
    Structure-Activity Relationship (SAR) and its Roles in Cancer Risk Assessment
    David Y. Lai and Yin-tak Woo
    Regulatory Genetic Toxicology Tests
    Wai Nang Choy
    Complementary Genetic Toxicology Assays
    B. Bhaskar Gollapudi
    The Mouse Lymphoma Assay (MLA) Using the Microwell Method
    Masamitsu Honma and Toshio Sofuni
    The In Vitro Micronucleus Assay
    Marilyn J. Aardema and Micheline Kirsch-Volders
    ICH Guidelines on Genotoxicity and Carcinogenicity: Scientific Background and Regulatory Practice
    Lutz Müller, Peter Kasper, and Leonard Schechtman
    New OECD Genetic Toxicology Guidelines and Interpretation of Results
    Michael C. Cimino
    Dose-Response Relationships in Chemical Carcinogenesis and Cancer Risk Assessment
    Werner K. Lutz
    Molecular Epidemiology and Biomarkers
    Jia-Sheng Wang, Jonathan M. Links, John Groopman
    Quantitative Cancer Risk Assessment of Nongenotoxic Carcinogens
    Anna M. Fan and Robert A. Howd
    Risk Assessment of Genotoxic Carcinogens
    Lauren Zeise
    Biologically Based Cancer Risk Assessment Models
    Suresh H. Moolgavkar

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    …engaging and informative….
    …a useful contribution to the field of genetic toxicology.

    …a great reference material.
    "-Australian Journal of Medical Science

    "…offers the reader an authoritative, practical insight.
    "-Cancer Forum