Pharmacokinetics of Drugs in the Elderly
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Gerontokinetics: Pharmacokinetics of Drugs in the Elderly is concerned with the complex processes of how the body handles drugs. After dealing with changes in the anatomy and physiology of the human body with increasing age, the pharmacokinetics of drugs in the elderly is discussed. In particular, five processes are discussed: liberation, absorption, distribution, metabolism and elimination. Finally, guidelines are given for the health care practitioner in evaluating pharmacokinetics in geriatric patients as well as the principles behind dosage adjustment in the aged. More than half the book is devoted to a listing of the pharmacokinetic parameters of drugs which have been studied in the elderly. This volume will be of interest to anyone involved in geriatric medicine or in clinical pharmacokinetics.
Table of Contents
PHYSIOLOGY OF THE AGED. Introduction. Theories of Aging. Physiological Changes Due to Aging. Body Weight and Body Composition. Blood Flow Rates. Blood Chemistry. Receptor Sensitivity and Disease. PHARMACOKINETICS IN THE ELDERLY. Introduction. Liberation. Adsorption, Distribution. Metabolism. Elimination. Clinical Consequences. General Remarks and Guidelines. Receptor Sensitivity. PHARMACOKINETIC PARAMETERS. Introduction. How to Estimate Dosing Rate. How to Estimate Complete Clearance Time. How to Estimate Time to Therapeutic Steady State. Elimination Half. Life Renal Failure.
"A very timely, much-needed text for the clinical pharmacist....strongly recommended."
-The Annals of Pharmacotherapy
"Provides a simple discussion of the physiology of aging and illustrates some fundamental concepts in pharmacokinetics."
-Ontario College of Pharmacists