Glycoproteins play an important role in the regulation of gene expression, cell growth, migration, differentiation and apoptosis. Over the last decade, research has highlighted the therapeutic implications of glycoproteins for many physiological and pathological processes, such as inflammation, arthritis and metastasis. The first part of the book deals with the structure and biosynthesis of glycoconjugates; the second part addresses the pathological roles played by glycoconjugates and their potential therapeutic applications.
General Aspects. Biosynthesis of Membrane Glycoproteins. Structure and Analysis of Glycoprotein-Associated Oligosaccharides. General Overview of the Structure, Synthesis and Degradation of Glycosaminoglycans and Glycolipids. Basement Membrane and Extracellular Matrix Organization. Membrane Lectins as Adhesion Receptors. Relevance to Pathology and Therapeutic Aspects. The Involvement of Bisecting N-Acetylglucosamine in Cancer. 1,6 N-Acetylglucosaminyltransferase V is a Determinant of Cancer Growth and Metastasis. ,(1-6)-N-Acetylglucosamine-Branched N-Glycans in Normal and Pathological Lymphocyte Behavior. Roles of Glycans in Bacterial Infections: Interaction Host-Mycobacteria. Meuropathologies Involving Endogenous Lectins and the Ligands. Low-Tech Mannose Therapy for Protein Glycosylation Deficiencies. Glycoconjugates as Vectors for Gene and Oligonucleotide Delivery. Index.