"Presents state-of-the-art methods for the synthesis, analysis, and conformational investigation of glycoproteins and glycopeptides. Discusses the history of glycopeptide synthesis, therapeutic applications, and the future of research."
"This is a very special book. . . Every school with a graduate program in organic chemistry should have this book in its library. "
---Journal of Medicinal Chemistry
". . .a valuable resource. "
---The European Peptide Society Newsletter
". . .a valuable manual for specialists in the fields of biochemistry, bioorganic chemistry, synthetic chemistry, pharmacology, and interdisciplinary sciences."
Glycopeptides and glycoproteins - their past, present, and future; recent advances in the synthesis of glycopeptides; enzymatic synthesis of oligosaccharides and glycopeptides; chemical synthesis of glycoprotein glycans; synthesis of oligosaccharides and glycopeptides on insoluble and soluble supports; chemical synthesis of the peptide moiety of glycopeptides; synthesis of glycosylphosphatidylinositol anchors; analysis of GPI protein anchors and related glycolipids; synthesis of intermediates in the dolichol pathway of protein glycosylation; synthesis of inhibitors of the glycosidases and glycosyltransferases involved in the biosynthesis and degradation of glycoproteins; use of permethylation with GC-MS for linkage and sequence analysis of oligosaccharides historical perspectives and recent developments; structural determination of protein-bound oligosaccharides by mass spectrometry; approaches to the structural determination of oligosaccharides and glycopeptides by NMR; conformational studies of glycoprotein glycans using NMR and molecule dynamics; glycopeptides in the immunotherapy of cancer.