Graft vs. Host Disease: 3rd Edition (Hardback) book cover

Graft vs. Host Disease

3rd Edition

Edited by James Ferrara, H. Joachim Deeg, Kenneth R. Cooke, James Ferrara, Kenneth R. Cooke, H. Joachim Deeg

CRC Press

672 pages

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Hardback: 9780824754723
pub: 2004-12-17
eBook (VitalSource) : 9780429135729
pub: 2004-12-17
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With detailed contributions from more than 40 leading authorities on the topic, this Third Edition comprehensively explores the immunobiology, pathophysiology, and clinical manifestations of graft-versus-host disease (GVHD)-offering sections revealing the most up-to-date research on immune activation and dysregulation, the pathophysiology of target organ damage, and GVHD prevention and treatment.


"…This excellent book gives a comprehensive account of GvHD that will be an invaluable source of reference for transplantation biologists and all clinicians involved in bone marrow transplantation."

-Molecular Medicine Today

"…The book captures most of the recent new evidence, controversies, speculation, and promising future directions of work aimed at avoiding this highly morbid post-transplant illness….recommended."

-Doody's Journal

"…Numerous investigators have contributed their expertise to this third edition of the book to provide a comprehensive overview and update on recent developments in our understanding and the management of GvHD."

-E. Donnall Thomas, M.D.

Table of Contents

The Pathophysiology of Graft-vs.-Host Disease. Animal Models of Graft-vs.-Host Disease. Graft-vs.-Host Disease as a Th1-Type Process: Regulation by Th2-Type Cells. Role of T-Cell Costimulation and Regulatory Cells in Allogeneic Hematopoietic Cell Transplantation. Chemokines and Graft-vs.-Host Disease. Graft-vs.-Leukemia Effects. The Immune System in Graft-vs.-Host Disease: Target and Effector Organ. Pathology and Pathogenesis of Cutaneous Graft-vs.-Host Disease. Graft-vs.-Host Disease of the Liver. Intestinal Graft-vs.-Host Disease. The Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation. Clinical Spectrum of Acute Graft-vs.-Host Disease. Role of Minor Histocompatibility Antigens in the Development of Graft-vs.-Host Disease and Graft-vs.-Leukemia Reactivity. Advances in Tissue Typing and Their Potential Impact on GVHD Incidence and Severity. Immunosuppression and Immunophilin Ligands: Cyclosporin, Tacrolimus, and Sirolimus. Prophylaxis and Treatments of Acute Graft-vs.-Host Disease. Graft Manipulation to Prevent Graft-vs.-Host Disease. Graft-vs.-Host Disease in Nonmyeloablative Transplant. Adoptive Immunotherapy in Stem Cell Transplantation. Clinical Spectrum and Therapeutic Approaches to Chronic Graft-vs.-Host Disease. Recent Advances and Future Directions.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology