Handbook for Chemical Process Research and Development: 1st Edition (Hardback) book cover

Handbook for Chemical Process Research and Development

1st Edition

By Wenyi Zhao

CRC Press

810 pages | 1446 B/W Illus.

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Hardback: 9781498767996
pub: 2016-09-27
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The Handbook for Chemical Process Research and Development focuses on developing processes for chemical and pharmaceutical industries. Forty years ago there were few process research and development activities in the pharmaceutical industry, partially due to the simplicity of the drug molecules. However, with the increasing structural complexity, especially the introduction of chiral centers into the drug molecules and strict regulations set by the EMA and FDA, process R&D has become one of the critical departments for pharmaceutical companies. This book assists with the key responsibility of process chemists to develop chemical processes for manufacturing pharmaceutical intermediates and final drug substances for clinical studies and commercial production.

Table of Contents

  • Chapter 1: Modes Of Reagent Addition – Control of Impurity Formation
  • Chapter 2: Process Optimization
  • Chapter 3: Hazardous Reactions
  • Chapter 4: Catalytic Reactions
  • Chapter 5: Grignard Reagent And Related Reactions
  • Chapter 6: Challenging Reaction Intermediates
  • Chapter 7: Protecting Groups
  • Chapter 8: Reaction Solvents
  • Chapter 9: Base Reagent Selection
  • Chapter 10: Reagents For Amide Formation
  • Chapter 11: Various Reagent Surrogates
  • Chapter 12: Telescope Approach
  • Chapter 13: Stereochemistry
  • Chapter 14: Design Of New Synthetic Route
  • Chapter 15: Reaction Workup
  • Chapter 16: Pharmaceutical Salts
  • Chapter 17: Solid Form

About the Author


Wenyi Zhao

Plainsboro, New Jersey, USA

Learn more about Wenyi Zhao >>

Dr. Wenyi Zhao holds a PhD in Organic/Physical Chemistry from Nanjing University, China. After completing postdoctoral fellowships at the Chinese Academy of Sciences and Texas Tech University, he moved into the private sector to become a process chemist in the pharmaceutical industry in the US with over 15 years of experience. He is the author of numerous journal articles and holds several patents.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
SCIENCE / Chemistry / Organic
SCIENCE / Chemistry / Industrial & Technical