Handbook of Comparative Veterinary Pharmacokinetics and Residues of Pesticides and Environmental Contaminants: 1st Edition (Hardback) book cover

Handbook of Comparative Veterinary Pharmacokinetics and Residues of Pesticides and Environmental Contaminants

1st Edition

By Stephen F. Sundlof, Jim E. Riviere, Arthur L. Craigmill

CRC Press

592 pages

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Hardback: 9780849332135
pub: 1995-11-03
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Description

Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume.

For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.

Table of Contents

Principles of Pharmacokinetics

Introduction

Drug Disposition Overview

Distribution

Elimination

Absorption

Pharmacokinetics

Compartmental Systems

Multiple Dose Administration

Extravascular Drug Administration

Statistical Considerations

Principles of Interspecies Extrapolation

Selected Readings and References

Orientation to Chapters and Tables

Chlorinated Hydrocarbon Insecticides

Introduction and Selected Readings

Table 3A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 3B: Pharmacokinetic Data for Drugs in Other Matrices

References

Organophosphate and Carbamate Insecticides

Introduction and Selected Readings

Table 4A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 4B: Pharmacokinetic Data for Drugs in Other Matrices

References

Herbicides

Introduction and Selected Readings

Table 5A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 5B: Pharmacokinetic Data for Drugs in Other Matrices

References

Rodenticides

Introduction and Selected Readings

Table 6A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 6B: Pharmacokinetic Data for Drugs in Other Matrices

References

Miscellaneous Pesticides and Antidotes

Introduction and Selected Readings

Table 7A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 7B: Pharmacokinetic Data for Drugs in Other Matrices

References

Mycotoxins

Introduction and Selected Readings

Table 8A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 8B: Pharmacokinetic Data for Drugs in Other Matrices

References

Environmental Contaminants

Introduction and Selected Readings

Table 9A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood

Table 9B: Pharmacokinetic Data for Drugs in Other Matrices

References

Appendix A: FDA Approved Tolerances and Action Levels

Appendix B: Chemical Structures and Physicochemical Properties

Index

Subject Categories

BISAC Subject Codes/Headings:
MED089000
MEDICAL / Veterinary Medicine / General
MED096000
MEDICAL / Toxicology