Handbook of Comparative Veterinary Pharmacokinetics and Residues of Pesticides and Environmental Contaminants  book cover
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Handbook of Comparative Veterinary Pharmacokinetics and Residues of Pesticides and Environmental Contaminants



ISBN 9780849332135
Published November 3, 1995 by CRC Press
592 Pages

 
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Book Description

Residues of drugs and chemicals in edible tissues of food-producing animals are a major public health concern. Until now, information on applications of pharmacokinetic principles to drug and chemical residue avoidance has been spread throughout literature. For the first time, this handbook brings this information together in a convenient and concise volume.
For easier reference, text is divided into three parts: physicochemical constants and chemical structures, legal tissue tolerances, and pharmacokinetic parameters derived from open literature. This is the only publication that offers all this information in a single source. For fast access, numerous tables present valuable pharmacokinetic data for drugs in serum, plasma, or blood and in other matrices. The authors include their own previously unpublished pharmacokinetic parameters, results of statistical analyses performed on time/concentration data tabulated in the primary sources. Helpful appendices contain FDA approved tolerances and action levels as well as chemical structures and physicochemical properties. This is an essential handbook for veterinarians, toxicologists, pharmacologists, animal scientists, food hygienists, and regulatory personnel involved in human food safety.

Table of Contents

Principles of Pharmacokinetics
Introduction
Drug Disposition Overview
Distribution
Elimination
Absorption
Pharmacokinetics
Compartmental Systems
Multiple Dose Administration
Extravascular Drug Administration
Statistical Considerations
Principles of Interspecies Extrapolation
Selected Readings and References
Orientation to Chapters and Tables
Chlorinated Hydrocarbon Insecticides
Introduction and Selected Readings
Table 3A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 3B: Pharmacokinetic Data for Drugs in Other Matrices
References
Organophosphate and Carbamate Insecticides
Introduction and Selected Readings
Table 4A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 4B: Pharmacokinetic Data for Drugs in Other Matrices
References
Herbicides
Introduction and Selected Readings
Table 5A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 5B: Pharmacokinetic Data for Drugs in Other Matrices
References
Rodenticides
Introduction and Selected Readings
Table 6A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 6B: Pharmacokinetic Data for Drugs in Other Matrices
References
Miscellaneous Pesticides and Antidotes
Introduction and Selected Readings
Table 7A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 7B: Pharmacokinetic Data for Drugs in Other Matrices
References
Mycotoxins
Introduction and Selected Readings
Table 8A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 8B: Pharmacokinetic Data for Drugs in Other Matrices
References
Environmental Contaminants
Introduction and Selected Readings
Table 9A: Pharmacokinetic Data for Drugs in Serum, Plasma, or Blood
Table 9B: Pharmacokinetic Data for Drugs in Other Matrices
References
Appendix A: FDA Approved Tolerances and Action Levels
Appendix B: Chemical Structures and Physicochemical Properties
Index

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