Handbook of Drug Metabolism: 1st Edition (Paperback) book cover

Handbook of Drug Metabolism

1st Edition

Edited by Thomas Woolf

CRC Press

612 pages

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Paperback: 9780367399856
pub: 2019-06-19
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Hardback: 9780824702298
pub: 1999-03-29
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Bringing together nearly forty collaborators from academic and industrial laboratories, this reference furnishes an overview of the subject from a historical, kinetic, and chemical context. A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development. Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P450, explains clearance, volume of distribution, sequential metabolism, and nonlinear kinetics, summarizes concepts of Phase 1 and 2 metabolites, evaluates tertiary amine metabolism and reactive metabolite chemistry, and more.

Table of Contents

Fundamental Aspects of Drug Metabolism. Factors Affecting Drug Metabolism. Technologies. Metabolism in Drug Discovery and Development.

About the Editor

Thomas F. Woolf

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
MEDICAL / Pharmacy
SCIENCE / Chemistry / General