1st Edition

Handbook of Imaging in Biological Mechanics

Edited By Corey P. Neu, Guy M. Genin Copyright 2015
    579 Pages 127 Color & 294 B/W Illustrations
    by CRC Press

    Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens at the nanoscale.

    The Handbook of Imaging in Biological Mechanics presents the spectrum of imaging techniques used for noninvasive visualization of the morphology and mechanics of the large and small—from organs to individual macromolecules.

    The handbook presents optimal imaging technologies to study deformation, stress, and constitutive behavior of tissues, cells, and proteins. It also describes a suite of technologies available for probing the mechanics of surfaces, membranes, and single molecules. With chapters authored by highly recognized experts in their area, the handbook covers the entire spectrum of biomechanical and mechanobiologic imaging technologies available today.

    INTRODUCTION

    Imaging in Biological Mechanics; Corey P. Neu and Guy M. Genin

    TISSUE AND ORGAN IMAGING METHODS: MAGNETIC RESONANCE IMAGING METHODS

    MRI Tagging of the Heart; Leon Axel and Solae Chung

    Frequency-Domain Analysis of Tagged MRI and Imaging Strategies; Khaled Z. Abd-Elmoniem, Vijay Parthasarathy, and Jerry L. Prince

    Magnetic Resonance Elastography; Jiming Zhang and Raja Muthupillai

    Magnetic Resonance Elastography of the Brain; Philip V. Bayly, Erik H. Clayton, Guy M. Genin, and Ruth J. Okamoto

    Displacements under Applied Loading by MRI in Soft Biomaterials and Tissues; Corey P. Neu

    TISSUE AND ORGAN IMAGING METHODS: ULTRASOUND

    Ultrasound and Optical Methods for Dynamic Viscoelastic Imaging; Yue Wang, Steven G. Adie, Stephen A. Boppart, and Michael F. Insana

    Ultrasound Imaging of Mechanical Properties of Cancers; Brian S. Garra

    TISSUE AND ORGAN IMAGING METHODS: RADIOGRAPHY AND COMPUTED TOMOGRAPHY

    Computed Tomography Image-Based Kinematic Analysis: An Overview; Douglas C. Moore, Eni Halilaj, Tarpit K. Patel, and Joseph J. Crisco III

    Contrast-Enhanced MicroCT Imaging; David Reece, Angela Lin, and Robert E. Guldberg

    TISSUE AND ORGAN IMAGING METHODS: HIGH THROUGHPUT AND IMAGE QUANTIFICATION

    Application of Digital Image Correlation for Multiscale Biomechanics; Hui Wang, William Lai, Antonia Antoniou, and Ashraf Bastawros

    Image-Based Estimation of Passive Myocardial Properties Using Finite Element Modeling; Alexander I. Veress, Benjamin R. Coleman, Genevieve Farrar, W. Paul Segars, and Brian C. Fabien

    Particle Image Velocimetry for Biological Mechanics; Zachary J. Taylor, Roi Gurka, and Alex Liberzon

    High-Throughput Imaging Methodologies for Biomechanical Testing; Yu Long Han, Guoyou Huang, Lin Wang, Xiaoxi Fan, Fei Li, Pengfei Wang, Tian Jian Lu, and Feng Xu

    TISSUE AND ORGAN IMAGING METHODS: MULTISCALE IMAGING AND MODELING

    Nonlinear and Poroelastic Biomechanical Imaging: Elastography Beyond Young’s Modulus; Paul E. Barbone, Assad A. Oberai, Jeffrey C. Bamber, Gearóid P. Berry, Jean-François Dord, Elizabete Rodrigues Ferreira, Sevan Goenezen, and Timothy J. Hall

    Quantitative Anatomy Using Design-Based Stereology; Peter R. Mouton

    Brain Shift Compensation via Intraoperative Imaging and Data Assimilation; Songbai Ji, Xiaoyao Fan, David W. Roberts, Alex Hartov, Timothy J. Schaewe, David A. Simon, and Keith D. Paulsen

    Noninvasive Determination of Material Properties for Biological Materials; Kent Butz, Deva Chan, Corey P. Neu, and Eric A. Nauman

    CELLULAR AND MOLECULAR IMAGING METHODS: MICROENVIRONMENTS: NATIVE ECM

    Nonlinear Optical Microscopy in Biomechanics; Jessica C. Mansfield, James S. Bell, Julian Moger, and C. Peter Winlove

    Collagen–Cell Interactions in Three-Dimensional Microenvironments; Sherry L. Voytik-Harbin and Bumsoo Han

    Integrated Modeling and Imaging for Quantifying the Mechanics of Cells in Three-Dimensional Culture; Guy M. Genin and Elliot L. Elson

    CELLULAR AND MOLECULAR IMAGING METHODS: MICROENVIRONMENTS: IN VITRO CULTURE SYSTEMS

    Measurement of Cellular Forces via Traction Force Microscopy; Wesley R. Legant

    Cell Interactions in Wire (Fiber)-Based Structures and Scaffolds; Kevin Sheets, Puja Sharma, Brian Koons, and Amrinder Nain

    Mechanical Stretch Assays in Cell Culture Systems; Abhishek Tondon, Candice Haase, and Roland Kaunas

    CELLULAR AND MOLECULAR IMAGING METHODS: CELLULAR AND SUBCELLULAR BIOPHYSICS

    Micropipette Aspiration and Subcellular Biophysics; Baoyu Liu and Jin-Yu Shao

    Scanning Probe Investigation of Cellular and Subcellular Biomechanics; Sirimuvva Tadepalli, Keng-Ku Liu, and Srikanth Singamaneni

    Fluorescence-Based Tools for Quantifying Adhesion Dynamics; Haguy Wolfenson

    Nanoscale Mechanical Testing of FIB-Isolated Biological Specimens; Ines Jimenez-Palomar, Russell J. Bailey, and Asa H. Barber

    Imaging Cellular Mechanotransduction Using FRET-Based Biosensors; Qiaoqiao Wan, Yu-Hui Lai, and Sungsoo Na

    Intracellular Particle Tracking Microrheology; Michelle R. Dawson, Yiider Tseng, Jerry S.H. Lee, and Kathleen M. McAndrews

    CELLULAR AND MOLECULAR IMAGING METHODS: NUCLEAR BIOPHYSICS

    Probing Chromatin Structure and Dynamics Using Fluorescence Anisotropy Imaging; Ekta Makhija, K. Venkatesan Iyer, Shefali Talwar, and G.V. Shivashankar

    Nuclear Imaging in Mechanobiology; Irena L. Ivanovska, Joe Swift, Jerome Irianto, Kyle Spinler, Jae-Won Shin, Amnon Buxboim, and Dennis E. Discher

    Intranuclear Measurement of Deformation in Single Cells; Jonathan T. Henderson and Corey P. Neu

    CELLULAR AND MOLECULAR IMAGING METHODS: CHANNELS

    Fluorescence Methods for Monitoring Mechanosensitive Channels; Alexander Macmillan, Charles G. Cranfield, and Boris Martinac

    Channel Activation and Mechanotransduction; Henry J. Donahue, Randall L. Duncan, and Damian C. Genetos

    CELLULAR AND MOLECULAR IMAGING METHODS: SURFACES AND SINGLE MOLECULE MEASUREMENTS

    Characterization of Intermolecular and Intramolecular Interactions with the Atomic Force Microscope; Gil U. Lee, Krasimir Ivanov, Devrim Kilinc, Elena Martines, Agata Blasiak, Peng Li, and Michael J. Higgins

    Characterization of Biomolecular Interactions with the Surface Forces Apparatus; Marina Ruths, Carlos Drummond, and Jacob N. Israelachvili

    Magnetic Tweezers Force Spectroscopy; Eric A. Galburt

    Analytical Electron Microscopy of Bone and Mineralized Tissue; Michal Klosowski, Alexandra E. Porter, Sandra J. Shefelbine, and David W. McComb

    Optical Microscopy Methods for Measuring Structure and Dynamic Processes of Cells and Tissues; Elliot L. Elson

    FABLE and Image Processing; Ali Nekouzadeh and Niloufar Ghoreishi

    Biography

    Corey Neu directs the Soft Tissue Bioengineering Laboratory at Purdue University and holds an appointment on the faculty in Purdue’s Weldon School of Biomedical Engineering. He earned a PhD in biomedical engineering from the University of California, Davis. Dr. Neu studies force transfer in cells and tissues in the context of disease and regeneration. His current research focuses on structural and mechanical changes to articular cartilage in the pathogenesis of osteoarthritis, and multiscale biomechanics and mechanobiology of collagen-rich tissues.

    Guy Genin holds appointments on the faculty of the Department of Mechanical Engineering and Materials Science at Washington University in St. Louis, and the Department of Neurosurgery at the Washington University School of Medicine. Dr. Genin earned his PhD in applied and solid mechanics from Harvard University. He studies interfaces and adhesion in nature, physiology, and engineering. He is the recipient of numerous awards for engineering design, teaching, and research, including a Research Career Award from the National Institutes of Health and the Skalak Award from the American Society of Mechanical Engineers.