Laboratory animal testing provides most of our current knowledge of human physiology, microbiology, immunology, pharmacology, and pathology. From studies of genetics in fruit flies to studies of cellular processes in genetically modified mice to recent dramatic developments in genetics, translational research, and personalized medicines, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences and all rely on access to high-quality laboratory animals as models for humans.
Rooted in the principle that good science can only be performed in environments that promote good animal welfare, this third edition of the bestselling Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices emphasizes the importance of implementing the three R’s: replacing live animals with alternative methods, reducing the number of animals used, and refining techniques to minimize animal discomfort, and integrates these humane principles into almost every chapter.
See what's new in the Third Edition:
- New chapters: Applications of Radio-Telemetry in Small Laboratory Animals, Generation and analysis of genetically modified mice, and Physiological, Hematological, and Clinical Chemistry Parameters
- Additional mateiral on the international harmonization of practices and on the continued implementation of the refinement, reduction, and replacement of animal usage in laboratories
- Sixteen page color insert
Relevant to virtually all areas of laboratory science and forming the cornerstone of laboratory animal science, each individual chapter focuses on an important subdiscipline of laboratory animal science including humane laws and guidelines; non-surgical, surgical, microsurgical, and post-mortem procedures; genetic modification; nutrition, feeding, and environmental factors; experiment design and alternative methods; and analgesia, anesthesia, and euthanasia. Each chapter can be read in series or as a stand alone text.
A truly international effort from world renowned contributors, Handbook of Laboratory Animal Science, Vol. 1, Essential Principles and Practices, Third Edition is useful as a textbook in laboratory animal science courses for postgraduate and undergraduate students, as a handbook for scientists who work with animals in their research, and for university veterinarians, regulators, and other specialists in laboratory animal science.
Table of Contents
The Contribution of Laboratory Animals to Medical Progress — Past, Present, and Future, John D. Harding, Gerald L. Van Hoosier, and Franziska B. Grieder
Ethics of Animal Research, I. Anna S. Olsson, Paul Robinson, and Peter Sandøe
An Overview of Global Legislation, Regulation and Policies, Kathryn Bayne, Bryan R. Howard, Tsutomu Miki Kurosawa, and Maria Eugenia Aguilar Nájera
Assessment of Animal Care and Use Programs and Facilities, Javier Guillen, Letty V. Medina, and James R. Swearengen
Education and Training, Nicole Duffee, Timo Nevalainen, and Jann Hau
Laboratory Animal Science and Service Organizations, Patri Vergara and Gilles Demers
Laboratory Animal Allergy and Zoonoses, Richard M. Preece and Anne Renström
Laboratory Animal Facilities and Equipment for Conventional, Barrier, and Containment Housing Systems, Jack R. Hessler
Laboratory Animal Genetics and Genetic Quality Control, Michael F.W. Festing and Cathleen Lutz
Health Status and Health Monitoring, Axel Kornerup Hansen
Nutrient Requirements, Experimental Design, and Feeding Schedules in Animal Experimentation, Jo H. A. J. Curfs, André Chwalibog, Bart S. Savenije, and Merel Ritskes-Hoitinga
Impact of the Biotic and Abiotic Environment on Animal Experiments, Nancy A. Johnston and Timo Nevalainen
Experimental Design and Statistical Analysis, Michael F.W. Festing
Common Nonsurgical Techniques and Procedures, Vera Baumans and Cynthia A. Pekow
Applications of Radio-Telemetry in Small Laboratory Animals, Klaas Kramer and Steve Hachtman
Immunization for Production of Antibodies, Jann Hau and Coenraad Hendriksen
Laboratory Animal Analgesia, Anesthesia, and Euthanasia, Ludo J. Hellenbrekers and Patricia Hedenqvist
Welfare Assessment and Humane Endpoints, David B. Morton and Jann Hau
Surgery: Basic Principles and Procedures, M. Michael Swindle, Heather Elliott, and Alison C. Smith
Microsurgical Procedures in Experimental Research, Daniel A. Steinbrüchel
Postmortem Procedures, Ricardo E. Feinstein and Kimberly S. Waggie
Alternatives: Refinement, Reduction and Replacement of Animal Uses in the Life Sciences, Lisbeth E. Knudsen, Marlies Leenaars, Bart Savenije, and Merel Ritskes-Hoitinga
Generation and Analysis of Genetically Modified Mice, Cord Brakebusch
Physiological, Hematological, and Clinical Chemistry Parameters (Including Conversion Factors), Grete Østergaard, Helle Nordahl Hansen, and Jan Lund Ottesen
"… this book is an impressive and valuable contribution to the literature. While not light-reading it is extremely well-written and clear. The chapters provide authoritative introductions to a wide range of animal models and, as such, it will be a very useful resource for researchers, laboratory animal veterinarians and regulators, for those teaching laboratory animal science, as well as to any with an interest in the variety of uses to which animals are put in the biomedical sciences."
— Robert Hubrecht, UFAW, Wheathampstead, UK, in Animal Welfare, February 2012
"[A] valuable reference book, and potentially a course book for undergraduate and graduate laboratory animal science courses. … [T]he text is well organized and well referenced. I would highly recommend this book as a reference text for all scientists using traditional laboratory animal species … ."
—Contemporary Topics in Laboratory Animal Science, Vol. 43, No. 5, Sept. 2004
"Both volumes of this book are well written, user friendly … it fills a current void by collecting together current practices in the scientific use of animals. Each chapter is well referenced and the book would be a valuable addition to the reference collections of animal facilities and research establishments."
—Bryan Howard, Animal Welfare, 2004
"Hau and Van Hoosier have drawn together information of the highest quality … both volumes of this book will be valuable additions to the shelves of any veterinary surgeon involved in the field, either as a named vet or as a member of the multidisciplinary scientific team required in modern biomedical research."
—Paul Townsend, The Veterinary Record, May 31, 2003
"The text is quite easy to navigate using the chapter contents and index. The photographs and tables are clear and well used throughout. …The vast scope of information that this handbook contains is diverse, informative, and quite useful. The strength of these volumes is in their ability to cover a broad range of topics yet in such detail. This set would be an asset to the graduate student and researcher needing an excellent reference manual."
—Sandra L. Jex, Animal Lab News, July/Aug 2003