While replacing and reducing the use of laboratory animals are integral parts of the 3Rs—replace, reduce, refine—which form the cornerstones of laboratory animal science, biomedical research involving animals remains absolutely essential for the advancement of the medical, veterinary, agricultural, and biological sciences. Building upon the bestselling previous edition, the Handbook of Laboratory Animal Science, Volume III, Third Edition: Animal Models complements volumes I and II of the third edition by completing the task of providing a comprehensive overview of animal models in all biomedical disciplines.
The three Rs have been integrated throughout this handbook to promote efficient and humane experimental work with animals. Written by international experts, each chapter focuses on an important subdiscipline of laboratory animal science and can be used as a stand-alone text. This volume contains new chapters for six additional disease animal models: spinal cord injury, cardiovascular diseases, sudden infant death syndrome, developmental disorders, eye diseases, and human cancer. It also presents a new chapter on applying reduction and refinement to animal models.
This handbook can be used for undergraduate and postgraduate laboratory animal science courses, and as a handbook for scientists who work with animals in their research, for university veterinarians, for regulators, and for other specialists in laboratory animal science.
Table of Contents
Animal Models of Spinal Cord Injury
Michelle A. Hook
Animal Models for Tropical Parasitic Diseases
Idle Farah, Maina Ngotho, John Kagira, Thomas Kariuki, Maamun Jeneby, Naomi Maina, Michael Gicheru, Hastings Ozwara, and Jann Hau
Animal models of cardiovascular disease
Animal Models of Sudden Infant Death Syndrome
More Animal Models of Developmental Processes and Developmental Disorders for Social Genomics and Beyond
Matthew F. S. X. Novak and Dorothy J. Mandell
Animal Models of Metabolic and Inflammatory Diseases
Axel Kornerup Hansen
Animal Models for Eye Diseases
Takeshi Iwata, Ph.D.
Animal Models of Human Cancer
Lezlee G. Coghlan
Reduction and Refinement Applied to Animal Models
Jann Hau and Steven J. Schapiro
Jann Hau is a professor of comparative medicine at the University of Copenhagen in Denmark. Dr. Hau has published more than 200 peer-reviewed papers in comparative medicine and chapters in books, and he is frequently invited to speak at international conferences and symposia. He is the recipient of prizes awarded for his research and contributions to animal welfare.
Steven J. Schapiro is an associate professor of comparative medicine in the Department of Veterinary Sciences at the Michale E. Keeling Center for Comparative Medicine and Research of the University of Texas M. D. Anderson Cancer Center. He is one of the founding faculty members of the Primate Training and Enrichment Workshops. Dr. Schapiro has published approximately 140 peer-reviewed papers and book chapters examining various aspects of nonhuman primate behavior, management, and research.
Praise for the previous volumes:
"The strength of these volumes is in their ability to cover a broad range of topics, yet in such detail. This set would be an asset to the graduate student and researcher needing an excellent reference manual."
—Sandra L. Jex, Animal Lab News