1st Edition

Handbook of Lipid Membranes Molecular, Functional, and Materials Aspects

Edited By Cyrus R. Safinya, Joachim O. Rädler Copyright 2021
    376 Pages 100 Color & 61 B/W Illustrations
    by CRC Press

    376 Pages 100 Color & 61 B/W Illustrations
    by CRC Press

    This handbook provides a unique overview of lipid membrane fundamentals and applications. The fascinating world of lipids that harbor and govern so many biological functionalities are discussed within the context of membrane structures, interactions, and shape evolution. Beyond the fundamentals in lipid science, this handbook focuses on how scientists are building bioinspired biomimetic systems for applications in medicine, cosmetics, and nanotechnology.

    Key Features:

    • Includes experimental and theoretical overviews on the role of lipids, with or without associated biomolecules, as structural components imparting distinct membrane shapes and intermembrane interactions
    • Covers the mechanisms of lipid-membrane curvature, by peptide and protein binding, and the roles of signalling lipids and the cytoskeleton in plasma membrane shape evolution
    • Covers advanced X-ray and force measurement techniques
    • Discusses applications in biomedicine, cosmetics, and nanotechnology, including lipid vectors in nucleic acid, drug delivery in dermal applications, and lipid-based sensors and artificial biointerfaces
    • Covers artificial membranes from block copolymers, synthetic copolypeptides, and recombinant proteins
    • Includes an exciting section that explores the role of lipids in the origin of life in hydrothermal conditions

    This book is a highly informative companion for professionals in biophysics, biochemistry, physical chemistry, and material and pharmaceutical sciences and bioengineering.




    Chapter 1 A Short History of Membrane Physics

    Erich Sackmann and Avinoam Ben-Shaul

    Chapter 2 Structures and Interactions in Freely Suspended Multilayer Membranes and Dilute Lamellar Fluid Membranes from Synchrotron X-Ray Scattering

    Gregory S. Smith and Cyrus R. Safinya

    Chapter 3 Structures of Lipid Membranes: Cubic and Inverse Hexagonal Phases

    Charlotte E. Conn and John M. Seddon

    Chapter 4 Structure of Lipid Membranes by Advanced X-Ray Scattering and Imaging

    Tim Salditt

    Chapter 5 Adhesion Protein Architecture and Intermembrane Potentials: Force Measurements and Biological Significance

    Deborah E. Leckband

    Chapter 6 Charged Membranes: Poisson・Boltzmann Theory, the DLVO Paradigm, and Beyond

    Tomer Markovich, David Andelman, and Rudolf Podgornik

    Chapter 7 Membrane Shape Evolution In Vitro

    Alexandra Zidovska

    Chapter 8 Mechanisms of Membrane Curvature Generation by Peptides and Proteins: A Unified Perspective on Antimicrobial Peptides

    Michelle W. Lee, Nathan W. Schmidt, and Gerard C. L. Wong

    Chapter 9 Lipid Membrane Shape Evolution and the Actin Cytoskeleton

    David R. Slochower, Yu-Hsiu Wang, Ravi Radhakrishnan, and Paul A. Janmey

    Chapter 10 Effects of Osmotic Stress on Topologically Closed Membrane Compartments

    James C. S. Ho, Bo Liedberg, and Atul N. Parikh

    Chapter 11 Cationic Liposomes as Spatial Organizers of Nucleic Acids in One, Two, and Three Dimensions: Liquid Crystal Phases with Applications in Delivery and Bionanotechnology

    Cyrus R. Safinya, Kai K. Ewert, Youli Li, and Joachim O. Rädler

    Chapter 12 Lipids in DNA, RNA, and Peptide Delivery for In Vivo Therapeutic Applications

    Tyler Goodwin and Leaf Huang

    Chapter 13 Electrostatics of Lipid Membranes Interacting with Oppositely Charged Macromolecules

    Guilherme Volpe Bossa, Klemen Bohinc, and Sylvio May

    Chapter 14 Lipid-Based Bioanalytical Sensors

    Marta Bally, Hudson Pace, and Fredrik Hook

    Chapter 15 Lipids in Dermal Applications: Cosmetics and Pharmaceutics

    Jerome Bibette and Abdou Rachid Thiam

    Chapter 16 Supported Lipid Bilayers

    Theo Lohmuller, Bert Nickel, and Joachim O. Rädler

    Chapter 17 Artificial Membranes Composed of Synthetic Copolypeptides

    Timothy J. Deming

    Chapter 18 Synthetic Membranes from Block Copolymers, Recombinant Proteins, and Dendrimers

    Daniel A. Hammer, Zhichun Wang, Ellen Reed, Chen Gao, and Kevin B. Vargo

    Chapter 19 Amphiphilic Self-Assembly and the Origin of Life in Hydrothermal Conditions

    Christos D. Georgiou and David W. Deamer



    Cyrus R. Safinya is professor of physics at the University of California, Santa Barbara, USA.

    Joachim O. Rädler is professor of experimental physics at Ludwig-Maximilians-Universität München, Germany.