1st Edition
Handbook of Low-Level Laser Therapy
Low-Level Laser Therapy (LLLT) also known as photobiomodulation is almost 50 years old, and recently has been getting increasing acceptance from the scientific, medical, and veterinary communities. Discoveries are constantly being made about the cellular and molecular mechanisms of action, the range of diseases that can be treated is also rising, and home use LED devices are becoming common.
This book compiles cutting-edge contributions from the world’s leading experts in Photobiomodulation and LLLT. Chapters cover general concepts, mechanisms of action, in vitro studies, pre-clinical animal studies, veterinary applications and a wide range of clinical topics. Edited by Michael Hamblin from Massachusetts General Hospital and Harvard Medical School, aided by two prominent researchers (Marcelo Sousa and Tanupriya Agrawal), this book will appeal to anyone involved in the basic science, translational aspects and clinical applications of LLLT.
What is Low-Level Laser (Light) Therapy?
Marcelo Victor Pires de Sousa
History of Low-Level Laser (Light) Therapy
Michael R. Hamblin
Lasers, LEDs, and Other Light Sources
James Carroll
Is Coherence Important in Photobiomodulation?
Tomas Hode
Tissue Optics
Bryan James Stephens and Linda Ramball Jones
Light–Tissue Interaction and Light Dosimetry
Ana Carolina de Magalhaes and Elisabeth Mateus Yoshimura
Mitochondrial Light Absorption and Its Effect on ATP Production
Nicolette Houreld
Water as a Photoacceptor, Energy Transducer, and Rechargeable Electrolytic Bio-battery in Photobiomodulation
Luis Santana-Blank, Elizabeth Rodr´ıguez-Santana, Jes ´us A. Santana-Rodr´ıguez, Karin E. Santana-Rodriguez, and Heberto Reyes-Barrios
Role of Reactive Oxygen Species in Low-Level Laser Therapy
Vikrant Rai
Molecular Basis for Photobiomodulation: Light-Induced Nitric Oxide Synthesis by Cytochrome c Oxidase in Low-Level Laser Therapy
Robert Oliver Poyton and Marina Hendrickson
Cytoprotective Effect of Low-Level Light Therapy using LEDs on Neurons
Margaret Wong-Riley and Huan Ling Liang
Low-Level Laser and Cultured Neural Tissue
Patricia J. Armati and Roberta T. Chow
Shining a Light on Parkinson’s Disease
Daniel McKenzie Johnstone, Cecile Moro, Jonathan Stone, Alim-Louis Benabid, and John Mitrofanis
Low-Level Laser Therapy and Stem Cells
Qi Zhang, Chang Zhou, and Tingting Dong
Antimicrobial Photodynamic Therapy
Vanderlei Salvador Bagnato, Cristina Kurachi, Kate Cristina Blanco, and Natalia Mayumi Inada
Low-Level Laser (Light) Therapy forWound Healing in Animal Models
Andre Luiz Oliveira Ramos, Felipe Scholz Ramos, and Marcelo Victor Pires de Sousa
Low-Level Laser Therapy for Arthritis in Animal Models: Beneficial Effect and Action Mechanism
Flavio Aimbire and Paulo de Tarso Camilo de Carvalho
Low-Level Laser Therapy for Lung Diseases: From the Bench to the Bed
Flavio Aimbire
Low-Level Laser (Light) Therapy in Tendon Healing in in Vitro and in Vivo Models
Lucas F. de Freitas and Michael R. Hamblin
Bone Repair in Animal Models
Antonio Luiz B. Pinheiro, Luiz G. Pinheiro Soares, and Aparecida Maria C. Marques
Transcranial Low-Level Laser (Light) Therapy for Stroke and Traumatic Brain Injury in Animal Models
Michael R. Hamblin, Luis De Taboada, and Ying-Ying Huang
Phototherapy in Peripheral Nerve Repair and Muscle Preservation
Shimon Rochkind
Low-Level Laser Therapy for Spinal Cord Repair
Takahiro Ando and Michael R. Hamblin
Low-Level Laser (Light) Therapy for the Treatment of Visual System Injury and Disease
Janis T. Eells, Sandeep Gopalakrishnan, Michele M. Salzman, Krisztina Valter, Jan Provis, Ricardo Natoli, John Mitrofanis, Jonathan Stone, and Melinda Fitzgerald
Protection from Cardiac Ischemia and Reperfusion Injury
Agnes Keszler, Svjetlana Dosenovic, and Martin Bienengraeber
Low-Level Laser and Experimental Aortic Aneurysm: Mechanisms and Therapeutic Implications
Lilach Gavish and S. David Gertz
Low-Level Laser Therapy: A Treatment Modality for Multiple Sclerosis Targeting Autoimmunity and Oxidative Stress
Zenas George, Miguel A. Tolentino, and Jeri-Anne Lyons
Low-Level Laser Therapy as an Alternative Treatment for Snake Envenomation
Camila Squarzoni Dale and Stella Regina Zamuner
Veterinary Low-Level Laser (Light) Therapy Applications for Companion Animals
Richard L. Godine
Emergence of Low-Level Laser (Light) Therapy in Clinical Veterinary Practice
Ronald E. Hirschberg
Photomedicine for Exotic Animals: A Case-Based Discussion
Narda G. Robinson
Recalcitrant Wound: Using Low-Level Laser (Light) Therapy to Manage Non-Healing Wounds and Ulcers
Raymond J. Lanzafame and Istvan Stadler
Clinical Applications with Low-Level Laser Therapy in Arthritis
Jan M. Bjordal
Use of Low-Level Laser Therapy and Light-Emitting Diode Therapy to Improve Muscle Performance and Prevent Damage: From Animal Models to Clinical Trials
Cleber Ferraresi, Nivaldo Parizotto, Vanderlei Bagnato, and Michael R. Hamblin
Low-Level Laser Therapy of Pain: Clinical Applications
Roberta T. Chow
Low-Level Laser Therapy and Its Application in Tinnitus
Alessandra Nara de Souza Rastelli, Emanuelle Teixeira Carrera, Gustavo Nicolodelli, and Michael R. Hamblin
Laser Therapy for the Treatment of Radiculopathy
Jerome M. True and Luis C. Vera
Difficult Path to Treating Acute Ischemic Stroke Patients with Transcranial Near-Infrared Laser Therapy
Paul A. Lapchak, Pramod Butte, and Padmesh S. Rajput
Low-Level Laser (Light) Therapy for Rehabilitation in Traumatic Brain Injury and Stroke, including Chronic Aphasia
Margaret A. Naeser, Paula I. Martin, Michael D. Ho, Maxine H. Krengel, Yelena Bogdanova, Jeffrey A. Knight, Megan K. Yee, Ross Zafonte, Bang-Bon Koo, John G. Roubil, and Michael R. Hamblin
Transcranial Near-Infrared Light for Major Depressive Disorder: Targeting the Brain Metabolism
Paolo Cassano, Abigail R. Archibald, and Dan V. Iosifescu
Low-Level Laser Therapy: A Corner Stone in the Management of Cancer Therapy–Induced Mucositis
Rene-Jean Bensadoun, Idriss Troussier, and Raj G. Nair
Photobiomodulation in Dentistry: Manipulating Biostimulation and Bioinhibition for Clinical Success
Gerry Ross and Alana Ross
Photobiomodulation for the Clinical Treatment of Age-Related Macular Degeneration
Graham Merry and Robert Dotson
Laser (Light) Therapy for Postherpetic Neuralgia
Kevin C. Moore and R. Glen Calderhead
Laser Acupuncture
Lucas F. de Freitas and Michael R. Hamblin
Intravascular Laser Irradiation of Blood
Daiane Thais Meneguzzo, Leila Soares Ferreira, Eduardo Machado de Carvalho, and Cassia Fukuda Nakashima
Nonsurgical Laser Therapy for Type 1 and Type 2 Diabetes
Leonardo Longo
Laser Therapy of Traumatic Central Nervous System Injuries
Leonardo Longo and Diego Longo
Low-Level Laser (Light) Therapy: Aesthetic Applications for Hair
Felipe Scholz Ramos, Andr´e Luiz de Oliveira Ramos, and Marcelo Victor Pires de Sousa
Low-Level Laser (Light) Therapy for Cosmetics and Dermatology
Mossum K. Sawhney and Michael R. Hamblin
Low-Level Laser Therapy for Body Contouring and Fat Reduction
Gaurav K. Gupta
Transcranial Low-Level Laser (Light) Therapy for Neurocognitive Enhancement
Julio C. Rojas and F. Gonzalez-Lima
Post-Operative Uses of Low-Level Laser Therapy
Maria Cristina Chavantes, Nathali Cordeiro Pinto, and Vanessa Milanesi Holanda
Bright New World: Future Directions of Low-Level Laser (Light) Therapy
Marcelo Victor Pires de Sousa and Maria Cristina Chavantes
Biography
Michael R. Hamblin is a principal investigator at the Wellman Center for Photomedicine at Massachusetts General Hospital, Boston, and an associate professor of dermatology at Harvard Medical School and the Harvard-MIT Division of Health Science and Technology. His research interests lie in the areas of photodynamic therapy and low-level light therapy. He has published over 284 peer-reviewed articles and is a fellow of the SPIE.
Marcelo Victor Pires de Sousa holds a bachelor’s degree and a PhD in physics. He is founder and chief science officer of Bright Photomedicine and is involved in the development of new products and dissemination of photomedicine.
Tanupriya Agrawal obtained her MD in 2006 from Netaji Subhash Chandra Bose Government Medical College, Jabalpur, India, followed by a PhD in biomedical sciences from Creighton University, Omaha, Nebraska. She is a visiting postdoctoral fellow at Dr. Hamblin’s lab at the Wellman Center for Photomedicine, Massachusetts General Hospital. She is also an trainee pathology resident at Tufts Medical Center, Boston. Dr. Agrawal has published 11 peer-reviewed articles and 12 conference proceedings, including one oral presentation.
"The book presents exhaustive and timely coverage of low-power laser light therapy and photobiomodulation, a subject gaining increasing acceptance from the scientific and medical communities after years of controversial interpretations of clinical results. The editors have well-coordinated the fifty-four chapters written by experts from universities and hospitals. The book offers a panorama of the many applications reported so far, each of which is referenced within a vast bibliography."
— Optics & Photonics News