1st Edition

Handbook of Natural Toxins, Volume 8 Bacterial Toxins and Virulence Factors in Disease

By Joel Moss Copyright 1995
    656 Pages
    by CRC Press

    656 Pages
    by CRC Press

    This volume describes the structure and function of bacterial toxins and presents a comprehensive review of virulence factors, providing recent information concerning cell physiology and biochemistry, as well as new toxin tools for experimental studies and clinical therapy. A wide variety of toxic proteins, including the toxins that cause diptheria, cholera, pertussis, shigellosis, tetanus, botulism and anthrax, are discussed.;The work is aimed at microbiologists, biochemists, endocrinologists, toxicologists, infectious disease specialists, pathologists, public health officials, and upper-level undergraduate and graduate students in these disciplines.

    Biosynthesis and targeting of pertussis toxin; diphthamide - the toxin target in protein synthesis elogation factor 2; leukocidines; heat-stable enterotoxin of escherichia coli; therapeutic effects of botulinum toxins; endotoxin - a mediator of and potential therapeutic target; zot and ace toxins of vibrio cholerae; ADP-ribosylation factors - a family of guanine nucleotide-binding proteins that activate cholera toxin and regulate vesicular transport; liposomes and vehicles for vaccines; GTP-binding proteins as the substrate of pertussis toxin-catalyzed ADP-ribosylation; modification of actin and rho proteins by clostridial ADP-ribosylating toxins; muramyl peptides as exotoxins - bordetella tracheal cytotoxin; adenylyl cyclase toxin from bordetella pertussis; clostridium difficile and its toxins; structure and function of e. coli heat labile enterotoxin and cholera toxin B-pentamer; anthrax toxins; the diphtheria toxin receptor; bacterial ADP-ribosyltransferases; bordetella pertussis - determinants of virulence; shiga and shiga-like (vero) toxins; cholera toxin and related enterotoxins of gram-negative bacteria.

    Biography

    Joel Moss