Different genetic diagnostic and treatment options are used worldwide to improve routine IVF procedures for the benefit of patients. This handbook updates the new genetic diagnostic technologies that have been translated to practice aiming to improve outcomes in the clinic and have a healthy baby at home. Chapters cover the use of genetic technologies in a personalized manner to unravel the possible genetic risks for the couple wishing to conceive, in terms of sperm, the embryo, the endometrium, miscarriage, and finally the fetus.
Foreword: Views from a Pioneer. Carrier screening for single gene disorder. Meiotic abnormalities in infertile males. Chromosomal analysis of sperm. DNA Fragmentation in sperm: Does it matter? Aneuploidy in human oocytes and preimplantation embryos. Preimplantation genetic diagnosis for aneuploidy: All you need to know. Mitochondria and embryo viability. Preimplantation genetic diagnosis for single gene disorders. Molecular diagnosis of endometrial receptivity. Chromosome abnormalities in human pregnancy wastage: A review of cytogenetic and molecular analyses. Products of conception: Current methodologies and clinical applications. Non-invasive prenatal testing for aneuploidy and beyond. Obstacles to implementing new technology. Dynamics and ethics of reproductive genetics. Index