Handbook of Obesity, Two-Volume Set  book cover
4th Edition

Handbook of Obesity, Two-Volume Set

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ISBN 9781482210675
Published March 10, 2014 by CRC Press
1231 Pages 223 B/W Illustrations

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USD $375.00

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Book Description

This 2 volume set comprises of the 3rd edition of Volume 1 and the 4th edition of Volume 2, both published in 2014.

In recent years, we’ve developed a much better grasp of the biological and other factors associated with the development of obesity. New clinical trials, discoveries related to drug use, and greater understanding of the benefits of weight loss in obese patients have expanded the field of research in this area. Reflecting our evolving understanding of causes and consequences, the two-volume set Handbook of Obesity explores every facet of this disease from cause to cure.

Volume One: Epidemiology, Etiology, and Physiopathology provides comprehensive coverage of the biological, behavioral, and environmental determinants of this critical illness. This new edition is divided into five sections exploring essential factors involved in obesity research:

  • History, Definitions, and Prevalence: Changes over time surrounding our notion of obesity, adiposity traits, and the epidemiology of obesity in various populations
  • Biological Determinants of Obesity: Genetic and epigenetic evidence, fetal life and postnatal influences, the use of animal models in research, endocrine issues, molecular aspects, and issues related to viral infection and adiposity
  • Behavioral Determinants of Obesity: The effects of food and ingestive behavior, smoking, breastfeeding, sleep duration, work/leisure time activity, and sedentary behavior
  • Environmental, Social, and Cultural Determinants of Obesity: The role of agriculture and the food industry, the urban environment, social and economic aspects, cultural factors, environmental pollutants, and economic costs
  • Consequences of Obesity: How excess weight affects and exacerbates a range of comorbid conditions, including diabetes, cardiovascular disease, pulmonary disorders, arthritis, and cancer

Volume Two: Clinical Applications explores essential factors involved in obesity prevention and treatment:

  • Prevention of Obesity: Strategies such as reengineering the environment to encourage physical activity and prevent excessive weight gain in children and adults

  • Evaluation of the Overweight or Obese Patient: Methods for assessing the overweight individual and the role of the primary care physician in patient management

  • Medical Treatment of Obesity and Weight Management Issues in the Treatment of Obesity: Lifestyle for weight loss and weight maintenance, diet and exercise, medications, herbal agents, and issues related to childhood obesity

  • Surgery: Screening for bariatric surgery, laparoscopic banding, liposuction, and other surgical techniques and strategies for operative and postoperative care

  • Epilogue: The economic assessment and cost-effectiveness of treatments for obesity, how obesity is viewed internationally, and governmental responses to challenges arising from the growing prevalence of obesity

Presenting the insight of international experts and edited by two eminent leaders in obesity research, this two-volume set is essential for health care providers in search of a comprehensive and up-to-date guide to diagnosing and treating obese patients.


Table of Contents


History, Definitions, and Prevalence

Obesity Has Always Been with Us: An Historical Introduction; George A. Bray

Measurement of Total Adiposity, Regional Fat Depots, and Ectopic Fat; Steven B. Heymsfield, Houchun Harry Hu, ZiMian Wang, Wei Shen, and Ye Jin

Anthropometric Indicators in Relation to the Gold Standards; Peter T. Katzmarzyk

Worldwide Prevalence of Obesity in Adults; Jacob C. Seidell

Prevalence and Consequences of Pediatric Obesity; Nazrat M. Mirza and Jack A. Yanovski

Obesity in Older Adults in the United States; Tala H.I. Fakhouri, Brian K. Kit, Margaret D. Carroll, Katherine M. Flegal, and Cynthia L. Ogden

Gender, Ethnic, and Geographic Variation in Adiposity; Timothy Olds and Carol Maher

Biological Determinants of Obesity

Genetic Component to Obesity: Evidence from Genetic Epidemiology; Louis Pérusse, Treva K. Rice, and Claude Bouchard

Genes and the Predisposition to Obesity; Marcel den Hoed and Ruth J. F. Loos

Epigenetic Mechanisms in Obesity; Robert A. Waterland

Fetal and Early Postnatal Life Determinants of Adiposity; Felicia M. Low, Peter D. Gluckman, and Mark A. Hanson

Animal Models of Obesity: Perspectives on Evolution of Strategies for Their Development and Analysis of Their Phenotypes; Heike Münzberg, Tara M. Henagan, and Thomas W. Gettys

Animal Models of Obesity: Nonhuman Primates; Barbara C. Hansen

CNS Regulation of Energy Balance; Hans-Rudolf Berthoud and Barry E. Levin

Gastrointestinal Regulation of Energy Balance; Timo D. Müller, Kristy Heppner, Chun-Xia Yi, Paul T. Pfluger, and Matthias H. Tschöp

Gut Microbiome and Obesity; Patrice D. Cani

Sympathetic Nervous System and Endocrine Determinants of Energy Balance; Hamid R. Farshchi and Ian A. Macdonald

Insulin Resistance and Obesity; Charmaine S. Tam, Morvarid Kabir, Richard N. Bergman, and Eric Ravussin

White and Brown Adipose Tissue Development; Meghan E. McDonald and Stephen R. Farmer

Adipose Tissue Metabolism, Adipokines, and Obesity; Dominique Langin and Max Lafontan

Visceral Adipose Tissue and Ectopic Fat Deposition; Amalia Gastaldelli

Skeletal Muscle Metabolism and Obesity; Jeffrey J. Brault, G. Lynis Dohm, and Joseph A. Houmard

Mitochondrial Bioenergetic Aspects of Obesity and Weight Loss; Mary-Ellen Harper, Robert Dent, and Ruth McPherson

Resting Metabolic Rate, Thermic Effect of Food, and Obesity; Yves Schutz and Abdul G. Dulloo

Energy Cost of Exercise, Postexercise Metabolic Rates, and Obesity; Einat Shalev-Goldman, Trevor O’Neill, and Robert Ross

Energy Partitioning, Substrate Oxidation Rates, and Obesity; Angelo Tremblay, Yves Deshaies, and Katherine Cianflone

Viral Infections and Adiposity; Nikhil V. Dhurandhar, Emily J. Dhurandhar, and Richard L. Atkinson

Behavioral Determinants of Obesity

Obesity: Influence of the Food Environment on Ingestive Behaviors; Richard D. Mattes and Sze Yen Tan

Obesity and Related Eating Disorders; Brooke A. Bailer, Lauren E. Bradley, and Kelly C. Allison

Tobacco Use, Smoking Cessation, and Obesity; Carole Clair, Semira Gonseth, Jacques Cornuz, and Ivan Berlin

Breastfeeding and Later Obesity; Nancy F. Butte

Beverages and Obesity: Biology, History, Trends; Barry M. Popkin and Frank B. Hu

Sedentary Time and Obesity; Neville Owen and Marc Hamilton

Occupational Work and Obesity; Nicholas D. Gilson and Catrine Tudor-Locke

Leisure-Time Physical Activity and Obesity; Thrudur Gunnarsdottir, Renee J. Rogers, John M. Jakicic, and James O. Hill

Sustained Short Sleep and Risk of Obesity: Evidence in Children and Adults; Michelle A. Miller, George Smith, Andrew O’Keeffe, and Francesco P. Cappuccio

Environmental, Social, and Cultural Determinants of Obesity

Role of Agriculture and the Food Industry in America’s Obesity; James E. Tillotson

Transportation Policies and Obesity; David R. Bassett Jr.

Urban Environment, Building Design, and Obesity; Reid Ewing and Gail Meakins

Social and Economic Determinants of Obesity; Lindsay McLaren

Influence of Culture on Obesity; Alison Tovar and Aviva Must

Bias, Discrimination, and Obesity; Rebecca M. Puhl, Kelly D. Brownell, and Jenny A. DePierre Environmental Chemicals and Obesity; Amanda S. Janesick, Thaddeus T. Schug, Jerrold J. Heindel, and Bruce Blumberg

Economic Costs of Obesity; Ping Zhang, Sundar S. Shrestha, and Rui Li

Consequences of Obesity

Obesity and Mortality Rates; Gary Whitlock and Rachel R. Huxley

Obesity and Heart Disease; Peter W.F. Wilson

Obesity and Hypertension; Raj S. Padwal and Arya M. Sharma

Obesity and Lipoprotein Metabolism; Sally Chiu and Ronald M. Krauss

Obesity and Type Diabetes; Henna Cederberg and Markku Laakso

Obesity and Metabolic Syndrome; Jean-Pierre Després

Obesity and Cancer: Clinical Epidemiology; Andrew G. Renehan

Inflammatory Causes of Obesity and Metabolic Diseases; Ebru Erbay and Gökhan S. Hotamıs¸lıgil

Obesity and Gallbladder Disease; Cynthia W. Ko and Sum P. Lee

Obesity and Liver: Cell Death, Compensatory Growth, and Repair of Damage; Giovanni Tarantino

Obesity, Lung Function, and Lung Disease; Nour A. Assad, Jesse H. Alvarado, and Akshay Sood

Obesity, Arthritis, and Gout; Luke Dawson, Anita E. Wluka, Yuanyuan Wang, and Flavia M. Cicuttini

Obesity and Mental Health; Lucy F. Faulconbridge and Anthony Fabricatore

Obesity and Health-Related Quality of Life; Donald A. Williamson and W. Jack Rejeski

Obesity and Pregnancy Outcomes; Raul Artal and Sarah Hopkins

Obesity, an Inactive Lifestyle and Low Fitness: The Most Unhealthy Combination; Paul A. McAuley and Steven N. Blair




Prevention of Obesity

Dietary Changes in Human Evolution: Implications for Prevention of Obesity; Staffan Lindeberg and S. Boyd Eaton

Prevention in Adults; Garry Egger and Boyd Swinburn

Prevention of Obesity in Childhood and Adolescence; Tim Lobstein

Reengineering the Built Environment: Progress in Schools, Work Sites, Neighborhoods, and Parks; Deborah Cohen

Obesity and Evolution: Implications for Prevention of Type 2 Diabetes; S. Boyd Eaton and Staffan Lindeberg

Evaluation of the Overweight or Obese Patient

Classification and Evaluation of the Overweight Patient; Robert F. Kushner and George A. Bray

Waist Girth: A Critical Evaluation of Usefulness; Soo Lim, Marie-France Hivert, and James B. Meigs

Genetic Evaluation of Patients with Syndromic and Nonsyndromic Obesity; Ismaa Sadaf Farooqi and Stephen O’Rahilly

Impact of Voluntary Weight Loss on Morbidity and Mortality; Edward W. Gregg

Obesity and the Primary Care Physician; Ken Fujioka and Tanja Crockett

Medical Treatment of Obesity and Weight Management Issues in the Treatment of Obesity: Behavior, Diet, Exercise and Medications

Behavioral Approaches to the Treatment of Obesity; Rena R. Wing

Preventing Weight Regain after Weight Loss; Stephen D. Anton, John P. Foreyt, and Michael G. Perri

Strategies to Reduce Calories in Food; Alexandra G. Kazaks and Judith S. Stern

Diet Composition and Weight Loss; Angela Makris, Michelle R. Lent, and Gary D. Foster

Dietary Protein and Weight Management; Margriet S. Westerterp-Plantenga

Exercise and Weight Management; Tim Church

Drugs That Cause Weight Gain and Clinical Alternatives to Their Use; Albert Hsieh, Arianne Sweeting, Avinash Suryawanshi, and Ian D. Caterson

Sibutramine, Phentermine, and Diethylpropion: Sympathomimetic Drugs in the Management of Obesity; Donna H. Ryan and George A. Bray

Drugs That Modify Fat Absorption and Alter Metabolism; George A. Bray and Donna H. Ryan

Serotonin Receptor Modulation in the Treatment of Obesity; Steven R. Smith

Combination Therapy: Topiramate and Phentermine; Kishore M. Gadde

Combination Therapy: Bupropion plus Naltrexone (Contrave); Donna H. Ryan and George A. Bray

Glucagon-Like Peptide- Agonists and Weight Regulation; Niels Vrang and Arne Astrup

Brown Adipose Tissue as a Target; Barbara Cannon and Jan Nedergaard

Herbal and Alternative Approaches to Obesity; Frank L. Greenway and David Heber

Is There a Future for Gene Therapy in Obesity? Sergei Zolotukhin

Special Issues in Treatment of Pediatric Obesity; Matthew A. Haemer and Stephen R. Daniels

Prevention and Management of Dyslipidemia, Hyperglycemia, and the Metabolic Syndrome in Obese Patients; Annie Ferland and Robert H. Eckel


Surgical Procedures in the Treatment of Obesity and Its Comorbidities; Ali Aminian and Philip R. Schauer

Swedish Obese Subjects, SOS; Lars Sjöström

Laparoscopic Adjustable Gastric Banding; Paul E. O’Brien

Evolving Surgical Therapy for Obesity; Susan C. Clark and Walter J. Pories

Liposuction and Obesity; Gemma Fraterrigo, Luigi Fontana, and Samuel Klein

Mechanisms Underlying the Endocrine Management of Postbariatric Surgical Patients; David Heber and Frank L. Greenway


Cost-Effectiveness of Obesity Prevention and Treatment; Amy E. Rothberg, Anna Peeters, and William H. Herman

Government’s Evolving Role: Nutrition, Education, Regulation, Monitoring, and Research; W. Philip T. James and João Breda


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"This two-volume set of books is the most comprehensive encyclopaedia of obesity that I have read … Name any aspect of obesity and this book has it covered! Reading it from beginning to end is a pleasurable education, whilst digital access via VitalBook (eBook) on your VitalSource Bookshelf (included in the price) will enable immediate offline access in the clinic or seminar…The book is the product of a huge international college of contributors whose presentations are ably and intuitively orchestrated by the editors. As a comprehensive treatise on all aspects of obesity I cannot recommend it enough."
—Jim Young, Editor-in-Chief, Glycosmedia

"As an obesity specialist, I plan on giving this a thorough reading and recommending it to colleagues …The book covers prevention of obesity, initial evaluation of the overweight/obese patient (including methods for doing so), medical and surgical options, including lifestyle modifications, and finally the health services/healthcare systems implications of obesity. It is a thorough, up-to-date, and detailed book."’
—Meltem Zeytinoglu, MD, MBA, University of Chicago Medical Center for Doody's Review Service

"Both these well-documented and well-researched volumes reflect the most current trends in obesity studies internationally … [they are] highly recommended for academic and medical libraries, even for those that already own a copy of earlier editions."