1st Edition

Handbook of PAF and PAF Antagonists

Edited By

lPierre Braquet

ISBN 9780367217655
Published December 12, 2020 by CRC Press
282 Pages

USD $65.00

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Book Description

Published in 1991: Since its characterization in the 1970s from antigen-stimulated rabbit basophils, platelet-activating factor (PAF) has been demonstrated to be produced by, and act upon, a variety of cell types. PAF antagonists, which have been obtained from both natural sources and chemical synthesis, now represent a new class of therapeutic agents and may provide new prospects for treating several major pathologies, particularly shock, ischemia and asthma. This book provides a unique overview of the chemistry, molecular modeling, pharmacology, and clinical potential of the major classes of natural and synthetic PAF antagonists. Compounds reviewed include the ginkgolides, diketopiperazines, neolignans, hetrazepines, cyclic and 1,3-dioxolan derived PAF analogs, pyrrolo[1,2-c]thiazoles, imidazo[2,1-a]isoquinolines and pyridoquinazoline carboxamides. Consisting of 12 chapters written by leading experts in PAF antagonist research, this book is essential reading for students, researchers, clinicians, and medical practitioners involved in this rapidly developing field of biomedical research.

Table of Contents

Part 1: Natural PAF Antagonists

1. Recent Progress in PAF Antagonist Research

Matyas Koltai

2. PAF Antagonists From Microbial Origin: Structure-Activity Relationship of Diketopiperazine Derivatives

Keiji Hemmi

3. Kadsurenone Type Neolignans, Potential PAF Antagonists: Chemistry and Distribution

Otto R. Gottlieb

Part 2: Synthetic PAF Antagonists

4. Structure Activity Relationships CV-3988 and CV-6209 PAF Antagonists Series

Muneo Takatani

5. Aminoacylates and Aminocarbamates of 2-Substituted 4-Hydroxymethyl 1,3-Dioxolans: Structure Activity Relationships and Biological Activity as PAF-Antagonists

Colette Broquet

6. GS 1065-180 and Related PAF Antagonists: Chemistry and Pharmacology

Gunnar Grue-Serensen

7. Structure Activity Relationships in Cyclic Analogs of PAF with PAF Antagonist Properties

William J. Houlihan

8. Pharmacology of Hetrazepines as PAF-Antagonists

Hubert O. Heuer

9. Structure-Activity Relationships in Pyrrolo [1,2-c] Thiazoles PAF Receptor

Daniel Lave

10. Structure Activity Relationships in 5-Aryl-2,3-Dihydroimidazo[2,la]Isoquinoline PAF Antagonists

William J. Houlihan

11. N-[w-(Heteroaryl)Alkyl]Carboxamide Derivatives as Platelet Activating Factor Antagonists: Structure-Activity Relationships and Biological Data

Jefferson W. Tilley

Part 3: Molecular Modeling

12. Structure Activities in PAF Acether Antagonist Series Using Molecular Lipophilic Potential Studies

J. P. Dubost



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Pierre Braquet Ph.D., D.Sc. is Director and General Manager of the Ipsen‐Beaufour pharmaceutical group at the Institut Henri Beaufour, Le Plessis Robinson, France and Professor at Louisiana State University, New Orleans, Louisiana.