Handbook of Pharmaceutical Granulation Technology: 3rd Edition (Hardback) book cover

Handbook of Pharmaceutical Granulation Technology

3rd Edition

Edited by Dilip M. Parikh

CRC Press

676 pages | 300 B/W Illus.

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Hardback: 9781439807897
pub: 2009-11-24
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Description

The Third Edition presents all pharmaceutical industry personnel and those in academia with critical updates on the recent advances in granulation technology and changes in FDA regulatory guidelines. Addressing precisely how these recent innovations and revisions affect unit operation of particle generation and granulation, this text assists the reader in selecting the ideal technology for his/her company’s particular drug delivery system. This knowledge helps ensure that regulatory guidelines are followed and met in a cost-effective manner.

Here are just a few of the new topics discussed in this revised and expanded handbook:

  • spray drying
  • nanotechnology
  • biotechnologically derived drugs
  • nutraceuticals
  • controlled release drugs
  • particle engineering
  • supercritical fluids
  • concepts of design space
  • process optimization
  • regulation harmonization by global health authorities
  • process controlexpert systems
  • Process Analytical Technology (PAT)
  • regulatory issues in granulation

In addition, all chapters in the Handbook of Pharmaceutical Granulation Technology explore the fundamentals of powder characterization, granulation, and state-of-the-art technologies, modeling, application of expert systems, and manufacturing optimization.

Reviews

"…comprehensive….

"… very useful for pharmaceutical professionals."

-IASI Polytechnic Magazine (for previous edition)

Table of Contents

Preface

Contributors

Introduction, Dilip M. Parikh

Theory of Granulation: An Engineering Perspective, Bryan J. Ennis

PARTICLE FORMATION

Drug Substance and Excipient Characterization, Lai Wah Chan, Xiang Kou, and Paul W. S. Heng

Binders in Pharmaceutical Granulation, Thomas Dürig

Spray Drying and Pharmaceutical Applications, Metin Çelik and Susan C. Wendell

Supercritical Fluid Technology, Martin A. Wahl

Pharmaceutical Applications of Nanoengineering, Deepak Thassu, Yashwant Pathak, and Michel Deleers

GRANULATION PROCESSES

Roller Compaction Technology, Ronald W. Miller

Wet Granulation in Low- and High-Shear Mixers, Rajeev Gokhale and Namrata R. Trivedi

Batch Fluid Bed Granulation, Dilip M. Parikh and David M. Jones

Single-Pot Processing, Harald Stahl and Griet Van Vaerenbergh

Extrusion-Spheronization as a Granulation Technique, David F. Erkoboni

Continuous Granulation, Chris Vervaet and Jean Paul Remon

PRODUCT ORIENTED GRANULATIONS

Effervescent Granulation, Guia Bertuzzi

Granulation Approaches in Biotech Industry, Tuo Jin, Weien Yuan, and Hui Li

Granulation of Plant Products and Nutraceuticals, Dilip M. Parikh

Granulation Approaches for Modified Release Products, Neelima Phadnis and Sree Nadkarni

Granulation of Poorly Water-Soluble Drugs, Albert W. Brzeczko, Firas El Saleh, and Jiao Yang

Granulation Approaches for Orally Disintegrating Formulations, Gopi Venkatesh

Melt Granulation, Chris Vervaet and Jean Paul Remon

CHARACTERIZATION AND SCALE-UP

Sizing of Granulation, Gurvinder Singh Rekhi and Richard Sidwell

Granulation Characterization, Cecil W. Propst

Bioavailability and Granule Properties, Sunil S. Jambhekar

Granulation Process Modeling, Ian T. Cameron and Fu Y. Wang

Scale-Up Considerations in Granulation, Yinghe He, Lian X. Liu, James D. Litster, and Defne Kayrak-Talay

Advances in Process Controls and End-Point Determination, Kevin A. Macias and M. Teresa Carvajal

OPTIMIZATION STRATEGIES, TOOLS AND REGULATORY CONSIDERATIONS

Expert Systems and Their Use in Pharmaceutical Applications, Metin Çelik and Susan C. Wendell

Regulatory Issues in Granulation: The Pharmaceutical Quality for the 21st Century—A Risk-Based Approach, Prasad Kanneganti

Quality by Design and Process Analytical Technology in Granulation, Gopi Vudathala, Stanley Rodgers, and John E. Simmons

Index

About the Series

Drugs and the Pharmaceutical Sciences

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED017000
MEDICAL / Dermatology
MED071000
MEDICAL / Pharmacology