Handbook of Photomedicine: 1st Edition (Hardback) book cover

Handbook of Photomedicine

1st Edition

Edited by Michael R. Hamblin, Yingying Huang

CRC Press

886 pages | 18 Color Illus. | 375 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9781439884690
pub: 2013-10-22
SAVE ~$50.00
eBook (VitalSource) : 9780429193842
pub: 2013-10-22
from $28.98

FREE Standard Shipping!


Providing the most comprehensive, up-to-date coverage of this exciting biomedical field, Handbook of Photomedicine gathers together a large team of international experts to give you a complete account of the application of light in healthcare and medical science. The book progresses logically from the history and fundamentals of photomedicine to diverse therapeutic applications of light, known collectively as phototherapies. It facilitates your understanding of human diseases caused by light, the rationale for photoprotection, and major applications of phototherapy in clinical practice.

The handbook begins with a series of historical vignettes of pioneers from the last two centuries. It also presents the fundamentals of physics and biology as applied to photomedicine. It next examines conditions and diseases caused by light, including skin cancer, dermatoses, and immunosuppression.

The remainder of the book focuses on the most important clinical therapeutic applications of different kinds of light that vary in both wavelength and intensity. The book discusses ultraviolet phototherapy for skin diseases and infections and presents the basic science of photodynamic therapy and its use in cancer therapy and other medical specialties. It then covers mechanistic studies and clinical applications of low-level laser (light) therapy as well as the use of high power or surgical laser therapy in specialties, such as dentistry and dermatology. The book concludes with a collection of miscellaneous types of phototherapy.

Table of Contents

History and Fundamentals

Introduction: Historical Vignettes from the Field of Photomedicine

Michael R. Hamblin and Ying-Ying Huang

History and Fundamentals of Lasers and Light Sources in Photomedicine

Edward Victor Ross and Lee Miller

Light-Tissue Interactions

Pradeep K. Gupta, Mahesh K. Swami, and Harishankar Patel

History and Fundamentals of Photodynamic Therapy (PDT)

Tyler G. St. Denis and Michael R. Hamblin

History and Fundamentals of Low-Level Light Therapy (LLLT)

Asheesh Gupta and Michael R. Hamblin

Diseases Caused by Light

Ultraviolet (UV) Effects on Skin

Kris Nys and Patrizia Agostinis

Photocarcinogenesis Nonmelanoma Skin Cancer

Gary M. Halliday, Scott N. Byrne, J. Guy Lyons, and Diona L. Damian

Autoimmune Photodermatoses

John L.M. Hawk

Photoaggravated Dermatoses

PierGiacomo Calzavara-Pinton and Raffaella Sala


Rui Yin and Michael R. Hamblin

UV Radiation (UVR)-Induced Immunosuppression

Mary Norval and Prue H. Hart

The Porphyrias

Eric Gou and Karl E. Anderson


Chanisada Wongpraparut and Henry W. Lim

Botanical Antioxidants for Photochemoprevention

Eiman Mukhtar, Vaqar Adhami, and Hasan Mukhtar

Reversal of DNA Damage in the Skin with DNA Repair Liposomes

Peter Wolf

Climate Change and UVR Exposure

Mohammad Ilyas

Photochemistry and Photobiology of Vitamin D

Michael F. Holick

Ultraviolet Phototherapy

UVB Phototherapy for Psoriasis

Edidiong Ntuen Kaminska, Piergiacomo Calzavara-Pinton, and Bernhard Ortel

PUVA Therapy

Juliana Basko-Plluska, Herbert Hönigsmann, and Bernhard Ortel

Extracorporeal Photopheresis

Fiona Dignan and Julia Scarisbrick

UVC Therapy for Infections

Tianhong Dai and Michael R. Hamblin

Photodynamic Therapy

Recent Advances in Developing Improved Agents for PDT

Penny Joshi, Courtney Saenz, Joseph R. Missert, and Ravindra K. Pandey

5-Aminolevulinic Acid and Its Derivatives

Asta Juzeniene and Patrycja Mikolajewska

Gentically Encoded Photosensitizers: Structure, Photosensitization Mechanisms, and Potential Application to Photodynamic Therapy

Cristina Flors and Santi Nonell

Light Dosimetry for PDT: Basic Concepts

Henricus J.C.M. Sterenborg, Robert L.P. van Veen, Jan-Bonne Aans, Arjen Amelink, and Dominic J. Robinson

Multimodality Dosimetry

Jarod Finlay

Cell Death and PDT-Based Photooxidative (Phox)-Stress

Abhishek D. Garg and Patrizia Agostinis

Vascular and Cellular Targeted PDT

Shannon M. Gallagher-Colombo and Theresa M. Busch

PDT for Increased Delivery of Anticancer Drugs

Elodie Debefve, Yabo Wang, Thorsten Krueger, and Hubert van den Bergh

Targeting Strategies in Photodynamic Therapy for Cancer Treatment

Marlène Pernot, Céline Frochot, Régis Vanderesse, and Muriel Barberi-Heyob

Enhancing PDT of Cancer with Mechanism-Based Combination Strategies

Lei Zak Zheng, R. Bryan Sears, Iqbal Massodi, Stanley Kimani, and Tayyaba Hasan

Nanoparticles for PDT

Girgis Obaid and David A. Russell

Drug Delivery Systems for PDT

Ryan F. Donnelly

Antimicrobial PDT for Clinical Infectious Diseases

Anja Eichner, Fernanda Pereira Gonzales, and Tim Maisch

PDT and the Immune System

Fatma Vatansever and Michael R. Hamblin

Detection of Bladder Cancer by Fluorescence Cystoscopy: From Bench to Bedside—the Hexvix Story

Georges Wagnières, Patrice Jichlinski, Norbert Lange, Pavel Kucera, and Hubert van den Bergh

Photochemical Internalization: From Bench to Bedside with a Novel Technology for Targeted Macromolecule Therapy

Kristian Berg, Anette Weyergang, Anders Høgset, and Pål K. Selbo

The Story of TOOKAD: From Bench to Bedside

Avigdor Scherz and Yoram Salomon

PDT in Ophthalmology

Patrycja Nowak-Sliwinska, Andrea Weiss, Michel Sickenberg, and Hubert van den Bergh

PDT in Dermatology

Alexis Sidoroff

PDT in the Gastrointestinal Tract

Drew Schembre

Photodynamic Applications in Brain Tumors

Sam Eljamel

PDT for Malignant Pleural Disease

Charles B. Simone, Melissa Culligan, Joseph S. Friedberg, and Keith A. Cengel

Clinical PDT in the Chinese Region

Yih-Chih Hsu and Zheng Huang

PDT and Fluorescent Diagnostics in the Russian Federation

Elena G. Vakulovskaya

Low-Level Light Therapy

Chromophores (Photoacceptors) for LLLT

Tiina I. Karu

LLLT Signaling Pathways

Da Xing and Shengnan Wu

Irradiation Parameters, Dose Response, and Devices

James D Carroll

LLLT: Clearly a New Paradigm in the Management of Cancer Therapy-Induced Mucositis

Rene-Jean Bensadoun

LLLT for Wound Healing

Lilach Gavish

LLLT in the Treatment of Pain

Roberta Chow

LLLT in Arthritis and Tendinopathies

Jan Magnus Bjordal and Rodrigo A.B. Lopes-Martins

LLLT and Light-Emitting Diode Therapy on Muscle Tissue: Performance, Fatigue, and Repair

Cleber Ferraresi and Nivaldo A. Parizotto

LLLT for Stroke and Brain Disease

Takahiro Ando, Ying-Ying Huang, and Michael R Hamblin

LLLT for Nerve and Spinal Cord Regeneration

Nivaldo A. Parizotto

LLLT in Dentistry

Daiane Thais Meneguzzo and Leila Soares Ferreira

LLLT and Stem Cells

Heidi Abrahamse

LLLT for Cosmetics and Dermatology

Pinar Avci, Theodore Nyame, and Michael R. Hamblin

Surgical Laser Therapy

Lasers and Intense Pulsed Light Treatment of Skin

Rui Yin, Garuna Kositratna, and Rox R Anderson

Therapeutic Uses of Lasers in Eye Care

Charles Wormington

Lasers Used in Dentistry

Kirpa Johar and Vida de Arce

Lasers in Urology

Naeem Bhojani and James Lingeman

Lasers in Otolaryngology

James A. Burns and Anca M. Barbu

Laser Targeting to Nanoparticles for Theranostic Applications

James Ramos, Huang-Chiao Huang, and Kaushal Rege

Laser Immunotherapy

Tomas Hode, Xiaosong Li, Mark Naylor, Lars Hode, Peter Jenkins, Gabriela Ferrel, Robert E. Nordquist, Orn Adalsteinsson, John Lunn, Michael R. Hamblin, Luciano Alleruzzo, and Wei R. Chen

Tissue Repair by Photochemical Cross-Llinking

Irene E. Kochevar and Robert W. Redmond

Other Phototherapy and Future Outlook

Optical Guidance for Cancer Interventions

Brian C. Wilson and Robert Weersink

Phototherapy for Newborn Jaundice

Michael Andrew Choma

Biological Evidence of the Efficacy of Light Therapy in Psychiatric Disorders

Anne-Marie Gagné and Marc Hebert

Future Developments in Photomedicine and Photodynamic Therapy

Thierry J. Patrice

About the Editors

Michael R. Hamblin, PhD, is a principal investigator in the Wellman Center for Photomedicine at Massachusetts General Hospital, an associate professor of dermatology at Harvard Medical School, and a member of the affiliated faculty of the Harvard-MIT Division of Health Science and Technology. A SPIE Fellow, he is an associate editor for seven journals, serves on the NIH Study Sections, and holds eight patents. Dr. Hamblin has published over 190 peer-reviewed articles, over 150 conference proceedings, and numerous book chapters. His research in photomedicine concentrates on photodynamic therapy for infections, cancer, and heart disease as well as low-level light therapy for wound healing, arthritis, traumatic brain injury, and hair regrowth. Ying-Ying Huang, MD, is an instructor at Harvard Medical School. Dr. Huang has published 40 peer-reviewed articles, 15 conference proceedings, and several book chapters. Her research focuses on photodynamic therapy for infections and cancer as well as the mechanisms of low-level light therapy.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Dermatology
SCIENCE / Physics