446 pages | 54 B/W Illus.
Preformulation studies are the physical, chemical, and biological studies needed to characterize a drug substance for enabling the proper design of a drug product, whereas the effectiveness of a drug product is determined during the formulation studies phase. Though the two disciplines overlap in practice, each is a significantly distinct phase of new drug development. Entirely focused on preformulation principles, this handbook provides detailed descriptions of preformulation methodologies, gives a state-of-the-art description of each technique, and lists the currently available tools useful in providing a comprehensive characterization of a new drug entity.
Drug Discovery Trends o Intellectual Property Considerations o The Scope of Preformulation Studies o Dissociation, Partitioning and Solubility o Release, Dissolution and Permeation o Solid State Properties o Dosage Form Consideration in Preformulation o Chemical Drug Substance Characterization o Characterization of Biopharmaceutical Drugs o Characterization of Phytomedicines