Handbook of Radiotherapy Physics: Theory and Practice, Second Edition, Two Volume Set, 2nd Edition (Hardback) book cover

Handbook of Radiotherapy Physics

Theory and Practice, Second Edition, Two Volume Set, 2nd Edition

Edited by Philip Mayles, Alan E. Nahum, J.C. Rosenwald

CRC Press

2,424 pages | 757 B/W Illus.

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Hardback: 9780367192075
pub: 2019-08-28
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From the essential background physics and radiobiology to the latest imaging and treatment modalities, the updated second edition of Handbook of Radiotherapy Physics: Theory and Practice covers all aspects of the subject.

In Volume I, Part A includes the Interaction of Radiation with Matter – charged particles and photons - and the Fundamentals of Dosimetry – with an extensive section on small-field physics. Part B covers Radiobiology with increased emphasis on hypofractionation. Part C describes Equipment for Imaging and Therapy including MR-guided linear accelerators. Part D on Dose Measurement includes chapters on ionisation chambers, solid-state detectors, film and gels, as well as a detailed description and explanation of Codes of Practice for Reference Dose Determination including detector correction factors in small fields. Part E describes the properties of Clinical (external) Beams. The various methods (or ‘algorithms’) for Computing Doses in Patients irradiated by photon, electron and proton beams are described in Part F with increased emphasis on Monte-Carlo-based and grid-based deterministic algorithms.

In Volume 2, Part G covers all aspects of Treatment Planning including CT-, MR- and Radionuclide-based patient imaging, Intensity-Modulated Photon beams, Electron and Proton Beams, Stereotactic and Total Body Irradiation and the use of the dosimetric and radiobiological metrics TCP and NTCP for plan evaluation and optimisation. Quality Assurance fundamentals with application to equipment and processes is covered in Part H. Radionuclides, equipment and methods for Brachytherapy and Targeted Molecular Therapy are covered in Parts I and J respectively. Finally, Part K is devoted to Radiation Protection of the public, staff and patients. Extensive tables of Physical Constants, Photon, Electron and Proton Interaction data, andtypical Photon Beam and Radionuclide data are given in Part L.

Edited by recognised authorities in the field, with the individual chapters written by renowned specialists, this second edition ofHandbook of Radiotherapy Physics provides the essential up-to-date theoretical and practical knowledge to deliver safe and effective radiotherapy. It will be of interest to clinical and research medical physicists, radiation oncologists, radiation technologists, PhD and Masters students.

Table of Contents


Interaction of Charged Particles with Matter

Interactions of Photons with Matter

The Monte Carlo Simulation of Radiation Transport

Principles and Basic Concepts in Radiation Dosimetry


Radiobiology of Tumors

Radiobiology of Normal Tissues

Dose Fractionation in Radiotherapy


Kilovoltage X-Ray Units

Linear Accelerators

Cobalt Machines


Portal Imaging Devices


Ionisation Chambers

Radiothermoluminescent Dosimeters and Diodes

Radiation Sensitive Films and Gels

Absolute Dose Determination under Reference Conditions

Relative Dose Measurements and Commissioning


From Measurements to Calculations

Kilovoltage X-Rays

Megavoltage Photon Beams

Manual Dose Calculations in Photon Beams

Electron Beams


Principles of Patient Dose Computation

Patient Dose Computation for Photon Beams

Patient Dose Computation for Electron Beams

Monte-Carlo Based Patient Dose Computation


Target Definition

Patient Data Acquisition

Magnetic Resonance (MR) Imaging in Treatment Planning

Beam Definition - Virtual Simulation

Photon-Beam Treatment Planning Techniques

Electron-Beam Treatment Planning Techniques

Dose Evaluation of Treatment Plans

Biological Evaluation of Treatment Plans


Rationale and Management of the Quality System

Quality Control of Megavoltage Equipment

Quality Assurance of the Treatment Planning Process

Quality Control of Treatment Delivery

Recording and Verification - Networking

Data Communication with DICOM


Conformal and Intensity-Modulated Radiation Therapy

Intensity-Modulation Therapy: Practical Aspects

Stereotactic Techniques

Proton Beams in Radiotherapy

Total Body Irradiation (TBI)

Total Skin Electron Irradiation

High LET Modalities


Clinical Introduction to Brachytherapy

Calibration and Quality Assurance of Brachytherapy Sources

Afterloading Equipment for Brachytherapy

Dose Calculation for Brachytherapy Sources

Brachytherapy Treatment Planning

Radiobiology of Brachytherapy


Dosimetry of Unsealed Sources

Radionuclide Selection for Unsealed Source Therapy

Radiopharmaceutical Targeting for Unsealed Source Therapy


Theoretical Background to Radiation Protection

Radiation Protection Regulation

Practical Radiation Protection in Radiotherapy

Radiation Protection Regulation in the United Kingdom


About the Editors

Philip Mayles, Clatterbridge Centre for Oncology, UK.

Alan Nahum, formerly of the Clatterbridge Centre for Oncology, UK.

Jean Claude Rosenwald, Institute Curie, Paris, France.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
MEDICAL / Radiology & Nuclear Medicine
SCIENCE / Physics
SCIENCE / Radiation
SCIENCE / Radiology