Handbook of Radiotherapy Physics: Theory and Practice, 1st Edition (Hardback) book cover

Handbook of Radiotherapy Physics

Theory and Practice, 1st Edition

Edited by P Mayles, A Nahum, J.C Rosenwald

CRC Press

1,450 pages | 539 B/W Illus.

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Hardback: 9780750308601
pub: 2007-06-12
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From background physics and biological models to the latest imaging and treatment modalities, the Handbook of Radiotherapy Physics: Theory and Practice covers all theoretical and practical aspects of radiotherapy physics.

In this comprehensive reference, each part focuses on a major area of radiotherapy, beginning with an introduction by the editors and then subdividing into self-contained chapters. The first three parts present the fundamentals of the underlying physics, radiobiology, and technology involved. The ensuing sections discuss the support requirements of external beam radiotherapy, such as dose measurements, properties of clinical beams, patient dose computation, treatment planning, and quality assurance, followed by a part that explores exciting new advances that include developments in photon and particle therapy. Subsequent sections examine brachytherapy using sealed and unsealed sources and provide the framework of radiation protection, including an appendix that describes the detailed application of UK legislation. The final part contains handy tables of both physical constants and attenuation data.

To achieve safe and effective radiotherapy, there needs to be a close understanding among various disciplines. With contributions from renowned specialists, the Handbook of Radiotherapy Physics: Theory and Practice provides essential theoretical and practical knowledge for medical physicists, researchers, radiation oncologists, and radiation technologists.


"… Due to the broad range of topics covered and the clear, concise explanations, this text would be ideal for anyone wishing to study or refresh their knowledge of any central area of radiotherapy physics. IPEM Part 1 trainees in the UK (and any other trainee following a similar training programme elsewhere) in particular should take note … . Part 2 trainees will also benefit, especially in exploring the excellent source of referenced material. In comparison to other reference texts, the Handbook of Radiotherapy Physics is clear and also filled with many knowledgeable and useful observations and notes. … It is an excellent reference text and sits nicely on the shelf alongside your old copy of Williams and Thwaites."

SCOPE, December 2009

"… comprehensive reference … With contributions from renowned specialists, this book provides essential theoretical and practical knowledge to deliver safe and effective radiotherapy."

Anticancer Research, 2009, Vol. 29

"The editors have managed with great success to assemble the information submitted by the contributing authors and put it in a format that is concise, easy to read, and rich in content … it can serve as an excellent reference manual and resource."

—Niko Papanikolaou, University of Texas Health Sciences Center, Medical Physics, September 2008, Vol. 35, No. 9

Table of Contents



Structure of Matter


Interaction of Charged Particles with Matter

Interactions of Photons with Matter

The Monte Carlo Simulation of Radiation Transport

Principles and Basic Concepts in Radiation Dosimetry


Radiobiology of Tumors

Radiobiology of Normal Tissues

Dose Fractionation in Radiotherapy


Kilovoltage X-Ray Units

Linear Accelerators

Cobalt Machines


Portal Imaging Devices


Ionisation Chambers

Radiothermoluminescent Dosimeters and Diodes

Radiation Sensitive Films and Gels

Absolute Dose Determination under Reference Conditions

Relative Dose Measurements and Commissioning


From Measurements to Calculations

Kilovoltage X-Rays

Megavoltage Photon Beams

Manual Dose Calculations in Photon Beams

Electron Beams


Principles of Patient Dose Computation

Patient Dose Computation for Photon Beams

Patient Dose Computation for Electron Beams

Monte-Carlo Based Patient Dose Computation


Target Definition

Patient Data Acquisition

Magnetic Resonance (MR) Imaging in Treatment Planning

Beam Definition - Virtual Simulation

Photon-Beam Treatment Planning Techniques

Electron-Beam Treatment Planning Techniques

Dose Evaluation of Treatment Plans

Biological Evaluation of Treatment Plans


Rationale and Management of the Quality System

Quality Control of Megavoltage Equipment

Quality Assurance of the Treatment Planning Process

Quality Control of Treatment Delivery

Recording and Verification - Networking

Data Communication with DICOM


Conformal and Intensity-Modulated Radiation Therapy

Intensity-Modulation Therapy: Practical Aspects

Stereotactic Techniques

Proton Beams in Radiotherapy

Total Body Irradiation (TBI)

Total Skin Electron Irradiation

High LET Modalities


Clinical Introduction to Brachytherapy

Calibration and Quality Assurance of Brachytherapy Sources

Afterloading Equipment for Brachytherapy

Dose Calculation for Brachytherapy Sources

Brachytherapy Treatment Planning

Radiobiology of Brachytherapy


Dosimetry of Unsealed Sources

Radionuclide Selection for Unsealed Source Therapy

Radiopharmaceutical Targeting for Unsealed Source Therapy


Theoretical Background to Radiation Protection

Radiation Protection Regulation

Practical Radiation Protection in Radiotherapy

Radiation Protection Regulation in the United Kingdom


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Oncology
MEDICAL / Radiology & Nuclear Medicine
SCIENCE / Physics