Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications, 1st Edition (Hardback) book cover

Handbook of Small Animal Imaging

Preclinical Imaging, Therapy, and Applications, 1st Edition

Edited by George C. Kagadis, Nancy L. Ford, Dimitrios N. Karnabatidis, George K. Loudos

CRC Press

602 pages | 204 Color Illus.

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pub: 2016-04-12
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The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans.

Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research.

The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.


"A great overview of current small animal imaging modalities describing their principles of operation, equipment components, and most recent applications with extremely helpful illustrations. An essential book for every biologist, chemist, and physicist involved in small animal research."

—Magdalena Bazalova-Carter, PhD, Department of Physics and Astronomy, University of Victoria

"… a superb, comprehensive, and very accurate depiction of the state of the art in small animal imaging technologies and applications. This is an authoritative book and invaluable source of information for all biomedical sciences and technologies students, as well as for educators, professionals, and researchers in this multidisciplinary field."

—Professor George Kontaxakis, Universidad Politécnica de Madrid

Table of Contents


Defining Small Animal Imaging, Therapy, and Applications

Nancy L. Ford, George K. Loudos, Dimitrios N. Karnabatidis, and George C. Kagadis

Ethics and Regulations for Research with Animals

William R. Hendee

Small Animal Handling, Care, and Anesthesia

Tamara Godbey

Preclinical Models

Irene Cuadrado, Jesús Egido, Jose Luis Zamorano, and Carlos Zaragoza


Microcomputed Tomography

Nancy L. Ford

Digital Subtracted Angiography of Small Animals

Stavros Spiliopoulos, George C. Kagadis, Dimitrios N. Karnabatidis, G. Allan Johnson, and Cristian Badea

Single-Photon Emission Computed Tomography

Matthew A. Lewis

Positron Emission Tomography

Vesna Sossi and Matthew Walker


MR Imaging

Dmitri Artemov

Optical Imaging

Matthew A. Lewis


Optical-CT Imaging

Xueli Chen, Dongmei Chen, FengLin Liu, Wenxiang Cong, Ge Wang, and Jimin Liang


Mohammad Reza Ay and Nafiseh Ghazanfari

Introduction to Combining MRI with PET

Volkmar Schulz, Jakob Wehner, and Yannick Berker

Exotic Imaging Approaches

Maria Koutsoupidou and Irene S. Karanasiou


X-Ray, MRI, and Ultrasound Agents: Basic Principles

Michael F. Tweedle, Krishan Kumar, and Michael V. Knopp

Radiochemistry for Preclinical Imaging Studies

Sven Macholl and Matthias Glaser

Molecular Targets and Optical Probes

Eleni K. Efthimiadou and George Kordas


Developing Technologies for Small Animal Radiotherapy

Frank Verhaegen, James Stewart, and David Jaffray

Dosimetry of Ionizing Radiation in Small Animal Imaging

Michael G. Stabin

Treatment Planning for Small Animals

Frank Verhaegen

Radiolabeled Agents for Molecular Imaging and/or Therapy

Dimitrios Psimadas and Eirini A. Fragogeorgi


Quantification in Nuclear Preclinical Imaging

Istvan Szanda

Performance Assessment of Small Animal Imaging Systems and Common Standards

Nancy L. Ford

Monte Carlo Simulations in Imaging and Therapy

Panagiotis Papadimitroulas, George C. Kagadis, and George K. Loudos


Small Animal Imaging and Therapy: How They Affect Patient Care

Lawrence W. Dobrucki

Applications for Drug Development

Jeßica Kalra, Donald T. Yapp, Murray Webb, and Marcel B. Bally

Imaging of Intracellular Targets

Veerle Kersemans

Imaging of Cell Trafficking and Cell Tissue Homing

Veerle Kersemans

Imaging of Cardiovascular Disease

Aleksandra Kalinowska and Lawrence W. Dobrucki

Imaging Angiogenesis

Lawrence W. Dobrucki

Imaging of Hypoxia, Apoptosis, and Inflammation

Stavros Spiliopoulos and Athanasios Diamantopoulos

Vessel Wall Imaging

Stavros Spiliopoulos

About the Editors

George C. Kagadis, PhD, FAAPM, is an associate professor of medical physics and medical informatics at the University of Patras. He also holds an adjunct assistant professor appointment at the University of Texas MD Anderson Cancer Center. He is a Greek State Scholarship Foundation grantee, a Fulbright research scholar, and a fellow of the American Association of Physicists in Medicine (AAPM). He has authored about 80 journal papers and presented at more than 20 conferences. He received his PhD in medical physics from the University of Patras. His current research interests focus on medical image processing and analysis, studies in molecular imaging, IHE, and CAD applications.

Nancy L. Ford, PhD, is an assistant professor in the Department of Oral, Biological and Medical Sciences and the director of the Centre for High-Throughput Phenogenomics at the University of British Columbia. She is a full member of the AAPM and an associate editor of Medical Physics. She publishes in journals on medical physics, radiology, and dental science. She received her PhD in medical biophysics from the University of Western Ontario. Her research focuses on preclinical micro-computed tomography imaging and image-based analysis, primarily studying models of respiratory diseases, along with CBCT and MSCT for medical and dental applications.

Dimitrios N. Karnabatidis, PhD, EBIR, is an associate professor of interventional radiology at the University of Patras. He is a fellow of the Cardiovascular and Interventional Radiological Society of Europe and a member of the Hellenic Radiology Society, the Hellenic Society of Interventional Radiology, and the Western Greece Radiology Society. He has been involved as a participant/principal investigator in several national/international research projects and has published 122 articles in peer-reviewed journals. He received his PhD from the School of Medicine, University of Patras. His research interests include angiogenesis in malignant and benign diseases, the augmentation of arteriogenesis in critical limb ischemia, endothelial hyperplasia inhibition after endovascular procedures, and ureteral obstructive diseases.

George K. Loudos, PhD, is an assistant professor in the Department of Biomedical Engineering at the Technological Educational Institute of Athens. He has published 89 articles in international journals and more than 200 papers in conference proceedings. He received his PhD in biomedical engineering from the National Technical University of Athens. His research interests focus on molecular imaging using nuclear medicine techniques and medical instrumentation. He strongly supports interdisciplinary cooperation and education in the field of nanomedicine and molecular imaging.

About the Series

Imaging in Medical Diagnosis and Therapy

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Radiology & Nuclear Medicine
MEDICAL / Veterinary Medicine / Food Animal
SCIENCE / Physics