Handbook of Targeted Delivery of Imaging Agents: 1st Edition (Hardback) book cover

Handbook of Targeted Delivery of Imaging Agents

1st Edition

Edited by Vladimir P. Torchilin

CRC Press

752 pages | 6 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9780849383083
pub: 1995-08-23
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This is the first time detailed and updated information on the targeted delivery of imaging agents has been collected into a single handbook. This comprehensive volume presents the scientific background together with the latest experimental and clinical data in this fast-growing area. The Handbook of Targeted Delivery of Imaging Agents meets the requirements of the broadest audience including researchers, practitioners, and students.

The basic principles of targeted delivery of imaging are presented and discussed together with various imaging agents and different imaging modalities such as gamma-imaging, MR-imaging, and CT, PET, and SPECT imaging. The book consists of eight parts and 39 chapters covering all aspects of targeted drug delivery-from the imaging theory and chemistry of imaging agents to their experimental and clinical use for targeted visualization of cancer, including ovarian, prostate, colorectal, and thyroid cancer, cardiovascular (atherosclerosis, myocardial infarction, and thromboses) and neurological diseases, infection, and inflammation sites. A special section discusses the targeted delivery of imaging agents into lymph nodes, which are often sites of metasteses during different malignant diseases.

Monoclonal antibody-based targeted imaging agents are considered together with new approaches involving the use of labeled micelles, liposomes, and polymer-coated particles. The book describes the possible application of designer antibodies for the delivery of diagnostic agents, including the preparation, properties, labeling, and experimental use of multifunctional antibodies. The alternative improvement of antibody-directed targeting describes the application of avidin-biotin system for the delivery of imaging agents. Long circulating blood pool imaging agents are considered as a special group of organ-specific pharmaceuticals. The latest trends in the synthesis of immunoscintigraphic, MR, and CT agents are presented.

This Handbook of Targeted Delivery of Imaging Agents is a must-have reference for all those who need to stay abreast of the latest developments in this hot field.

Table of Contents

General Aspects of Targeted Imaging

Targeted Delivery of Imaging Agents: An Overview, G.L. Wolf

Targeted Gamma Imaging, H.W. Strauss

Desirable Properties of Antibodies for Imaging, I.F.C. McKenzie

Designer Antibodies as Targeted Diagnostic Units, M.K. Dewanjee and A.N. Serafini

Target-Specific Imaging Agents

Radiolabeling of Antibodies for Targeted Diagnostics, A.R. Fritzberg and D.S. Wilbur

Antibody-Associated Chelates for Targeted Imagining, Y. Arano

Chelating Polymer-Based Immunoconjugates for Targeted Diagnostic Imaging, V.P. Torchilin

Drug Targeting in Magnetic Resonance Imaging, R. Weissleder, A.A. Bogdanov, Jr., and M. Papisov

Targeted Delivery of Imaging Agents by Liposomes, W.T. Phillips and B. Goins

Targeted Imaging of Cancer

Antibody-Mediated Imaging of Ovarian Cancer, M.E. Schlegel and D.N. Krag

Ovarian Cancer Visualization with Radiolabeled Antibodies, S. Lastiria, E. Vergara, P. Varrella, W. Acampa, and M. Salvatore

Targeted Visualization of Prostate and Prostate Cancer, J.H. Texter, Jr.

Targeted Imaging of Colorectal Cancer, C.G. Gourin and D.N. Krag

99mTc-MIBI and 201Thallium Scintigraphy in the Follow-Up of Differentiated Thyroid Carcinoma, E. Klemm, A.L. Hotze, B. Vriele, and H.J. Biersack

Tumor Necrosis Imaging and Treatment of Solid Tumors, A.L. Epstein, L.A. Khawli, F.-M. Chen, M.S. Glasky, and C.R. Taylor

Potential of the Avidin-Biotin System for Diagnostic Applications, G. Paganelli, A. Samuel, P. Magnani, A. Siccardi, and F. Fazio

Avidin-Biotin System for Targeting Metastases: Basic Aspects, J.M. Jeong, T. Saga, J. Lee, and C.-S. Koh

Epithelial Membrane Antigens as a Taget for Antibody Mediated Imaging, B.R. Davidson, J. Babich, and C. Dean

Enhancement of Radiolabeled Monoclonal Antibody Uptake in Tumors with Local Hyperthermia, M.L. Hauck, M.W. Dewhirst, and M.R. Zalutsky

Targeted Visualization of Lymph Nodes

Specific Imaging Agents for Lymph Nodes, G.L. Wolf

Systemic Lymph Node Targeting with Macromolecular Imaging Agents, M.I. Papisov, R. Weissleder, and T.J. Brady

Magnetic Resonance Imaging of Lymph Nodes with Gd-Containing Liposomes, V.P. Torchilin, V.S. Trubetskoy, and G.L. Wolf

Targeted Visualization in Cardiovascular Diseases

Antimyosin Scintigraphy for the Detection of Myocyte Necrosis Associated with Various Cardiovascular Disorders, J. Narula, I. Carrió, and B.-A. Khaw

Noninvasive Imaging of Atherosclerotic Lesions: Monoclonal Antibodies and Other Approaches, B.-A. Khaw, I. Carrió, and J. Narula

Radioimmunodetection of Thrombi, F.T. Lee, A. Scott, and G.J. Bautovich

Targeting of Radiolabeled Monoclonal Antibody against Angiotensin-Converting Enzyme to the Pulmonary Vasculature, V.R. Muzykantov and S.M. Danilov

Intravascular Magnetic Resonance Imaging Contrast Media, P. Niemi

Protected Angiopolymers for Vascular Imaging, A.A. Bogdanov, Jr., R. Weissleder, and T.J. Brady

CT Diagnostic Media for Blood Pool Imaging, V.S. Trubetskoy

Targeted Imaging in Neurological Disorders

Cerebrovascular and Metabolic Imaging, A.J. Fischman, E.H. Lo, and B.R. Rosen

Neuroreceptor Imaging in Health and Disease, A.J. Fischman, J.W. Babich, and E.H. Lo

Imaging of Intracellular Signalling in the Brain, Y. Imahori, K. Matsumoto, and S. Ueda

Miscellaneous Application of Targeted Imaging Agents

History of Antibodies for Visualizing Infection and Inflammation, D.A. Rauh

Targeted Imaging of Focal Sites of Infection, J.W. Babich and A.J. Fischman

The Role of Octreotide Scintigraphy in Malignant Lymphomas, Granulomatous Diseases and Rheumatoid Arthritis, P.M. Vanhagen, P.J. van den Anker-Lugtenburg, S.W.J. Lamberts, J.C. Reuby, and E.P. Krenning

Targeted PET/SPECT Imaging

Spatial Localization of Primary and Metastic Colorectal Carcinoma Based on Fusion of CR and SPECT Monoclonal Imaging, H. Loats and A. Loats

Fluorine-18 Labeled Monoclonal Antibodies for Positron Emission Tomographic Imaging, M.R. Zalutsky, G. Vaidyanathan, P. Garg, and R.L. Page

Bromine-76 Labeled Monoclonal Antibodies for Targeted PET Imaging, A. Lövqvist, A. Sundin, and H. Lundqvist

About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pharmacology
MEDICAL / Radiology & Nuclear Medicine
SCIENCE / Chemistry / General