Handbook on Clostridia: 1st Edition (Hardback) book cover

Handbook on Clostridia

1st Edition

Edited by Peter Duerre

CRC Press

920 pages | 220 B/W Illus.

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Hardback: 9780849316180
pub: 2005-03-29
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Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical and medical applications. Despite growing scientific, medical, and industrial interest, information on basic methods, biochemical fundamentals, clinical practice, industrial applications, and novel developments remains scattered in a variety of research articles, reviews, and book chapters.

Responding to this gap in the literature, Handbook on Clostridia combines all of these topics into a single volume. The editor takes a global approach by presenting information on both Clostridia of biotechnological importance and Clostridia of medical importance. Experts in the field summarize methods, physiology, medical significance, regulation, ecosystems, genomics, and current and potential applications.

Providing a comprehensive resource on the complete field of Clostridium, this book also serves as a compilation of critical reviews on the advantages of using Clostridia for new medical and biotechnological applications. It is a valuable reference for every specialist, researcher, and student involved in this promising field.


"Considering the depth and thoroughness with which the volume was assembled, it will be quite a valuable resource for graduate students, research microbiologists, medical microbiologists, industrial biotechnologists, and toxicologists."

-Stephen Melville, Quarterly Review of Biology, Vol. 81, No. 2, 2006

Table of Contents

I. Methods

Species and strain identification methods; Jones and Keis

Quantitative proteome analysis of clostridia; Schaffer, Thormann, Hujer, and Dürre

Gene cloning in clostridia; Davis, Carter, Young, and Minton

Gene analysis of clostridia; Tummala, Tomas, and Papoutsakis

Anoxic testing and purification of enzymes; Thorsten Selmer

II. Metabolic Pathways and Transport Systems

Degradation of polymers: cellulose, xylan, pectin, starch; Leschine

Genetic organisation and regulation of hexose and pentose utilization in the clostridia; Reid

Carbohydrate uptake by the phosphotransferase system and other mechanisms; Mitchell and Tangney

Special clostridial enzymes and fermentation pathways; Buckel

Degradation of heterocyclic compounds; Andreesen

Nitrogen assimilation in the clostridia; Reid and Stutz

Nitrogen fixation; Chen

Clostridial potassium transport systems; Treuner-Lange and Dürre

Transport of phosphate; Fischer and Bahl

III. Cellular Components and Medical Aspects

Membranes lipids of clostridia; Goldfine and Johnston

Adhesins; Mastrantonio and Collignon

Clostridial toxins versus other bacterial toxins; Popoff and Stiles

Clostridial enterotoxins; McClane

Clostridial cytotoxins; Barth and Aktories

Membrane active toxins; Titball and Tweten

Clostridial neurotoxins; Johnson

Clostridial diseases of domestic animals; Songer

IV. Regulatory Mechanisms

Two-component signal transduction systems in the clostridia; Cheung, McGowan, and Rood

Comparative genomic analysis of signal transduction proteins in clostridia; Dob, Gröger, Knauber, Whitworth, and Treuner-Lange

Regulation of catabolic gene systems; Tangney and Mitchell

RNA polymerase and alternative s factors; Sonenshein, Haraldsen, and Dupuy

Transposable genetic elements of the clostridia; Lyras and Rood

V. Complex Regulatory Networks

Sporulation (morphology) of the clostridia; Labbé

Sporulation in clostridia (genetics); Dürre

Formation of solvents in clostridia; Dürre

VI. Special Groups and Ecosystems

Bacteriophages of Clostridium; Jones

Acetogenic clostridia; Drake and Küsel

Halophilic clostridia; Oren

Syntrophism among clostridiales; Plugge and Stams

Ecology and activity of clostridia in the intestine of mammals; Konstantinov, Smidt, and Akkermans

VII. Novel Developments and Applications

Industrially relevant fermentations; Ezeji, Qureshi, Cotta, and Blaschek

Metabolic engineering of solventogenic clostridia; Tomas, Tummala, and Papoutsakis

Biodegradation of hazardous materials by clostridia; Ahmad, Hughes, and Bennett

Clostridial collagenase in wound repair; Brett

Clostridia as production systems for prokaryotic and eukaryotic proteins of therapeutic value in tumor treatment; Van Mellaert, Theys, Pennington, Barbé, Nuyts, Landuyt, Lambin, Minton, and Anné

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
SCIENCE / Life Sciences / Biology / Microbiology
SCIENCE / Life Sciences / General