Heart Failure, Second Edition: 2nd Edition (Hardback) book cover

Heart Failure, Second Edition

Edited by Marc Semigran, Jordan T. Shin

© 2013 – CRC Press

500 pages | 220 B/W Illus.

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Hardback: 9781420076998
pub: 2012-12-07
eBook (VitalSource) : 9781420077018
pub: 2012-12-07
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Heart Failure, Second Edition has been updated to provide the latest advancements in heart failure research. Supplemented by more than 200 high-quality figures and illustrations, the book helps cardiologists and emergency care physicians quickly and accurately identify the cause and severity of a patient’s cardiac impairment.

New topics in this edition include:

  • Developments in mechanical and pharmacologic treatments
  • Discoveries in developmental biology
  • Up-and-coming imaging modalities
  • Surgical options for mechanical circulatory support and cardiac transplantation
  • Pharmacogenomics and gene-based and cell-based therapies
  • Gene expression/recurrence in heart failure
  • Changes in metabolic substrate utilization and pathways


" … a book for clinicians and scientists who not only seek recommendations on heart failure treatment but also look for deeper insights into the molecular mechanisms and the pathophysiology of this challenging syndrome."

European Heart Journal

Table of Contents

Part 1: Cellular and Molecular Basis for Heart Failure

A Brief Primer on the Development of the Heart

Serge Gregoire and Sean Wu

The Genetics of Dilated and Hypertrophic Cardiomyopathies

Calum Macrae

Molecular Signaling Networks Underlying Cardiac Hypertrophy and Failure

Gerald W Dorn II MD

Excitation-Contraction Coupling in the Normal and Failing Heart

Mattew Coggins, Bernhard Haring, Federica del Monte

Myocardial energetics and cellular metabolism in the failing heart

Joanne S. Ingwall

Animal Models of Heart Failure

William Carlson

Part II: Pathophysiology of Heart Failure

Ventricular Remodeling and Secondary Valvular Dysfunction in Heart Failure Progression

Kibar Yared, Judy Hung

Neurohormonal and Cytokine Activation in Heart Failure

Dennis McNamara

Cardiomyopathies in the Adult

Richard Rodeheffer

Water and Salt: the cardiorenal syndrome

Maria Rosa Costanzo

Part III: The Demographics, Diagnosis and Monitoring of Heart Failure:

The Clinical Syndrome of Heart Failure

Thomas DiSalvo, Jordon Shin

Clinical Profiles and Bedside Assessment

Lynne Warner Stevenson

Prognosis in Heart Failure

J. Susie Woo, Wayne C. Levy,

Biomarkers in Heart Failure

Ravi V. Shah, MD and Thomas J. Wang

Noninvasive Imaging Modalities for the Evaluation of Heart Failure

Kimberly A. Parks and Malissa J. Wood

Role of Invasive Monitoring in Heart Failure: Pulmonary Artery Catheters in the Post-ESCAPE Era

W. H. Wilson Tang, Gary S. Francis

Part IV: The Medical Treatment of Clinical Heart Failure

Conventional Therapy of Chronic Heart Failure: Diuretics, Vasodilators, and Digoxin

G. William Dec, MD

Conventional Therapy of Chronic Heart Failure: Beta-Adrenergic Blockers

G. William Dec

Angiotensin Receptor Blockers for Heart Failure

George V. Moukarbel

Anticoagulation in Systolic Heart Failure

Ronald Freudenberger

Role of Mineralocorticoid Antagonists in Patients with Heart Failure

Mara Giattina, Flora Sam

Treatment of Heart Failure with Preserved Ejection Fraction

Barry A. Borlaug

Cardiac Resynchronization Therapy

William T. Abraham, MD

Management of Atrial and Ventricular Arrhythmias in Heart Failure

Usha Tedrow, William G. Stevenson

Ultrafiltration for the management of volume overload

Bradley A. Bart

Heart Failure and Palliative Care

Joshua Hauser, Robert Bonow

Part V: Molecular and Biologic Therapies

Gene Therapy for Heart Failure

Stefan Janssens

About the Editors

      Marc Semigran is Associate Professor of Medicine, Harvard Medical School; Director, Heart Failure and Transplant Service, Massachusetts General Hospital; Attending Physician, Cardiac Catheterization, Laboratory, Medical Services, Coronary Care Unit, and Cardiology Consultation Service, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of fellow of several organizations, including the American College of Physicians, the American College of Cardiology, the American Heart Association, the International Society of Heart and Lung Transplantation, and the Working Group of Transplant Cardiologists.

      Dr. Semigran is a reviewer for several publications, including the American Journal of Cardiology, Anesthesia, Journal of the American College of Cardiology, New England Journal of Medicine, Journal of the American College of Cardiology, Arthritis and Rheumatism, Circulation, and the Journal of Heart and Lung Transplantation. He also contributed to the first edition of Heart Failure.

      Jordan T. Shin is Professor of Medicine, Harvard Medical School and Assistant Physician, Massachusetts General Hospital, Boston, Massachusetts, USA. He is a member of numerous organizations, including the Massachusetts Medical Society, the American Medical Association, American College of Cardiology, the American Association for the Advancement of Science, Member, the American Heart Association, and the Heart Failure Society of America.

About the Series

Fundamental and Clinical Cardiology

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Cardiology
MEDICAL / Critical Care
MEDICAL / Geriatrics