Hemostasis and Stroke presents an exciting and new understanding of current investigations and applications in stroke therapy. Although research in stroke, hematology, and related fields has made enormous progress in the last decade, stroke still remains one of the leading causes of death today. To achieve an interdisciplinary approach to current research and practice in the management of thrombosis of cerebrovascular disorders, scientists and clinicans worldwide met in Lübeck, Germany, in May 1993 for an International Symposium on Hemostasis and Stroke. This book represents the proceedings of the symposium. It also summarizes the results of recent stroke prevention trials, including critical reviews on current recommendations of acetylsalicyclic acid and the usefulness of ticlopidine. In addition, animal models of experimental cerebral ischemia are viewed under their possible application for research in embolic stroke.
Table of Contents
Preface: Toward the Pathogenesis of Thrombotic Disorders (C.M. Kessler and A. Rosengart). Thrombosis and Cerebrovascular Disease-Then, Now, and Tomorrow (L.R. Caplan). Platelet Activation in Vascular Disease (N. Murphy and D.J. Fitzgerald). Coagulation Markers in Acute Stroke (W.M. Feinberg). Coagulation Factors and Risk of Stroke (C. Gustafsson). Elevated Plasma Levels of Haemostatic Markers Indicating a Prethrombotic State in Nonrheumatic Atrial Fibrillation (R. Mitusch, M. Garbe, H.J. Siemens, T. Wagner, A. Sheikhzadeh, and K.W. Diederich). Jugular Venous Blood Hemostasis and Cerebrospinal Fluid Hemostatic Pathways in Stroke (U. Noormaa, H. Vadi, and A. Tikk). Models of Focal Brain Ischemia (J.H. Garcia and G.J. Del Zoppo). Therapeutic Approaches for Arterial Thrombosis (S.R. Hanson and L.A. Harker). Suppression of Thrombus Formation in Vitro and in Vivo by Thromboxane Synthetase Inhibition Combined with Endoperoxide/Thromboxane Receptor Antagonism (T.H. Müller, B.D. Guth, H. Weisenberger, and R. Soyka). Central Nervous System Involvement in Systemic Lupus Erythematosus and Cardiolipin Antibodies (M. Sailer, K. Wildhagen, C. Ehrenheim, H. Deicher, and J. Haas). The Influence of Leukocytes on Coagulation and Its Potential Significance in Cerebral Ischemia (A. Grau, T. Graf, and W. Hacke). The Relationship Between Early Fatality and Stress Hyperglycemia in Acute Stroke (S. Öztürk, T. Duman, and Sabahat Gürçay). Serotonin Antagonists Naftidrofuryl in the Treatment of Atherosclerotic Carotid Artery Disease (A. Rosengart, Y. Guo, A. Jahn, and C.M. Kessler). Clinical Trials of Platelet Inhibitors: Aspirin Dosis and Clinical Impact of Ticlopidine (H.C. Diener and C. Weiler). Clinical Trials with Low Dose Aspirin (B. Norrving). From European Stroke Prevention Study 1 (ESPS 1) to European Stroke Prevention Study 2 (ESPS 2) (A. Lowenthal). Dose-Dependent Effects of the Platelet Inhibitor Acetylsalicyclic Acid (A. Haass). Molecular Mechanism and Clinical Aspects of Heparin Treatment (G. Pindur, H. Kiesewetter, S. Mörsdorf, P. Scheffler, B. Wagner, H. Ruhl, and E. Wenzel). Anticoagulation in Stroke (P. Marx and S. Blum). Ischemic Cerebral Infarctions as a Sequel of Antineoplastic-Agents-Therapy (C. Klötzsch and P. Berlit). Index.