A comprehensive update to this preeminent and accessible text, this fifth edition of a bestseller was developed as a response to man's attempts to climb unaided to higher altitudes and to spend more time in these conditions for both work and recreation. It describes the ever-expanding challenges that doctors face in dealing with the changes in huma
History. The atmosphere. Geography and the human response to altitude. Genetics at high altitude. Altitude acclimatization and deterioration. Control of breathing at high altitude. Pulmonary gas exchange. Cardiovascular system. Hematology. Blood-gas transport and acid-base balance. Peripheral tissues. Exercise. Limiting factors at extreme altitude. Sleep. Nutrition, metabolism and intestinal function. Endocrine and renal systems at altitude. Central nervous system. High altitude populations. Acute mountain sickness. High altitude cerebral edema. High altitude pulmonary edema. Chronic mountain sickness and high altitude pulmonary hypertension. Other altitude-related conditions: thromboembolemic diseases, neurologic conditions, ophthalmologic conditions, altitude cough, anesthesia at altitude. The physiology and medical aspects of heat and cold. Pre-existing medical conditions at altitude. Women at altitude. Extremes of age at altitude: children and the elderly. Commercial, scientific and military activities at high altitude. Athletes and altitude. References.