Hodson and Geddes' Cystic Fibrosis provides everything the respiratory clinician, pulmonologist or health professional treating patients needs in a single manageable volume. This international and authoritative work brings together current knowledge and has become established in previous editions as a leading reference in the field. This fourth edition includes a wealth of new information, figures, useful videos, and a companion eBook.
The basic science that underlies the disease and its progression is outlined in detail and put into a clinical context. Diagnostic and clinical aspects are covered in depth, as well as promising advances such as gene therapies and other novel molecular based treatments. Patient monitoring and the importance of multidisciplinary care are also emphasized.
Throughout, the emphasis is on providing an up-to-date and balanced review of both the clinical and basic science aspects of the subject and reflecting the multidisciplinary nature of the cystic fibrosis care team.
"It is the most current CF book I have seen… This is the only CF reference text book that you need. This gives a unique balance: science translated into clinical practice."
—(Highly Commended, Internal Medicine, BMA Medical Book Awards 2016)
"The book achieves its likely intended goals well. To an average practitioner, it comes across as very accessible. I consider it a practical resource that I would add to my personal library."
—Joel Seidman, Doody's Book Review Service
"This book is the definitive CF text … This book will be invaluable to any doctor or allied health professional involved in the treatment and care of CF patients."
—Dr Jeremy Sager, Univadis/Medix
"…the book is practical and provides the reader with up-to-date information on the disease. No other textbook of this magnitude is available in the field of cystic fibrosis."
—The New England Journal of Medicine, April 2008
"This volume provides a wide range, multidisciplinary updated review on cystic fibrosis. With many helpful illustrations. For all health professionals who care for children and adolescents with cystic fibrosis."
—Pediatric Endocrinology Reviews, December 2008
INTRODUCTION: WHAT IS CYSTIC FIBROSIS?
Introduction: from the Discovery of the CFTR Gene in 1989 through to 2014; Kris De Boeck
Epidemiology of Cystic Fibrosis; Stephanie J. MacNeill
Living with Cystic Fibrosis: The Voices of Patients and Families; Matt Benn, Helen Benn, Jess Harrison, Kevin Passey, Emily Hoyle, Rupert Pearce Gould, and Frances Pearce Gould
BASIC SCIENCE FOR THE CLINICIAN
Molecular Biology of Cystic Fibrosis: CFTR Processing and Functions and Classes of Mutations; Pascale Fanen and Isabelle Sermet-Gaudelus
Underlying Concepts of the Pathophysiology of Cystic Fibrosis in the Sweat Gland, GI Tract, and Lung; Richard C. Boucher
What Have We Learned from Animal Models? Uta Griesenbach and Eric W.F.W. Alton
Interactions Between Infection and Inflammation in the Cystic Fibrosis Airway; Sanjay H. Chotirmall, Michelle A. Murray, Kevin Molloy, and Noel G. McElvaney
CFTR and Interactions with Modifier Genes and the Environment: Genotype–Phenotype Correlations and Modifier Genes; Nicholas J. Simmonds, R.J. Darrah, and M.L. Drumm
CFTR and Interactions with Modifier Genes and the Environment: Environment; Joshua N. Freedman and Michael S. Schechter
DIAGNOSTIC ASPECTS OF CYSTIC FIBROSIS
Diagnosis of the Symptomatic Patient; Colin Wallis and Nicholas J. Simmonds
Screening: What Tests? Kevin Southern
Pathway of Pain: Your "Normal" Baby Has a Life-Threatening Disease; Siân Bentley, Nicola Collins, Mary Jurd, Michele Puckey, Pat Stringer, and Andrew Bush
Microbiology of Cystic Fibrosis: Epidemiology of Cystic Fibrosis Pathogens and Clinical Microbiology Laboratory Methods; Christina Gagliardo and Lisa Saiman
New Methods for Detecting and Identifying Bacteria; Geraint B. Rogers and Gerd Döring
Infection Control; Andrew M. Jones
CLINICAL ASPECTS OF CYSTIC FIBROSIS
Respiratory Disease: Infectious Complications; J. Stuart Elborn, Ian M. Balfour-Lynn, and Diana Bilton
Pulmonary Exacerbations; Patrick A. Flume and Donald R. VanDevanter
Respiratory Disease: Noninfectious Complications; Margaret Hodson and Andrew Bush
Sleep, Lung Mechanics and Work of Breathing, Including Noninvasive Ventilation; Brigitte Fauroux and Sonia Khirani
Delivering Therapy to the Cystic Fibrosis Lung; Bruce K. Rubin and Ronald W. Williams
Upper Airway Disease; Romana Kuchai and William E. Grant
Gastrointestinal Disease in Cystic Fibrosis; Alan Steel and David Westaby
The Liver in Cystic Fibrosis; Shahid A. Khan and David Westaby
Insulin Deficiency and Cystic Fibrosis-Related Diabetes; Christopher Sheldon and Rachel Rowe
Growth and Puberty; Nicola Bridges
Bone Disease; Jennifer L. Goralski and Robert M. Aris
Other Cystic Fibrosis-Related Disease; Khin Ma Gyi and Margaret Hodson
Sexual and Reproductive Issues; J. Guy Thorpe-Beeston and Susan Madge
Transplantation; Martin Carby, Andre Simon, and Paul Aurora
Growing Old with Cystic Fibrosis; Nicholas J. Simmonds
Quality Improvement: Using Databases to Improve Cystic Fibrosis Care; Christopher H. Goss, Bradley S. Quon, and Diana Bilton
Infant and Preschool Lung Function; Sarath Ranganathan
Role of Bronchoscopy and Bronchoalveolar Lavage in Infants with Cystic Fibrosis; Claire Wainwright and Felix Ratjen
Clinical and Radiological Aspects of Imaging the Lungs; Samatha Sonnappa and Catherine M. Owens
Physiological Monitoring of Older Children and Adults; Mark Rosenthal
Exercise: Testing and Use in Therapy; Hiran Selvadurai and David Orenstein
Outcome of Clinical Trials: Electricity, Induced Sputum, and Breath; Michael Waller, Eric W.F.W. Alton, and Jane C. Davies
Chest Computed Tomography and Clinical Trials in Cystic Fibrosis; Harm A.W.M. Tiddens, Marcel van Straten, Arlette Odink, and Stephen M. Stick
Outcomes of Clinical Trials: Multiple Breath Washout Tests in Cystic Fibrosis; Padmaja Subbarao and Felix Ratjen
What Have we Learned Over the Last 5 Years? J. Stuart Elborn, Jane C. Davies, and Diana Bilton
Cystic Fibrosis Center Care; Susan Madge, Jackie Francis, and Diana Bilton
Nursing; Susan Madge and Kamilla Dack
Physiotherapy; Penny Agent, Nicola Collins, and Helen Parrott
Nutritional Aspects; Sue Wolfe and Sarah Collins
Psychology; Alistair J.A. Duff and Helen Oxley
Palliative and Spiritual Care; Finella Craig and Anna-Marie Stevens
CYSTIC FIBROSIS: THE FUTURE
Basic Science: What Will It Deliver? Gene and Stem Cell Therapy; Uta Griesenbach and Eric W.F.W. Alton
Basic Science: What Will It Deliver? Non-Gene Therapy Treatments; Jane C. Davies and Felix Ratjen
The Future: How Will Management Change? Andrew Bush and Duncan Geddes
Appendix A: History of Cystic Fibrosis; James M. Littlewood
Appendix B: How to Manage the Screened Patient; Philip Robinson