Human Developmental Toxicants: Aspects of Toxicology and Chemistry, 1st Edition (Hardback) book cover

Human Developmental Toxicants

Aspects of Toxicology and Chemistry, 1st Edition

By James L. Schardein, Orest T. Macina

CRC Press

427 pages | 295 B/W Illus.

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Description

Presenting the first database of its kind, this unique reference illustrates the relationships between the chemistry and developmental toxicity of a number of important pharmaceuticals and industrial toxicants. Human Developmental Toxicants contains up-to-date and concise information on the chemical structures, properties, and biological activities for 50 known agents that adversely affect prenatal and postnatal human development in terms of growth, viability, structure, and function.

This book presents data linking chemical and structural properties of specific toxicants as they relate to toxic effects, dosage, timing, and route of exposure. Focusing on one compound per chapter, the book also includes associated biological data from animals for each agent covered. An accompanying CD summarizes all of the data discussed in the text within an electronic database. In addition, the CD contains three-dimensional structure representations and 49 calculated physicochemical and topological parameters of the selected molecules. This information is useful for building structure activity relationship (SAR) models linking the chemical properties with observed human developmental toxicity.

As scientists continue to explore how chemicals alter human development, Human Developmental Toxicants contains the necessary information to further identify which chemical properties are responsible for adverse effects. This reference provides toxicologists, teratologists, chemists and other scientists with the latest data and information needed to perform risk assessments, predict chemicals that may produce developmental toxicity, and regulate harmful exposure.

Table of Contents

Each chapter is dedicated to a single compound and provides a general introduction followed by a description of that compound's developmental toxicology in animals and humans, a detailed analysis of its chemistry and calculated physicochemical properties, and references.

Aminopterin

Busulfan

Cyclophosphamide

Methotrexate

Chlorambucil

Mechlorethamine

Cytarabine

Tretinoin

Propranolol

Penicillamine

Vitamin A

Carbamazepine

Danazol

Paramethadione

Carbon Monoxide

Formaldehyde

Isotretinoin

Captopril

Misoprostol

Streptomycin

Methimazole

Ethylene Oxide

Tetracycline

Caffeine

Thalidomide

Primidone

Fluconazole

Ergotamine

Propylthiouracil

Medroxyprogesterone

Cocaine

Quinine

Methylene Blue

Warfarin

Phenobarbital

Trimethoprim

Methyltestosterone

Disulfiram

Valproic Acid

Carbon Disulfide

Norethindrone

Phenytoin

Etretinate

Toluene

Ethisterone

Acitretin

Valsartan

Diethylstilbestrol

Pseudoephedrine

Ethanol

Discussion and Summary

Appendix I: Physicochemical Parameter Histograms

Appendix II: Topological Parameter Histograms

Appendix III: Description of of Accompanying CD

Index

Subject Categories

BISAC Subject Codes/Headings:
MED096000
MEDICAL / Toxicology
SCI026000
SCIENCE / Environmental Science
SCI072000
SCIENCE / Life Sciences / Biology / Developmental Biology