Human Growth Hormone Pharmacology: Basic and Clinical Aspects, 1st Edition (Hardback) book cover

Human Growth Hormone Pharmacology

Basic and Clinical Aspects, 1st Edition

Edited by Kathleen T. Shiverick, Arlan L. Rosenbloom

CRC Press

192 pages

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Hardback: 9780849383847
pub: 1995-03-09
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This book addresses a wide range of basic and clinical issues in the physiology and pharmacology of growth hormone. The volume is organized like a textbook. It begins with factors contributing to GH gene expression, the functional relationships of the GH receptor, molecular biological analysis of the GH-GH receptor complex and proceeds to describe the insulin-like growth factor axis. Transgenic models are discussed for analysis of discrete effects. These discussions provide a bridge to clinically oriented discussions of growth abnormalities in GH deficient children, GH insensitivity due to deficiency of the GH receptor, and the concept of aging as a GH/IGF-I deficiency state. Discussions also include the immune system as a source and a responder to GH, GHRH, IGF-I and the effects of GH excess.

Table of Contents

Human Growth Hormone Gene Expression in Pituitary and Placenta, N.E. Cooke and S.A. Liebhaber

Growth Hormone-Prolactin Receptor Gene Family, P.A. Kelly, M. Nagano, A. Sotiropoulos, J.-J. Lebrun, P. Touraine, L. Goujon, H. Dinerstein, F. Ferrag, H. Buteau, A. Pezet, N. Esposito, J. Finidori, M.-C. Postel-Vinay, and M. Edery

Rational Design of Potent Antagonists to the Human Growth Hormone Receptor, A.M. DeVos, M.H. Ultsch, A.A. Kossiakoff, G. Fuh, B.C. Cunningham, and J.A. Wells

The Insulin-Like Growth Factor (IGF) Axis, P. Cohen and R.G. Rosenfeld

Transgenic Mice in the Study of Growth Hormone and the Insulin-Like Growth Factors, A.J. D'Ercole

Clinical Aspects of Growth Hormone Treatment of Children, A.D. Rogol

Growth Hormone Receptor Deficiency, M.A. Vaccarello

Growth Hormone, IGF-I and Human Aging, R. Marcus and A. Hoffman

Effects of Human Growth Hormone in Older Adults, A.A. Abbasi and D. Rudman

Growth Hormone Effects on the Immune System, D.A. Weigent and J. Edwin Blalock

Spontaneous & Iatrogenic Hypersomatotropism, W.H. Daughaday

Author Index

Subject Index

About the Series

Handbooks in Pharmacology and Toxicology

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Endocrinology & Metabolism
MEDICAL / Pharmacology