Hydrogels : Design, Synthesis and Application in Drug Delivery and Regenerative Medicine book cover
1st Edition

Design, Synthesis and Application in Drug Delivery and Regenerative Medicine

ISBN 9781498748612
Published February 28, 2018 by CRC Press
344 Pages 23 Color & 99 B/W Illustrations

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Book Description

Hydrogels are crosslinked, macromolecular polymeric materials arranged in a three-dimensional network, which can absorb and retain large amounts of water. Hydrogels are commonly used in clinical practice and experimental medicine for a wide range of applications, including drug delivery, tissue engineering and regenerative medicine, diagnostics, cellular immobilization, separation of biomolecules or cells, and barrier materials to regulate biological adhesions. This book elucidates the underlying concepts and emerging applications of hydrogels and will provide key case studies and critical analysis of the existing research.

Table of Contents

Microarchitecture of Water Confined in Hydrogels
Rolando Barbucci, Vincenza Spera, Emilia Armenia and Vincenzo Quagliariello

The Fate of Thixotropy in Hydrogels
Rolando Barbucci, Emilia Armenia and Vincenzo Quagliariello

Hydrogel Network Parameters
Sina Naficy and Geoffrey M. Spinks

Mechanisms of drug release from hydrogels in medical applications

B. McGeerver, G. Andrews and D. Jones

Hydrogel Coatings for Medical Device Applications
Nicola J. Irwin, Colin P. McCoy and Johann L. Trotter

Hydrogels for Bone Regeneration: An Overview
Sreekanth Pentlavalli, Helen O. McCarthy and Nicholas J. Dunne

Hydrogels in Wound Management
Enrica Caló, Lucy Ballamy and Vitaliy V. Khutoryanskiy

Hydrogels for Imaging, Sensing and Diagnostics
Dietmar Puchberger and Michael J. Vellekoop

Engineering Hyaluronan (HA) Hydrogels with Bioactive and Mechanical Signals
Helena S. Azevedo

Hydrogel Nanomaterials for Cancer Diagnosis and Therapy
Ricardo A. Pires, Yousef M. Abul-Haija, Rui L. Reis, Rein V. Ulijn and I. Pashkuleva

Thermosensitive Hydrogels for Drug Delivery and Tissue Engineering
Manisha Sharma, Long Jingjunjiao and Ali Seyfoddin

Silk Hydrogels for Drug and Cell Delivery
F. Philipp Seib

In-Situ Forming Phase-inversion Injectable Hydrogels for Controlled Drug Release
Thakur Raghu Raj Singh, Hannah L. McMillan, Ravi Sheshala, Ismaiel Abdo Tekko, Farhan Alshammari and Prashant Kesharwani

Transdermal Applications of Hydrogels
Helen L. Quinn and Ryan F. Donnelly

Preparation of Photocurable Hydrogels
Hitomi Shirahama and Bae Hoon Lee

Stimuli-Responsive Biomolecular Hydrogels for Medical Applications
Garry Laverty

Bioengineering Complexity and Tuneability in Hydrogels
Alvaro Mata, Helena Azevedo, John Connelly and Julien Gautrot

Synthetic hydrogels for 3D cell culture
Chien-Chi Lin

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Thakur Raghu Raj Singh is Lecturer in Pharmaceutics in the School of Pharmacy, Queen's University Belfast. He has obtained his PhD in Drug Delivery from School of Pharmacy, Queens University Belfast (2009), M.Sc in Pharmaceutical Sciences from University Science Malaysia (2006) and B.Pharm from Jawaharlal Nehru Technological University, India (2002). Dr Singh’s research interest is in the design and physicochemical characterisation of advanced hydrogel-based drug delivery systems for ocular, transdermal and topical applications. In particular, his current research involves fabrication and design of novel long-acting injectable and implantable hydrogel-based drug delivery systems.

Garry Laverty is Lecturer in Pharmaceutical Science and Practice at the School of Pharmacy, Queen's University Belfast. He graduated with a First Class Honours Masters degree (MPHARM) from the School of Pharmacy at Queen's University Belfast in 2005. After successful completion of his pre-registration training Garry commenced a PhD in Pharmaceutics related to the activity of peptides against the biofilm forms of medical device related pathogens.

Ryan Donnelly holds the Chair in Pharmaceutical Technology at Queen's University Belfast. His research is centred on design and physicochemical characterisation of advanced polymeric drug delivery systems for transdermal and topical drug delivery with a strong emphasis on improving therapeutic outcomes for patients. His patented bioadhesive patch design was licensed to Swedish Pharma AB, for whom Professor Donnelly now acts as a Technical Director. He is currently pursuing commercialisation of novel microneedle technologies with a number of major international pharma companies.