1st Edition

Image Processing in Radiation Therapy

ISBN 9781439830178
Published August 6, 2013 by CRC Press
286 Pages 190 B/W Illustrations

USD $180.00

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Book Description

Images from CT, MRI, PET, and other medical instrumentation have become central to the radiotherapy process in the past two decades, thus requiring medical physicists, clinicians, dosimetrists, radiation therapists, and trainees to integrate and segment these images efficiently and accurately in a clinical environment. Image Processing in Radiation Therapy presents an up-to-date, detailed treatment of techniques and algorithms for the registration, segmentation, reconstruction, and evaluation of imaging data. It describes how these tools are used in radiation planning, treatment delivery, and outcomes assessment.

The book spans deformable registration, segmentation, and image reconstruction and shows how to incorporate these practices in radiation therapy. The first section explores image processing in adaptive radiotherapy, online monitoring and tracking, dose accumulation, and accuracy assessment. The second section describes the mathematical approach to deformable registration. The book presents similarity metrics used for registration techniques, discussing their effectiveness and applicability in radiation therapy. It also evaluates parametric and nonparametric image registration techniques and their applications in radiation therapy processes. The third section assesses the efficiency, robustness, and breadth of application of image segmentation approaches, including atlas-based, level set, and registration-based techniques. The fourth section focuses on advanced imaging techniques for radiotherapy, such as 3D image reconstruction and image registration using a graphics processor unit.

With contributions from an international group of renowned authors, this book provides a comprehensive description of image segmentation and registration, in-room imaging, and advanced reconstruction techniques. Through many practical examples, it illustrates the clinical rationale and implementation of the techniques.

Table of Contents

Image Processing in Radiotherapy Applications
Image Processing in Adaptive Radiotherapy Lei Dong, Jinzhong Yang, and Yongbin Zhang
Online Monitoring, Tracking, and Dose Accumulation Geoffrey D. Hugo
Validation of Image Registration Kristy K. Brock, Michael Velec, and Jenny H.M. Lee

Similarity Metrics He Wang
Parametric Image Registration Raj Shekhar and William Plishker
Toward Realistic Biomechanical-Based Modeling for Image-Guided Radiation Adil Al-Mayah and Kristy K. Brock
Nonparametric: Demons, Diffusion, and Viscous-Fluid Approaches David Sarrut and Jef Vandemeulebroucke
Optimization in Image Registration Sanjiv S. Samant, Jian Wu, Junyi Xia, and Arun Gopal

Basic Segmentation Todd R. McNutt
Deformable Shape Models for Image Segmentation Edward L. Chaney and Stephen M. Pizer
Level Set for Radiotherapy Treatment Planning Issam El Naqa
Atlas-Based Segmentation: Concepts and Applications Eduard Schreibmann and Timothy H. Fox

Advanced Imaging Techniques
Advances in 3D Image Reconstruction Jeffrey H. Siewerdsen, J. Webster Stayman, and Frédéric Noo
Advancements in Respiratory Sorting: The Future of Respiratory Sorting Daniel A. Low
In-Room Imaging Techniques Jan-Jakob Sonke
Affine Medical Image Registration Using Graphics Processing Unit Daniel H. Adler, Sonny Chan, and J. Ross Mitchell


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Kristy K. Brock is an associate professor in the Department of Radiation Oncology at the University of Michigan, where she received her Ph.D. in nuclear engineering and radiological sciences. She is a board member of the American Association of Physicists in Medicine (AAPM), the therapy science director for the 2013 AAPM 2013 annual meeting, an editorial board member of Medical Physics, and a diplomat in therapeutic radiological physics of the American Board of Radiology. Her research focuses on deformable registration for dose accumulation and adaptive radiotherapy, the application of biomechanical modeling in correlative pathology, and therapy response assessment.


"As no dedicated course on image processing for radiation therapy typically exists, this book may very well help build the foundation for future educational initiatives in this important bridging area. One could imagine a future version of this book containing problems to allow students to exercise the knowledge they've gained."
—James Balter, PhD, University of Michigan Medical School, Ann Arbor, USA