Immunobiology of the Shark: 1st Edition (Hardback) book cover

Immunobiology of the Shark

1st Edition

Edited by Sylvia L. Smith, Robert B. Sim, Martin F. Flajnik

CRC Press

326 pages | 87 Color Illus.

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pub: 2014-12-04
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Immunity studies in sharks over the past three decades have produced some remarkable discoveries. If one message rings true, it is that alternative animal model systems, such as sharks and their relatives, have contributed very substantially to a better understanding of the development evolution of our own immune system.

Immunobiology of the Shark describes the cellular, genetic, and molecular specifics of immune systems in sharks. Diverse approaches were employed to study the immunobiology of the shark from basic microscopic observations to detailed genome annotation. The book also raises a series of fascinating questions, which can be addressed experimentally using today’s technology.

This book will be a valuable resource for mainstream immunologists, comparative immunologists, geneticists, ecologists, evolutionary biologists, and investigators engaged in shark research. The book also aims to illustrate the magnificence of these animals as model systems and underscores the importance of their study to further understand their complex, and often enigmatic, biology.


"Immunobiology of the Shark is a comprehensive resource for immunologists, evolutionary biologists and other scientists interested in understanding how the integration of cellular and humoral processes has created a highly effective survival mechanism. This volume incorporates a rich, diverse literature into a well-reasoned, comprehensive package that will permit the reader to understand topics as diverse as the placement of the shark in phylogeny, the uniqueness of its physiology and the mechanisms regulating how the rearranging immune genes make the somatic immune cell a selectable unit. An exceptional number of findings are described that are of immediate relevance to understanding immune regulation in the far more widely studied immune systems of man and mouse."

—Gary W. Litman, PhD, Distinguished University Professor, University of South Florida, Tampa, USA

"If one message rings true, it is that alternative animal model systems, such as sharks and their relatives are critical to our understanding of the scope of evolutionary change and the mechanisms underlying variation. Immunobiology of the Shark will prove to be an invaluable resource as well as guide for future investigations of how the systematic integration of pathways and processes give rise to successful biological adaptations."

—Gary W. Litman, PhD, Distinguished University Professor, University of South Florida, Tampa, USA

Table of Contents

The Diversity and Natural History of Chondrichthyan Fishes; Gregor M. Cailliet and David A. Ebert

Athena and the Evolution of Adaptive Immunity; Helen Dooley

Shark Reproduction, Immune System Development and Maturation: A Review; Lynn L. Rumfelt

Sites of Immune Cell Production in Elasmobranch Fishes: Lymphomyeloid Tissues and Organs; Carl A. Luer, Catherine J. Walsh, and A.B. Bodine

Elasmobranch Blood Cells; Ashley N. Haines and Jill E. Arnold

Leukocyte Function in Elasmobranch Species: Phagocytosis, Chemotaxis, and Cytotoxicity; Catherine J. Walsh and Carl A. Luer

Cytokines of Cartilaginous Fish; C.J. Secombes, J. Zou, and S. Bird

Shark Complement: Genes, Proteins and Function; Sylvia L. Smith and Masaru Nonaka

MHC Molecules of Cartilaginous Fishes; Simona Bartl and Masaru Nonaka

Considering V(D)J Recombination in the Shark; Ellen Hsu

Shark Immunoglobulin Light Chains; Michael F. Criscitiello

Shark T-Cell Receptors; Michael F. Criscitiello

The Shark-Family (Cartilaginous Fish) Immunogenome; Byrappa Venkatesh and Yuko Ohta

In Vitro Culture of Elasmobranch Cells; Catherine J. Walsh and Carl A. Luer

Antimicrobial Molecules of Sharks and Other Elasmobranchs: A Review; Nichole Hinds Vaughan and Sylvia L. Smith

Shark-Derived Immunomodulators; Liza Merly and Sylvia L. Smith

About the Editors

Sylvia L. Smith, PhD, SM (ASCP, AAM), professor emeritus, Florida International University, Miami, USA

Robert B. Sim, DPhil, senior research fellow, University of Oxford, and honorary professor, University of Leicester, UK

Martin F. Flajnik, PhD, professor, University of Maryland, Baltimore, USA

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Immunology
NATURE / Animals / General
SCIENCE / Life Sciences / Genetics & Genomics
SCIENCE / Life Sciences / Biology / Marine Biology