Immunological Recognition of Peptides in Medicine and Biology: 1st Edition (Hardback) book cover

Immunological Recognition of Peptides in Medicine and Biology

1st Edition

By N. D. Zegers, W.J.A. Boersma, Eric Claassen

CRC Press

320 pages

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Hardback: 9780849389672
pub: 1995-07-19
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Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.

Table of Contents

Modalities of Functional Peptide Characterization

Synthetic Peptide Libraries for Research and Drug Discovery, C. Pinilla, J.R. Appel and R. A. Houghten

Pepscan to Determine T and B Cell Epitopes, R.H. Meloen, W.C. Puijk, J.P.M. Langeveld, J.P.M. Langedijk, A. van Amerongen, and W.M.M. Schaaper

Epitope Mapping Studies with Paper Disc-Bound Peptides, W. van 't Hof, M. van den Berg, and R.C. Aalberse

Construction and Utilization of Peptide Libraries Displayed by Filamentous Bacteriophage, G. Cesareni, L. Castagnoli, L. Dente, G. Iannolo, C. Vetriani, F. Felici, A. Luzzago, P. Monaci, A. Nicosia, and R. Cortese

The Analysis of Peptide Binding to MHC and of MHC Specificity, S. Buus, L. Ø. Pedersen, and A. Stryhn

Promiscuity and Specificity of T Cell Epitopes, F. Sinigaglia, P. Panina-Bordignon, P. Valsasnini, and J. Hammer

Processing of Proteins in the MHC Class II Pathway, J.M. van Noort

Use of T Cell Epitopes in Raising Immune Responses, N. D. Zegers and W.J.A. Boersma

Structure Function and Synthesis of Special, Derivatized Peptides

Progress and Frontiers in Prediction of B and T Cell Epitopes, S. Modrow and H. Wolf

Analysis of Peptide and Protein Structure, H.J. Dyson

Synthesis, Analysis, and Conformation of Glycopeptides and Phosphopeptides, L. Otvos, Jr., G.I. Szendrei, L. Gorbics, and L. Urge

Lipopeptides as Adjuvants and Integrated Adjuvanticity, G. Jung and W.G. Bessler

Immunological Recognition of Peptides

Optimization of Specific Anti-Peptide Responses: Immunization and Adjuvant, W.J.A. Boersma and Eric Claassen

Epitope Specific Detection of Antibodies, E. Claassen and W.J.A. Boersma

Multiple Antigen Peptides for Immunization, N.D. Zegers, E. Claassen, and W.J.A. Boersma

Effects of Conformation, Amino Acid Sequence, and Carrier Coupling on the Immunological Recognition of Peptide and Protein Antigens, R. Jemmerson

The Potency of Peptides in Immune Responses and in Immune Response Analysis: Single Amino Acid Specificity, N.D. Zegers, E. Claassen, and W.J.A. Boersma

Preclinical and Experimental Clinical Applications of Peptides

Peptide Vaccines, R. Arnon and M. Sela

Cytotoxic Epitope-Based Peptide Vaccines, W.M. Kast, R.M.P. Brandt, and C.J.M. Melief

Peptide Applications in Autoimmune Disease Research, K. Gerritse

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Immunology