1st Edition

Immunological Recognition of Peptides in Medicine and Biology

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ISBN 9780849389672
Published July 19, 1995 by CRC Press
320 Pages

USD $385.00

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Book Description

Immunological Recognition of Peptides in Medicine and Biology gives a state-of-the-art overview on the use of peptides and peptide-ligand interactions, and the critical role they play in recognition patterns for the regulation of various biological functions. A wide range of applications are discussed, including some experimental preclinical ones such as epitope mapping, peptide libraries, and production of amino acid-specific antibodies and their therapeutic use in oncology and infectious disease vaccines. Each chapter also includes step-by-step protocols to aid in actual experiments. Several alternative techniques and strategies are discussed by different authors offering the reader an opportunity to select the most favorable application for a specific biological problem.

Table of Contents

Modalities of Functional Peptide Characterization
Synthetic Peptide Libraries for Research and Drug Discovery, C. Pinilla, J.R. Appel and R. A. Houghten
Pepscan to Determine T and B Cell Epitopes, R.H. Meloen, W.C. Puijk, J.P.M. Langeveld, J.P.M. Langedijk, A. van Amerongen, and W.M.M. Schaaper
Epitope Mapping Studies with Paper Disc-Bound Peptides, W. van 't Hof, M. van den Berg, and R.C. Aalberse
Construction and Utilization of Peptide Libraries Displayed by Filamentous Bacteriophage, G. Cesareni, L. Castagnoli, L. Dente, G. Iannolo, C. Vetriani, F. Felici, A. Luzzago, P. Monaci, A. Nicosia, and R. Cortese
The Analysis of Peptide Binding to MHC and of MHC Specificity, S. Buus, L. Ø. Pedersen, and A. Stryhn
Promiscuity and Specificity of T Cell Epitopes, F. Sinigaglia, P. Panina-Bordignon, P. Valsasnini, and J. Hammer
Processing of Proteins in the MHC Class II Pathway, J.M. van Noort
Use of T Cell Epitopes in Raising Immune Responses, N. D. Zegers and W.J.A. Boersma
Structure Function and Synthesis of Special, Derivatized Peptides
Progress and Frontiers in Prediction of B and T Cell Epitopes, S. Modrow and H. Wolf
Analysis of Peptide and Protein Structure, H.J. Dyson
Synthesis, Analysis, and Conformation of Glycopeptides and Phosphopeptides, L. Otvos, Jr., G.I. Szendrei, L. Gorbics, and L. Urge
Lipopeptides as Adjuvants and Integrated Adjuvanticity, G. Jung and W.G. Bessler
Immunological Recognition of Peptides
Optimization of Specific Anti-Peptide Responses: Immunization and Adjuvant, W.J.A. Boersma and Eric Claassen
Epitope Specific Detection of Antibodies, E. Claassen and W.J.A. Boersma
Multiple Antigen Peptides for Immunization, N.D. Zegers, E. Claassen, and W.J.A. Boersma
Effects of Conformation, Amino Acid Sequence, and Carrier Coupling on the Immunological Recognition of Peptide and Protein Antigens, R. Jemmerson
The Potency of Peptides in Immune Responses and in Immune Response Analysis: Single Amino Acid Specificity, N.D. Zegers, E. Claassen, and W.J.A. Boersma
Preclinical and Experimental Clinical Applications of Peptides
Peptide Vaccines, R. Arnon and M. Sela
Cytotoxic Epitope-Based Peptide Vaccines, W.M. Kast, R.M.P. Brandt, and C.J.M. Melief
Peptide Applications in Autoimmune Disease Research, K. Gerritse

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