First Published in 1990, this text brings together the work of several investigators who used in vitro techniques to probe the nature of embryonic cell response to a diverse group of chemical agents. It focuses on the approaches, limitations, usefulness and applicability of defining mechanisms underlying altered development. This work includes discussions on pharmacodynamic principles and placental transfer mechanisms. It also examines the potential for in vitro systems to serve as an adjunct to the risk assessment process. Ideal for both the layman and the expert in this area, this volume provides a general understanding of the types of approaches that can be used and specific approaches in investigating altered development.
Introduction. In Vitro Evaluations of Human Placental Functions and Toxic Responses. Pharmacokinetic Aspects of In Vitro Teratogenicity Studies: Comparison to In Vivo. Application of Cell-Cell Communication Assays to Problems of Developmental Toxicology. Cell Migration and Contractility. Analysis of Cell Proliferation in Developing Orofacial Tissue. Membrane Lipid Metabolism and Development of the Palate. In Vitro Assays of Cell Adhesion: Application to Teratogenicity Testing. In Vitro Approaches to the Study of Embryonic Cell Death in Developmental Toxicity. The Regulation of Genes Encoding Extracellular Matrix Proteins: In Vitro Studies and Relationships to Teratogenic Mechanisms. In Vitro Assays in Developmental Toxicology: Their Potential Application in Risk Assessment.
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