This book covers all major areas of interest in the rapidly expanding field of in vitro methods for percutaneous absorption studies. Specific areas discussed include diffusion cell design, receptor fluid, preparation of skin, and temperature. The book covers experimental methodology, as well as the underlying principles and fundamentals that help professionals and students gain an understanding of the basis for currently used methodology.
Preparation of Human and Animal Skin (R. Bronaugh and S. Collier). Diffusion Cell Design (C. Gummer and H. Maibach). A Flow-Through Diffusion Cell (R. Bronaugh). Individual and Regional Variation with In Vitro Percutaneous Absorption (R. Wester and H. Maibach). Receptor Fluids (S. Collier and R. Bronaugh). Assessment of Vehicle Factors Influencing Percutaneous Absorption (J. Zatz). Cutaneous Metabolism (S. Collier, J. Storm and R. Bronaugh). Effect of Occlusion (D. Bucks, R. Guy and H. Maibach). Skin Storage Conditions (W. Reifenrath and B. Kemppainen). In Vitro Absorption Through Damaged Skin (R. Scott). Localization of Drugs in the Skin (A. Rolland). Expression of Absorption Data (S. Collier and R. Bronaugh). The LPP Theory of Skin Penetration Enhancement (B. Barry). In Vitro Percutaneous Absorption of Alachlor and Atrazine (R. Wester, D. Bucks and H. Maibach). In Vivo-In Vitro Correlations for Hydrophobic Compounds (R. Bronaugh and S. Collier). In Vitro Absorption-Skin Flap Model (J. Riviere). Percutaneous Penetration from Soil: Inhibition or Enhancement? (D. Bucks, R. Wester, and H. Maibach). Short-Term In Vitro Skin Exposure (R. Wester and H. Maibach). Protocol for In Vitro Percutaneous Absorption Studies (R. Bronaugh and S. Collier). Finite Dose In Vitro Percutaneous Permeation Based on the Diffusion Model: Estimation of Pharmacokinetic Parameters and Prediction of the Pharmacokinetics Profiles (K. Kubota and H. Maibach). Effect of Sodium Lauryl Sulfate-Induced Skin Irritation on In Vitro Percutaneous Absorption (Klaus-P. Wilhelm, Christian Surber, and Howard I. Maibach). Percutaneous Absorption in Irritant Dermatitis (K. Wilhelm, C. Surber, and H. Maibach).