The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta (β) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor-β3 sums up editor Ugo Ripamonti’s research into the osteogenic activity of the three mammalian TGF-β isoforms, particularly in primates. It explores how the mammalian TGF-β isoforms have the potential to shed light on the apparent redundancy of bone induction signaling.
The book unearths the profound and important bone inductive activity of the TGF-β3 isoform. It includes accounts of extensive research in non-human primates from craniofacial tissue regeneration, heterotopic tissue induction, and chapters on periodontal tissue regeneration and synergistic induction of bone formation. It also discusses the future clinical role of the TGF-β isoform, including in human studies.
This book contributes to the fascinating history of BMP and TGF-β research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.
Table of Contents
Introduction: The Discovery of Redundancy and the Bone Induction Prerogative of the Three Mammalian Transforming Growth Factor-β Isoforms. Regenerative Medicine, the Induction of Bone Formation, Bone Tissue Engineering, and the Osteogenic Proteins of the Transforming Growth Factor-β Supergene Family. Rapid Induction of Bone Formation by the Transforming Growth Factor-β3 Isoform. Induction of Bone Formation by the Mammalian Transforming Growth Factor-βs: Molecular and Morphological Insights. Regeneration of Mandibular Defects in Nonhuman Primates by the Transforming Growth Factor-β3 and Translational Research in Clinical Contexts. Synergistic Induction of Bone Formation by Relatively Low Doses of Transforming Growth Factor-β1 and -β3 in Binary Application with Recombinant Human Osteogenic Protein-1. Induction of Periodontal Tissue Regeneration by Recombinant Human Transforming Growth Factor-β3 with and without Myoblastic/Pericytic Stem Cells in Papio ursinus.
Ugo Ripamonti is a leader in the field of tissue induction and differentiation in postnatal osteogenesis. His principal achievement is the demonstration of the induction of bone formation in non-human primate models. In 1994 he was appointed professor at the Medical School University of the Witwatersrand in South Africa, leading its newly founded Bone Research Laboratory. He has written more than 200 publications, given more than 120 invited lectures at international symposia, and organized a series of workshops and symposia at the World Biomaterials Congresses and the International Conferences on Bone Morphogenetic Proteins.