Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine: 4th Edition (Hardback) book cover

Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine

4th Edition

Edited by Burke A. Cunha, Cheston B. Cunha

CRC Press

472 pages | 20 Color Illus. | 53 B/W Illus.

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Hardback: 9781138297067
pub: 2020-06-10
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Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E hasbeen fully updated and revised. The clinical diagnostic approach to common infectious disease problems in the CCU is the underlying theme in the book. Emphasized throughout is the importance of formulating an accurate early presumptive clinical syndromic diagnosis which is the basis for selecting optimal initial antimicrobial therapy in the CCU. Without an accurate presumptive clinical diagnosis, effective therapy is unlikely at best. Based on the most probable clinical diagnosis, optimal antibiotic empiric therapy, based on antimicrobial stewardship principles, minimizes resistance and antibiotic complications in the CCU.

This new edition features chapters that explain the tenets of differential diagnostic reasoning, differential diagnostic characteristics of fever patterns in the CCU. The proper interpretation of rapid diagnostic tests, in the appropriate clinical context, is included. The diagnostic importance of cardinal clinical findings, particularly when combined, in the appropriate clinical context is emphasized and remains the basis for clinical problem solving in the CCU. Uniquely, critical diagnostic physical findings in the CCU, including color atlas of diagnostic eye findings, are included as important diagnostic determinants in the CCU.

Written by infectious disease clinicians for CCU consultants, Infectious Diseases and Antimicrobial Stewardship in Critical Care Medicine 4E remains a useful evidence based and experience tempered key clinical resource for infectious disease problems in the CCU.

Key Features

  • Essentials of the tenets of clinical diagnostic reasoning is explained as it relates to formulating a rapid and accurate clinical syndromic diagnosis in the CCU

  • The diagnostic significance of fever patterns and their relationship to the pulse rate in the proper

clinical context is explained in depth as related to the CCU setting

  • Formulating an accurate early clinical syndromic diagnosis is presented as essential since it is the

basis of effective empiric antibiotic therapy in the CCU

  • How to combine key non-specific laboratory and imaging findings to increase diagnostic specificity and diagnostic probability in the CCU is presented

  • Clinical perspective on the proper interpretation of the clinical significance of rapid diagnostic test results in the CCU is included

  • A clinical approach to apparent "antibiotic failure" in the CCU is presented either due to actual antibiotic failure or seeming but unrelated non-antibiotic failure

  • Section focuses on the practical aspects of antimicrobial stewardship particularly as related to optimizing dosing effectiveness while minimizing resistance and adverse effects in the CCU

Table of Contents

Clinical Diagnostic Approach in the Critical Care Unit

Chapter 1 Diagnostic Reasoning and Clinical Problem Solving

Burke A. Cunha

Chapter 2 Clinical Approach to Fever in the Critical Care Unit

Burke A. Cunha

Chapter 3 Physical Exam Clues and Their Mimics in Infectious Diseases in Critical Care

Yehia Y. Mishriki

Chapter 4 Ophthalmologic Clues to Infectious Diseases and Their Mimics in Critical Care

Cheston B. Cunha, Michael J. Wilkinson and David A. Quillen

Chapter 5 Radiology of Infectious Diseases and Their Mimics in Critical Care

Jocelyn A. Luongo, Boris Shapiro, Orlando A. Ortiz, and Douglas S. Katz

Chapter 6 Non-Specific Laboratory Tests in the CCU

Charles W. Stratton.

Chapter 7 Infections in Returning Travelers in the in the CCU and its Mimics

Elise Kochoumian, Jonathon Moore, Bushra Mina, Kevin Cahill

Chapter 8 Diagnostic Approach to Rash and Fever in the CCU

Lee S. Engel, Charles V. Sanders, Fred A. Lopez


Chapter 9 Severe Tick-borne Infections and its Mimics in the CCU

Praveen Sudhindra, Gary P Wormser

Clinical Syndromic Approach in the Critical Care Unit

Chapter 10 The clinical approach to sepsis and its mimics in the critical care unit

Abdullah Chahin, and Steven M. Opal

Chapter 11 Acute Bacterial Meningitis and Its Mimics in CCU

Burke A. Cunha

Chapter 12 Encephalitis and its Mimics in the CCU

John J Halperin

Chapter 13 Severe Community Acquired Pneumonia in the CCU

Burke A. Cunha

Chapter 14 Legionnaire’s Disease and Severe Pneumonia Mimics in the CCU

Burke A. Cunha

Chapter 15 Severe Influenza pneumonia and its mimics in the CCU

Eleni E. Magira

Chapter 16 Severe Non-Influenza Viral Pneumonia in the Critical Care Unit

David Waldner, Thomas J Marrie and Wendy Sligl

Chapter 17 Nosocomial Pneumonia in the CCU

Burke A. Cunha



Chapter 18 Central Venous Catheter (CVC) Infection in the CCU

Emilio Bouza and Almudena Burillo

Chapter 19 Acute Infective Endocarditis and Its Mimics in the CCU.

John L Brusch

Chapter 20 Diagnostic Approach to Myocarditis in the Coronary Care Unit

Shabnam Seydafkan and Jason M. Lazar

Chapter 21 Intra-Abdominal Surgical Infections and Their Mimics in the CCU

Donald E. Fry

Chapter 22 Clostridium difficile and its Mimics in the CCU

Burke A. Cunha

Chapter 23 Diagnostic Approach to Fulminant Hepatitis in the CCU

Huei-Wen Lim and David Bernstein

Chapter 24 Diagnostic Approach To Acute Kidney Injury In The Critical Care Unit

Sonali Gupta, Divyansh Bajaj, Sana Idrees and Joseph Mattana

Clinical Approach to Infections in Compromised Hosts in the Critical Care Unit

Chapter 25 Overwhelming Post-Splenectomy Infections

Larry I. Lutwick and Jana Preis

Chapter 26 Infections in Cirrhosis in the CCU

John M. Horne and Laurel C. Preheim

Chapter 27 Febrile neutropenia in the CCU

Perrine Parize, Anne Pouvaret, Paul-Louis Woerther, Frédéric Pène, and Olivier Lortholary

Chapter 28 Infections Related To Steroids And Immunosuppressive Agents In The Critical Care Unit

Gülden YILMAZ and Müge AYHAN

Chapter 29 Infections in Solid Organ Transplant Recipients Admitted to the Critical Care Unit

Almudena Burillo, Patricia Muñoz and Emilio Bouza

Chapter 30 Care of Critically Ill Patients with HIV

Joseph Metmowlee Garland, Andrew Levinson and Edward Wing


Antimicrobial Therapy and Antibiotic Stewardship in the Critical Care Unit

Chapter 31 Principles of Antibiotic Stewardship in the CCU

Cheston B. Cunha

Chapter 32 Colonization, Infection and Resistance in the Intensive Care Unit (ICU)

Edward Septimus



Chapter 33 Rapid Infectious Diseases Diagnostics in the Intensive Care Unit (ICU)

Bronwen Garner and Kimberly Hanson

Chapter 34 Antibiotic Therapy of Multidrug Resistant (MDR) Organisms in the CCU

Burke A. Cunha

Chapter 35 Antibiotic Therapy in the Penicillin Allergic Patient in the CCU

Burke A. Cunha

Chapter 36 Adverse Reactions to Antibiotics in Critical Care

Diane M. Parente, Cheston B. Cunha and Michael Lorenzo

Chapter 37 Antibiotic Dosage Adjustment in Renal Insufficiency and Hemodialysis in the CCU

Damary C. Torres, Kristina Bruno and Danielle Maffei

Chapter 38 Antibiotic Failure: Apparent or Actual in the CCU

Burke A. Cunha

About the Editors

Cheston B. Cunha, MD, FACP is Medical Director of the Antimicrobial Stewardship Program at Rhode Island Hospital and The Miriam Hospital in Providence, Rhode Island, USA. He is also an attending in adult infectious disease in the Division of Infectious Diseases is Assistant Professor of Medicine at Brown University Alpert School of Medicine. Dr. Cunha has written/co-written 51 articles, 53 book chapters and 7 books. He has been an Editor of Antibiotic Stewardship, Antibiotic Essentials (15th, 16th Edition), Clinical Infectious Diseases (3rd Edition), and Infectious Diseases in Critical Care Medicine and Antibiotic Stewardship (4th Edition). He has been an annual recipient of the Dean’s Excellence in Teaching Award from the Alpert Medical School of Brown University.

Burke A. Cunha, MD, MACP is Chief, Infectious Disease Division at NYU Winthrop Hospital, Mineola, New York and Professor of Medicine, State University of New York School of Medicine, Stony Brook, New York. He is one of the world’s leading authorities on antimicrobial therapy and clinical infectious diseases. He has written/edited 1355 articles, 221 book chapters, and 36 books. He has received numerous teaching awards, including the Aesculapius Award for teaching excellence and the Spatz Award for clinical excellence. Dr. Cunha is a Master of the American College of Physicians, awarded for lifetime achievement as a Master Clinician and Master Teacher.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Infectious Diseases
MEDICAL / Emergency Medicine
MEDICAL / Internal Medicine