Infectious Diseases in Immunocompromised Hosts: 1st Edition (Hardback) book cover

Infectious Diseases in Immunocompromised Hosts

1st Edition

By Vassil St. Georgiev

CRC Press

1,232 pages

Purchasing Options:$ = USD
Hardback: 9780849385537
pub: 1997-12-29
SAVE ~$52.50
Currently out of stock
$350.00
$297.50
x

FREE Standard Shipping!

Description

Because of limited access to medical libraries and medical journals, the majority of clinicians may find it difficult to keep informed on the latest developments in drug manufacture and treatment of infectious diseases in immunocompromised patients. This new handbook strives to fulfill the need for information in this area of medicine.

This is the first book on drug development and treatment of infectious diseases in immunocompromised hosts. It integrates both results from large-scale clinical trials and single cases as well as small groups of patients. It covers bacterial, viral, parasitic, and fungal infections, including a wide array of diseases. Infectious Diseases in Immunocompromised Hosts encompasses not only opportunistic infections associated exclusively with immunocompromised patients, but also common infections that become life-threatening for immunosuppressed individuals.

Table of Contents

SECTION I. VIRAL INFECTIONS

Herpesviridae

Cytomegalovirus

Clinical Manifestations of HCMV Disease

Immunologic Response to HCMV Disease

HCMV Infection in Immunocompromised Hosts and AIDS

Studies on Therapeutics

Evolution of Therapies and Treatment of HCMV Infections

References

Varicella-Zoster Virus

Studies on Therapeutics

Evolution of Therapies and Treatment of Varicella-Zoster Infections

References

Herpes Simplex Virus

Host Immune Response to Herpes Simplex Virus Infections

Evolution of Therapies and Treatment of Herpes Simplex Virus Infections

References

Epstein-Barr Virus

Immune Response to Epstein-Barr Infection

Evolution of Therapies and Treatment of Epstein-Barr Infections

References

Human Herpesvirus-6, Human Herpesvirus-7, and Human Herpesvirus-8

Role of Herpesvirus-6 in HIV Disease

Drug Susceptibility of Human Herpesvirus-6

Human Herpesvirus-7

Human Herpesvirus-8

References

Papovaviridae

Human Papillomavirus

Studies on Therapeutics

Evolution of Therapies and Treatment of Papillomavirus Infections

References

Polyomaviruses

Progressive Multifocal Leukoencephalopathy (JC Virus Infection)

References

Adenoviridae

Adenoviruses

Adenovirus Modulation of Immune Responses

Treatment of Adenovirus Infections

References

Parvoviridae

Human Parvovirus B19

Evolution of Therapies and Treatment of Human Parvovirus B19 Infections

References

Paramyxoviridae

Respiratory Syncytial Virus

Respiratory Syncytial Virus Infections in Immunocompromised Patients

Evolution of Therapies and Treatment of Respiratory Syncytial Virus Infections

References

Poxviridae

Molluscum Contagiosum

Treatment of Moluscum Contagiosum

References

Hepadnaviridae

Hepatitis

Hepatitis A

Hepatitis B

Hepatitis C

Hepatitis D (Delta)

References

SECTION II. BACTERIAL INFECTIONS

Actinomycetes

Nocardia spp.

Evolution of Therapies and Treatment of Nocardiosis

Biological Response Modifiers from Nocardia spp.

References

Rhodococcus equi

Evolution of Therapies and Treatment of Rhodococcus equi Infection

References

Tsukamurella paurometabolum

Evolution of Therapies and Treatment of T. paurometabolum Infection

References

Mycobacterium tuberculosis

Mycobacterium tuberculosis Infections in AIDS Patients

Host Immune Defense Against Mycobacterium tuberculosis

Studies on Therapeutics

Evolution of Therapies and Treatment of Mycobacterium tuberculosis Infections

References

Mycobacterium bovis

Host Immune Response to Mycobacterium bovis Infection

Treatment of Mycobacterium bovis Infections

References

Nontuberculous Mycobacterial Infections

In Vitro and In Vivo Activities of Anti-Nontuberculous Mycobacterial Agents

Virulence Antigens of Nontuberculous Mycobacteria

Nontuberculous Mycobacterial Infections and AIDS

Mycobacterium avium Complex (MAC)

Mycobacterium scrofulaceum

Mycobacterium kansasii

Mycobacterium fortuitum-chelonae Complex

Mycobacterium xenopi

Mycobacterium haemophilum

Mycobacterium szulgai

Mycobacterium malmoense

Mycobacterium genavense

Mycobacterium simiae

Mycobacterium marinum

Mycobacterium gordonae

Mycobacterium ulcerans

Mycobacterium terrae-triviale Complex

Mycobacterium asiaticum

Mycobacterium thermoresistibile

Mycobacterium neoaurum

Mycobacterium nonchromogenes

Mycobacterium flavescens

Mycobacterium paratuberculosis

Mycobacterium shimoidei

Mycobacterium celatum

Phylogeny of Fast-Growing Mycobacteria

References

Enterobacteriaceae

Shigella spp.

Studies on Therapeutics

Evolution of Therapies and Treatment of Shigellosis

References

Salmonella spp.

Evolution of Therapies and Treatment of Salmonella Infections

Salmonella typhimurium

Salmonella arizonae

Salmonella dublin

Salmonella choleraesius

Salmonella enteritidis

References

Yersinia enterocolitica

Host Immune Defense Against Yersinia enterocolitica

Evolution of Therapies and Treatment of Y. enterocolitica Infections

References

Campilobacter spp.

Studies on Therapeutics

Macrolide Antibiotics

Fluoroquinol-4-ones

Mechanism of Fluoroquinolone Resistance

Evolution of Therapies and Treatment of Campylobacteriosis

Campylobacter jejuni/coli-Associated Enteritis

Campilobacter fetus-Associated Infections

Campilobacter Infections in HIV-Positive and AIDS Patients

Helicobacter pylori-Induced Infections in HIV-Positive Patients

Host Immune Response to Campylobacteriosis

Campylobacter jejuni Bacteremia and the Guillain-Barré Syndrome

References

Non-Cholera Vibrio spp.

Treatment of Vibrio vulnificus Infections

References

Listeria Monocytogenes

Host Immune Defense Against Listeriosis

Listeriosis in AIDS Patients

Treatment of Listeriosis

References

Gastrointestinal Infections in the Immunocompromised Host

Therapeutic Strategies for Enteric Infections

Prevention of Enteric Infections

References

Neisseriaceae

Acinetobacter spp.

Evolution of Therapies and Treatment of Acinetobacter Infections

References

Moraxella spp.

Evolution of Therapies and Treatment of M. nonliquefaciens Infection

References

Neisseria spp.

Treatment of Neisseria Infections

References

Pseudomonadaceae

Burkholderia (Pseudomonas) cepacia

Treatment of B. cepacia Infections

Drug Resistance of Pseudomonas spp.

References

Stenotrophomonas (Xanthomonas) maltophilia

Drug Development and Treatment of S. maltophilia Infections

References

Rickettsiaceae

Bartonella spp.

Evolution of Therapies and Treatment of Bartonella Infections

References

Ehrlichia spp.

Evolution of Therapies and Treatment of Ehrlichiosis

References

Alcaligenaceae and Related Bacteria

Alcaligenes xylosoxidans

Evolution of Therapies and Treatment of Alcaligenes xylosoxidans

Ochrabactrim anthropi

Introduction and Taxonomy

Treatment of Ochrabactrim anthropi Infection

Agrobacterium radiobacter

"Achromobacter" Group B

References

Leuconostoc spp.

Treatment of Leuconostoc spp. Infections and the Problem of Resistance to Vancomycin

References

Treponema pallidum

Host Immune Response to Treponema pallidum

Central Nervous System Involvement in Syphilis

Evolution of Therapies and Treatment of Syphilis

Syphilis in HIV-Infected Patients

Antibiotic Treatment of Neurosyphilis in Immunocompromised Hosts

Biopharmacology of Penicillin Chemotherapy of Syphilis

The Jarsch-Herxheimer Reaction

References

Mycoplasma spp.

Mycoplasma pneumoniae

Mycoplasma genitalium

Studies on Therapeutics

Fluoroquinolones

Macrolide Antibiotics

Role of Hormones in Genital Mycoplasms

Evolution of Therapies and Treatment of Mycoplasma Infections

Mycoplasma pneumoniae Infections

Mycoplasma hominis Infections

Mycoplasma fermentans (incognitus strain) Infections

Mycoplasma penetrans Infections

Mycoplasmas as Cofactors Promoting AIDS

In Vitro Susceptibility of Mycoplasma spp. to Antimicrobial Agents and Clinical Significance

References

SECTION III. PARASITIC INFECTIONS

References

Eucoccidiida

Cryptosporidium spp.

Evolution of Therapies and Treatment of Cryptosporidiosis

References

Isospora spp.

Evolution of Therapies and Treatment of Isosporiasis

References

Toxoplasma gondii

Host Immune Response to Toxoplasma gondii

Studies on Therapeutics

Mode of Action and Pharmacokinetics of Sulfonamides and Antifolate Drugs

Evolution of Therapies and Treatment of Toxoplasmosis

The Role of Immunotherapy in the Treatment of Toxoplasmosis

Drug-Resistant Mutants of Toxoplasma gondii

References

Microsporidia

Ocular Microsporidiosis

Host Immune Response to Microsporidia

Studies on Therapeutics

Fumagillin

Albendazole

Benomyl

Microsporidial Targets for Chemotherapeutic Intervention

Evolution of Therapies and Treatment of Microsporidiosis

References

Leishmania spp.

Visceral Leishmaniasis (Kala-azar)

Cutaneous Leishmaniasis

Mucocutaneous Leishmaniasis

Diffuse Cutaneous Leishmaniasis

Evolution of Therapies and Treatment of Leishmaniasis

Liposomal Amphotericin B

Host Immune Response to Leishmaniasis

References

Strongyloides stercoralis

Strongyloidiasis in HIV-Infected Patients

Cutaneous Manifestations of Strongyloidiasis

Corticosteroid Therapy as a Predisposing Factor for Strongyloidiasis

Treatment of Strongyloidiasis

References

Cyclospora spp.

Host Immune Response to Cyclospora

Treatment of Cyclosporiasis

References

Arthropod Infestations in HIV-Infected Patients

Scabies (Sarcoptidosis)

Demodicidosis

References

SECTION IV. FUNGAL INFECTIONS

General Characteristics of Fungi

Fungal Taxonomy

Fungal Cell Envelope and Mode of Action of Antimycotic Agents

Fungal Cell Wall

Fungal Cell Membrane

Mechanism of Action of Polyene Antibiotics

Inhibition of Glucan Biosynthesis

Cell Wall Mannoproteins as Potential Target of Antifungal Agents

Chitin Biosynthesis as Target of Antifungal Agents

Sterol Biosynthesis as Target of Antifungal Agents

Inhibition of Fungal Squalene Epoxidase

Inhibition of Fungal Cytochrome P-450-Dependent 14a-Sterol Demethylase

Inhibition of Fungal D14-Reductase and D8-D7-Isomerase

The Role of Iron in Fungal Metabolism

Removal of Iron from Erythrocytes

Secretion of Chelators

Citrate or Transferin-Mediated Uptake

Plasma Membrane Ferric Reductases

Molecular Approaches to Novel Targets for Antifungal Therapy

Cryptococcal Diphenol Oxidase

MyristoylCoA:Protein N-Myristoyltransferase

Candida albicans PHR1 Gene and Its Role in Cell Wall Growth

Macrophage-Induced Genes of Histoplasma capsulatum

Deuteromycota (Fungi Imperfecti)

References

Cryptococcus neoformans

Studies on Therapeutics

Amphotericin B

5-Fluorocytosine

Azole Derivatives

Antibiotics Other than Amphotericin B

Miscellaneous Antifungal Agents

Host Immune Response to Cryptococcal Infection

Interleukin-12

The Role of Antibodies in Protection Against C. neoformans Infection

Evolution of Therapies and Treatment of Cryptococcosis

Amphotericin B

Combination of Amphotericin B with 5-Fluorocytosine and Other Drugs

5-Fluorocytosine

Azole Derivatives

Cryptococcus neoformans var. gattii

Cryptococcus albidus

Cryptococcus laurentii

References

Candida spp.

Human Candidiasis

Candidal Infections in the Immunocompromised Host

Pathogenicity of Candida spp.

Host Immune Defense Against Candida albicans

Reconstitution of Defective Cell-Mediated Immunity

Studies on Therapeutics

Amphotericin B

Fluconazole

Clotrimazole

Compound D0870

Compound SCH 39304

Sertaconazole

Lanoconazole

Allylamine Derivatives

a-(1H-Imidazol-1-yl)arylmethyl)pyrrole

Anticandidal Lipopeptides

Nykkomycins

Drug Resistance of Candida spp.

Evolution of Therapies and Treatment of Candidiasis

Cutaneous Candidiasis

Chronic Mucocutaneous Candidiasis

Oral and Esophageal Candidiasis

Systemic Candidiasis

Candidal Onychomycosis

Candidal Paronychia

Candidal Onychomycosis

Treatment of Candidal Onychomycosis and Paronychia

Emerging Candida spp. Infections

Candida zeylanoides

Candida famata

Candida kefir

Candida glabrata

Candida lusitaniae

Candida krusei

Candida rugosa

Candida guilliermondii

Candida norvegensis

Candida lipolytica

Candida viswanathii

Candida haemulonii

Pichia jadinii (Candida utilis)

References

Malassezia (Pytirosporum) spp.

Evolution of Therapies and Treatment of Malassezia Infections

Fungemia and Systemic Disease

Folliculitis

Tinea (Pityriasis) Versicolor

Seborrheic Dermatitis

References

Trichosporon beigelii

Evolution of Therapies and Treatment of Trichosporonosis

Blastoschizomyces capitatus

References

Rhodotorula spp.

Evolution of Therapies and Treatment of Rhodotorula Infections

Antibiotic YM-47522

References

Other Yeast-Like Fungi

Hansenula spp.

Evolution of Therapies and Treatment of Hansenula Infections

References

Fungi of the Order Moniliales

Dematiaceae Fungi: Phaeohyphomycosis and Chromoblastomycosis

Phaeohyphomycosis

Chromoblastomycosis

References

Geotrichum candidum

Evolution of Therapies and Treatment od Geotrichosis

References

Histoplasma spp.

Studies on Therapeutics

Evolution of Therapies and Treatment of Histoplasmosis

Host Immune Defense Against Histoplasmosis

African Histoplasmosis

Management of African Histoplasmosis and Evolution of Therapies

References

Blastomyces dermatitidis

Role of Host Immune Response Against Blastomyces dermatitidis

Studies on Therapeutics

Evoluation of Therapies and Treatment of Blastomycosis

References

Aspergillus spp.

Host Immune Response to Aspergillosis

Studies on Therapeutics

Evolution of Therapies and Treatment of Aspergillosis

Aspergillus chevalieri

References

Coccidioides immitis

Studies on Therapeutics

Evolution of Therapies and Treatment of Coccidioidomycosis

Host Immune Response Against Coccidioidomycosis

References

Paracoccidioides brasiliensis

Host Immune Response to Paracoccidioidomycosis

Paracoccidioidomycosis in the Immunocompromised Host

Evolution of Therapies and Treatment of Paracoccidioidomycosis

References

Hyalohyphomycosis

Evolution of Therapies and Treatment of Hyalohyphomycosis

References

Penicillium marneffei

Evolution of Therapies and Treatment of Penicilliosis marneffei

References

Paecilomyces spp.

Evolution of Therapies and Treatment of Paecilomyces Infections

References

Zygomycota

Zygomycosis (Mucormycosis, Phycomycosis)

Zygomycetous Infections

Evolutions of Therapies and Treatment of Zygomycosis

References

Pneumocystis carinii

Pneumocystis carinii Pneumonia

Studies on Therapeutics

Evolution of Therapies and Treatment of Pneumocystis carinii Pneumonia

References

Index

About the Series

Handbooks in Pharmacology and Toxicology

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MED022090
MEDICAL / Infectious Diseases
MED044000
MEDICAL / Immunology