Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention, 1st Edition (Hardback) book cover

Inflammation, Oxidative Stress, and Cancer

Dietary Approaches for Cancer Prevention, 1st Edition

Edited by Ah-Ng Tony Kong

CRC Press

640 pages | 52 B/W Illus.

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Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.

Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics.

The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

Table of Contents

Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer

Overview on Oxidative Stress, Inflammation, Cancer Initiation/Progression, and How to Prevent Carcinogenesis/Cancer

Jong Hun Lee and Ah-Ng Tony Kong

Overview of Obesity, Inflammation, and Cancer

Ximena Paredes-Gonzalez, Tin Oo Khor, Limin Shu, Constance Lay-Lay Saw, and Ah-Ng Tony Kong

Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention

Chung S. Yang, Xiaoxin Chen, and Guang-Yu Yang

Overview of Common Dietary Phytochemicals Possessing Antioxidant Properties through Nrf2

Limin Shu, Chengyue Zhang, and Ah-Ng Tony Kong

Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals

Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals

Ann M. Bode and Zigang Dong

Biomarkers for Diet in Cancer Prevention Studies

Zheng-Yuan Su, Limin Shu, and Ah-Ng Tony Kong

Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals

Metabolism and Transport of Anticancer and Anti-Inflammatory Phytochemicals across the Gastrointestinal Tract

Yong Ma and Ming Hu

Pharmacokinetics of Dietary Isothiocyanates and Flavonoids

Yoshihiko Ito, Shizuo Yamada, and Marilyn E. Morris

Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective

Retinoic Acid Signaling in Hematopoiesis and Immune Functions, and Options for Chemoprevention

Rodica P. Bunaciu and Andrew Yen

Vitamin D and Inflammation in Cancer: Emerging Concepts

Katrina M. Simmons, Wei-Lin W. Wang, Martin P. R. Tenniswood, and JoEllen Welsh

Vitamin E Family of Compounds and Cancer Prevention

Kimberly Kline, Weiping Yu, Richa Tiwary, and Bob G. Sanders

The Protective Role of Vitamin E in Inflammation and Cancer

Amanda K. Smolarek and Nanjoo Suh

Vitamin D and Cancer: Research Update and Clinical Recommendations

Kathleen M. Wesa and Barrie R. Cassileth

Section V: Omega-3 and Omega-6 Fatty Acids

Plant and Marine Sources of Omega-3 Polyunsaturated Fatty Acids, Inflammation, and Cancer Prevention

Julie K. Mason, Ashleigh K. A. Wiggins, and Lilian U. Thompson

Polyunsaturated Fatty Acids and Cancer Prevention

Janel Suburu and Yong Q. Chen

Anti-Inflammatory and Proresolving Effects of Docosahexaenoic Acid: Implications for Its Chemopreventive Potential

Young-Joon Surh, Na-Young Song, Ha-Na Lee, and Hye-Kyung Na

Section VI: Flavonoids and Polyphenols

Green Tea and Cancer Prevention

Naghma Khan and Hasan Mukhtar

Curcumin from Turmeric Spice, Anti-Inflammatory and Antioxidant Phytochemical, and Cancer Prevention

Tin Oo Khor and Ah-Ng Tony Kong

Flavonoids: Impact on Prostate Cancer and Breast Cancer

James Cardelli, David Coleman, and Katherine D. Crew

Cancer Prevention by Isoflavone

Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar

Anti-Inflammatory Efficacy of Silibinin: Role in Cancer Chemoprevention

Alpna Tyagi, Gagan Deep, and Rajesh Agarwal

Cancer Prevention by Antioxidant Compounds from Berries

Noah P. Zimmerman, Dan Peiffer, and Gary D. Stoner

Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates

Garlic and Cancer Prevention

Chi Chen

Molecular Mechanisms of Cancer Chemoprevention with Benzyl Isothiocyanate

Anuradha Sehrawat and Shivendra V. Singh

Suppression of Prostate Carcinogenesis by Dietary Isothiocyanates

Young-Sam Keum

Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention

Cancer Prevention with Selenium: Costly Lessons and Difficult but Bright Future Prospects

Junxuan Lü, Cheng Jiang, and Jinhui Zhang

Chemoprevention of Lung Cancer by Ginseng

Michael S. You, Lucina C. Rouggly, Ming Hu, Zhen Yang, Ming You, and Yian Wang

Anti-Inflammatory Botanical Dietary Supplements for Women’s Health: Role in Breast Cancer Prevention?

Birgit M. Dietz and Judy L. Bolton

PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues

Wing Lam, Scott Bussom, Zaoli Jiang, Wei Zhang, Fulan Guan, Shwu- Huey Liu, and Yung-Chi Cheng

Lipoic Acid in the Prevention and Treatment of Inflammatory Disease and Cancer

Kate Petersen Shay, Regis F. Moreau, and Tory M. Hagen

Section IX: Epigenetics and Chronic Inflammation

Epigenetic Modifications by Dietary Phytochemicals in Cancer Prevention

Tabitha M. Hardy and Trygve O. Tollefsbol

Nutritional Phytochemicals and the Management of Chronic Inflammation

Laura Marler and John M. Pezzuto

About the Editor

Ah-Ng "Tony" Kong, Ph.D., is a distinguished professor (PII), Glaxo Endowed Chair Professor of Pharmaceutics, and director of the Graduate Program in Pharmaceutical Sciences at Rutgers, the State University of New Jersey. He is also the director for the Center for Pharmacogenetics and Pharmacogenomics at Rutgers University. Dr. Kong has published more than 200 original research papers, review articles, and book chapters. He has chaired and given presentations in many national and international symposia and conferences and is currently serving on the board of 15 international journals. His research areas are in dietary phytochemicals (signaling and gene expression, nutrigenomics, cancer chemoprevention); animal tumor models of the prostate, colon, and skin; epigenetics/epigenomics; oxidative/redox/inflammatory stress response; Nrf2-mediated nuclear transactivation and signaling; and pharmacokinetics and pharmacodynamics of phytochemicals.

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nutrition
MEDICAL / Oncology