1st Edition

Inflammation, Oxidative Stress, and Cancer Dietary Approaches for Cancer Prevention

Edited By Ah-Ng Tony Kong Copyright 2014
    640 Pages 52 B/W Illustrations
    by CRC Press

    640 Pages 52 B/W Illustrations
    by CRC Press

    Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals.

    Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics.

    The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

    Section I: Inflammation, Oxidative Stress, Nutritional Phytochemicals, and Cancer

    Overview on Oxidative Stress, Inflammation, Cancer Initiation/Progression, and How to Prevent Carcinogenesis/Cancer
    Jong Hun Lee and Ah-Ng Tony Kong

    Overview of Obesity, Inflammation, and Cancer
    Ximena Paredes-Gonzalez, Tin Oo Khor, Limin Shu, Constance Lay-Lay Saw, and Ah-Ng Tony Kong

    Inflammation-Induced Esophageal and Colon Adenocarcinoma Formation in Animal Models: Mechanisms of Carcinogenesis and Prevention
    Chung S. Yang, Xiaoxin Chen, and Guang-Yu Yang

    Overview of Common Dietary Phytochemicals Possessing Antioxidant Properties through Nrf2
    Limin Shu, Chengyue Zhang, and Ah-Ng Tony Kong

    Section II: Signal Transduction, Molecular Targets, and Biomarkers of Dietary Cancer-Preventive Phytochemicals

    Signal Transduction and Molecular Targets of Dietary Cancer-Preventive Phytochemicals
    Ann M. Bode and Zigang Dong

    Biomarkers for Diet in Cancer Prevention Studies
    Zheng-Yuan Su, Limin Shu, and Ah-Ng Tony Kong

    Section III: In Vivo Absorption and Pharmacokinetics of Nutritional Phytochemicals

    Metabolism and Transport of Anticancer and Anti-Inflammatory Phytochemicals across the Gastrointestinal Tract
    Yong Ma and Ming Hu

    Pharmacokinetics of Dietary Isothiocyanates and Flavonoids
    Yoshihiko Ito, Shizuo Yamada, and Marilyn E. Morris

    Section IV: Vitamins A, D, and E Cancer Prevention, and Clinical Perspective

    Retinoic Acid Signaling in Hematopoiesis and Immune Functions, and Options for Chemoprevention
    Rodica P. Bunaciu and Andrew Yen

    Vitamin D and Inflammation in Cancer: Emerging Concepts
    Katrina M. Simmons, Wei-Lin W. Wang, Martin P. R. Tenniswood, and JoEllen Welsh

    Vitamin E Family of Compounds and Cancer Prevention
    Kimberly Kline, Weiping Yu, Richa Tiwary, and Bob G. Sanders

    The Protective Role of Vitamin E in Inflammation and Cancer
    Amanda K. Smolarek and Nanjoo Suh

    Vitamin D and Cancer: Research Update and Clinical Recommendations
    Kathleen M. Wesa and Barrie R. Cassileth

    Section V: Omega-3 and Omega-6 Fatty Acids

    Plant and Marine Sources of Omega-3 Polyunsaturated Fatty Acids, Inflammation, and Cancer Prevention
    Julie K. Mason, Ashleigh K. A. Wiggins, and Lilian U. Thompson

    Polyunsaturated Fatty Acids and Cancer Prevention
    Janel Suburu and Yong Q. Chen

    Anti-Inflammatory and Proresolving Effects of Docosahexaenoic Acid: Implications for Its Chemopreventive Potential
    Young-Joon Surh, Na-Young Song, Ha-Na Lee, and Hye-Kyung Na

    Section VI: Flavonoids and Polyphenols

    Green Tea and Cancer Prevention
    Naghma Khan and Hasan Mukhtar

    Curcumin from Turmeric Spice, Anti-Inflammatory and Antioxidant Phytochemical, and Cancer Prevention
    Tin Oo Khor and Ah-Ng Tony Kong

    Flavonoids: Impact on Prostate Cancer and Breast Cancer
    James Cardelli, David Coleman, and Katherine D. Crew

    Cancer Prevention by Isoflavone
    Yiwei Li, Dejuan Kong, Aamir Ahmad, Bin Bao, and Fazlul H. Sarkar

    Anti-Inflammatory Efficacy of Silibinin: Role in Cancer Chemoprevention
    Alpna Tyagi, Gagan Deep, and Rajesh Agarwal

    Cancer Prevention by Antioxidant Compounds from Berries
    Noah P. Zimmerman, Dan Peiffer, and Gary D. Stoner

    Section VII: Garlic Organosulfur Compounds and Crucifer Glucusinolates

    Garlic and Cancer Prevention
    Chi Chen

    Molecular Mechanisms of Cancer Chemoprevention with Benzyl Isothiocyanate
    Anuradha Sehrawat and Shivendra V. Singh

    Suppression of Prostate Carcinogenesis by Dietary Isothiocyanates
    Young-Sam Keum

    Section VIII: Selenium, Herbal Medicines, Alpha Lipoic Acid, and Cancer Prevention

    Cancer Prevention with Selenium: Costly Lessons and Difficult but Bright Future Prospects
    Junxuan Lü, Cheng Jiang, and Jinhui Zhang

    Chemoprevention of Lung Cancer by Ginseng
    Michael S. You, Lucina C. Rouggly, Ming Hu, Zhen Yang, Ming You, and Yian Wang

    Anti-Inflammatory Botanical Dietary Supplements for Women’s Health: Role in Breast Cancer Prevention?
    Birgit M. Dietz and Judy L. Bolton

    PHY906, a Cancer Adjuvant Therapy, Differentially Affects Inflammation of Different Tissues
    Wing Lam, Scott Bussom, Zaoli Jiang, Wei Zhang, Fulan Guan, Shwu- Huey Liu, and Yung-Chi Cheng

    Lipoic Acid in the Prevention and Treatment of Inflammatory Disease and Cancer
    Kate Petersen Shay, Regis F. Moreau, and Tory M. Hagen

    Section IX: Epigenetics and Chronic Inflammation

    Epigenetic Modifications by Dietary Phytochemicals in Cancer Prevention
    Tabitha M. Hardy and Trygve O. Tollefsbol

    Nutritional Phytochemicals and the Management of Chronic Inflammation
    Laura Marler and John M. Pezzuto


    Ah-Ng "Tony" Kong, Ph.D., is a distinguished professor (PII), Glaxo Endowed Chair Professor of Pharmaceutics, and director of the Graduate Program in Pharmaceutical Sciences at Rutgers, the State University of New Jersey. He is also the director for the Center for Pharmacogenetics and Pharmacogenomics at Rutgers University. Dr. Kong has published more than 200 original research papers, review articles, and book chapters. He has chaired and given presentations in many national and international symposia and conferences and is currently serving on the board of 15 international journals. His research areas are in dietary phytochemicals (signaling and gene expression, nutrigenomics, cancer chemoprevention); animal tumor models of the prostate, colon, and skin; epigenetics/epigenomics; oxidative/redox/inflammatory stress response; Nrf2-mediated nuclear transactivation and signaling; and pharmacokinetics and pharmacodynamics of phytochemicals.