Extensively updated to reflect the outpouring of research in the field, this Second Edition documents the theory and practical utilization of aerosols in inhalation therapy and tracks advances in aerosol formulation, development, and application. Supplying readers with studies on physiology, metabolism, and pharmacokinetics for a clear understanding of the therapeutic impact of lung aerosols, this guide analyzes inhalation technologies for a vast array of diseases including asthma, cystic fibrosis, COPD, pulmonary infectious diseases, and diabetes.
Table of Contents
AERODYNAMIC BEHAVIOR. Deposition Mechanics of Pharmaceutical Particles in Human Airways. Thermodynamics of Inhaled Hygroscopic Drugs. Use of Mathematical Aerosol Deposition Models in Predicting the Distribution of Inhaled Therapeutic Aerosols.
BIOLOGICAL CONSIDERATIONS. Physiology and Pharmacology of the Airways.
Solute Transport Following Aerosol Deposition in the Lungs. Drug Metabolism and Enzyme Kinetics in the Lung. Bioavailability and Pharmacokinetics if Inhaled Drugs. Therapeutic Uses of Lung Aerosols. PHARMACEUTICS AND PHARMACEUTICAL TECHNOLOGY.
Atomization and Nebulizers. Ultrasonic and Electrohydrodynamic Methods for Aerosol Generation. Spray-Drying and Supercritical Fluid Particle Generation Techniques. Interfacial Phenomena and Phase Behavior in Metered Dose Inhaler Formulations. Molecular Scale Behavior in Alternative Propellant Based Inhaler Systems. Aerosol Generation from Propellant-Driven Metered Dose Inhalers. Medical Devices for the Delivery of Therapeutics Aerosols to the Lungs. Next Generation Dry Powder Inhalation Delivery Systems